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Research Results and Publications

Applications

申請單號	申請人	Project title
B10401	Chen, Sih-Ta	Using nomic technology, LC-MS/MS spectrometry, and other technical platforms to develop multiple clinical markers for predicting progression of chronic kidney disease
B10402	Chung, Wen-Hung	Human whole genome disease research
B10403	Chen, Jinn-Shiun	Development of non-invasive microRNAs tests as tools for early detection of colorectal cancer
B10404	Alice Yu	Taiwan biosignature for breast cancer
B10501	Alice Yu	Taiwan biosignature for breast cancer
B10502	Lu, Jang-Jih	Application of screening of colorectal cancer associated mutation genes by next generation sequencer
B10503	Wu-Chou, Yah-Huei	Genetic architecture of IRF6-related oral clefts
B10601	Huang, Shih-Chiang	The significance of HOXA cluster inactivation in aggressiveness of meningeal solitary fibrous tumors/hemaniopericytoma
B10602	Hsu, Peng-Wei	Comprehensive and the largest genetic validation and clinical study of human glioblastomas and lower-grade gliomas
B10701	Hsu, Peng-Wei	Comprehensive and the largest genetic validation and clinical study of human glioblastomas and lower-grade gliomas
B10801	Hsu, Peng-Wei	Comprehensive and the largest genetic validation and clinical study of human glioblastomas and lower-grade gliomas
B10802	Hsieh, Sen-Yung	Decipher genomic and epigenomic alternations in the liver and digestive cancers
B10901	Yu, Ming-Chin	To study role of vault RNA 2-1 (vtRNA 2-1) in prognosis and carcinogenesis of patients with hepatocellular carcinoma
B10902	Tian, Ya-Chung	Polyomavirus BK and JC genome integrating into human genome in human cancers
B11001	Lin, Tung-Yi	Search for protein biomarkers of breast cancer by proteomics.
B11002	Liao, Chun-Ta	Artificial intelligence analysis for whole transcriptome sequencing plus circulating tumor cells for oral cavity patient with extra-nodal extension: A prospective study for predicting recurrence, distant metastasis and survival
B11003	Kang, Chung-Jan	Artificial intelligence analysis for whole transcriptome sequencing plus circulating tumor cells for oral cavity patient with extra-nodal extension: A prospective study for predicting recurrence, distant metastasis and survival
B11004	Hsu, Peng-Wei	A comprehensive study to discover exosomal biomarker signatures for glioblastoma to prioritize patient care via using a highly sensitive magneto-electrochemical sensing platform
B11005	Kuo, Wen-Ling	Glycosylation of PKM2 controls metabolic adaptation and progression of breast cancer
B11006	Hsu, Peng-Wei	A comprehensive study to discover exosomal biomarker signatures for glioblastoma to prioritize patient care via using a highly sensitive magneto-electrochemical sensing platform
B11007	Huang, Wen-Kuan	Microsatellite instability analysis and tumor immune microenvironment correlation analysis
B11008	Hsu, Peng-Wei	A comprehensive study to discover exosomal biomarker signatures for glioblastoma to prioritize patient care via using a highly sensitive magneto-electrochemical sensing platform
B11009	Hsieh, Chia-Hsun	Mechanisms of metabolic dysfunction in metastatic cancer-induced cachexia
B11010	Hsu, Hung-Chih	Investigation of the correlation between Immune cell type of tumor microenvironment, T cell receptor and treatment response/prognosis in metastatic colorectal cancer
B11101	Tsai, Ming-Han	A retrospective seroepidemiological study of pertussis among older adults in Northern Taiwan
B11102	Liao, Chun-Ta	Artificial intelligence analysis for whole transcriptome sequencing plus circulating tumor cells for oral cavity patient with extra-nodal extension: A prospective study for predicting recurrence, distant metastasis and survival
B11103	Lin, Tung-Yi	Search for protein biomarkers of breast cancer by proteomics
B11104	Kuo, Chang-Fu	Application of next generation sequencing for the development of precision medicine in Taiwan
B11105	Kang, Chung-Jan	Investigation of molecular mechanism of CTGF in regulating oral cavity squamous cell carcinoma with perineural invasion (PNI) and clinical diagnosis and treatment applications
B11201	Kang, Chung-Jan	Investigation of molecular mechanism of CTGF in regulating oral cavity squamous cell carcinoma with perineural invasion (PNI) and clinical diagnosis and treatment applications
B11301	Lin, Bo-Ting	Exploring the immune status and recurrence factors in hepatocellular carcinoma patients after curative
B11302	Rajendra	Comparative analysis of antibody profiles of pediatric and adult COVID-19 patients in the Omicron era
B11303	Lai, Ming-Wei	Investigating extracellular vesicles and their role in hepatitis B virus-related liver disease progression
B11304	Hsieh, Cheng-En	Investigation of antitumor immune response in patients with unresectable hepatocellular carcinoma undergoing proton radiotherapy combined with atezolizumab and bevacizumab
B11305	Yeh, Chau-Ting	Genetic and virological factors in the cirrhotic liver in association with hepatocellular carcinoma postoperative prognosis

Applications from National Biobank Consortium of Taiwan

Application No. (NBCT No.)	Principal Investigator	Affiliation & Department	Title of the Project
NB2020001 (NBCT No.200016)	Gigin Lin	Radiology, Chang Gung Medical Foundation	Precision medicine for human gastric and colon cancers: Integrated metabolomics and morphomics imaging analysis
NB2022001 (NBCT No.220079)	Huang, Yen Chun	Operation management, Marker Exploration Corp.	Clinical Utility of Plasma Cancer Proteomic Profile for Early Detecting Multiple Primary Cancer
NB2022002 (NBCT No.220080)	Chi-Cheng Huang	Comprehensive Breast Health Center, Taipei Veterans General Hospital	New drug development guided from biomedical big data
NB2022003 (NBCT No.220095)	Wayne Hsieh	Medical Solution Cluster, Roche Product Ltd.	Research and application of oncology clinico-genomic big database
NB2022004 (NBCT No.220089)	Yi-Hsin Yang	National Institute of Cancer Research, National Health Research Institutes	Data governance for cancer-specific data in National Biobank Consortium in Taiwan
NB2022005 (NBCT No.220098)	Tian-Lu Cheng	Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University	Precising the pro-antibody engineering by computer simulation, X-ray crystallography and cryogenic electron microscopy to comprehensively improve the disease selectivity and reduce the side effects of antibody drugs
NB2023001 (NBCT No. 230110)	Ren-Hua Chung	Institute of Population Health Sciences, National Health Research Institutes	Multi-omics analysis to identify novel immune genes for triple-negative breast cancer and functionally validating their roles in cancer subtyping, tumorigenesis and immune microenvironment
NB2023002 (NBCT No. 230113)	Shiu-Wen Huang	Department of Research and development, Taipei Medical University Hospital	Application of novel natural naphthoquinone-based derivatives as anti-angiogenic, anti-lymphogenic and anti-tumor agents and its underlying mechanisms
NB2023003 (NBCT No. 230115)	Tang-Yuan Chu	Department of Obstetric & Gynecology, Tzu Chi Hospital, Hualien	FE25 cell transformation as a serum bioassay to detect cancers and estimate tumor load: a validation study and characterization of the transformation activity
NB2023004 (NBCT No.230126)	Kun-Yu Lai	Department of Optics and Photonics, National Central University	High throughput Raman spectroscopy: A new DNA testing for cancers and cord blood
NB2024001 (NBCT No.230125)	Huamei Chang	Research & Development, SP BioMED Co. Ltd.	Polygenic risk score for early onset breast cancer of Taiwan
NB2024002 (NBCT No.240140)	Yu-Shan Wang	General Manager Office, UniPharma Co. Ltd.	Analysis of the differential expression of the DR-70 tumor marker in various cancer patients compared to a healthy population, utilizing serum samples from the National Biobank Consortium of Taiwan
NB2024003 (NBCT No.240136)	Ming-Fang Wu	Department of Internal Medicine, Chung Shan Medical University Hospital	Using comprehensive cancer genetic testing and national biobank consortium of Taiwan database information to explore the genetic variation expression, clinical manifestations and treatment results of Taiwan's six advanced cancer patients
NB2024004 (NBCT No.240144)	Kun-Ming Rau	Department of Hematology-Oncology, E-Da Cancer Hospital	Predictive value of next generation sequence for therapeutic effect on anti-cancer therapy
NB2024005 (NBCT No.240152)	Nai-Jung Chiang	Department of Oncology, Taipei Veterans General Hospital	Exploring the association between cancer genomic alterations, clinical manifestations and treatment outcomes

Publications

1. Su SC, Lin CW, Liu YF, Fan WL, Chen MK, Yu CP, Yang WE, Su CW, Chuang CY, Li WH, Chung WH, and Yang SF. Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities. Theranostics 2017; 7(5):1088-99.

2. Chang PY, Chen CC, Chang YS, Tsai WS, You JF, Lin GP, Chen TW, Chen JS*, Chan EC*. MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection. Oncotarget. 2016 Mar 1;7(9):10663-75.

3. Chang PY, Chen JS, Chang NC, Chang SC, Wang MC, Tsai SH, Wen YH, Tsai WS, Chan EC*, Lu JJ*. NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing. Oncotarget. 2016 Jun 21;7(25):37566-37580.

4. Wu-Chou YH, Lu YC, Chen KP, Chang HF, Lin YT, Lo LJ. Association Studies Between Regulatory Regions of IRF6/TP63 Genes and Nonsyndromic Oral Clefts. Cleft Palate Craniofac J. 2019 Jul;56(6):778-785. Epub 2018 Nov 12.

5. Wei KC, Chen CY, Feng LY, Huang WT, Chen CH, Hsu PW, Wang K, Hood LE, Chen LY. The rs16906252: C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort. PLoS One. 2017 Jun 2;12(6):e0178842. eCollection 2017.

6. Yu MC, Lee CW, Lin CH, Wu CH, Lee YS, Tsai CL, Tsai CN. Differential hypermethylation of the VTRNA2-1 promoter in hepatocellular carcinoma as a prognostic factor: Tumor marker prognostic study. Int J Surg. 2020 Jul; 79:282-289. Epub 2020 May 14.

7. Fan WL, Yang LY, Hsieh JC, Lin TC, Lu MJ, Liao CT*. Prognostic Genetic Biomarkers Based on Oncogenic Signaling Pathways for Outcome Prediction in Patients with Oral Cavity Squamous Cell Carcinoma. Cancers (Basel). 2021 May 30;13(11):2709.

8. Wu MJ, Chen CJ, Lin TY, Liu YY, Tseng LL, Cheng ML, Chuu CP, Tsai HK, Kuo WL, Kung HJ, Wang WC. Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics. 2021 Jun 26;11(16):7779-7796. eCollection 2021.

9. Liao CT, Yang LY, Lee LY, Lin CY, Wang HM, Ng SH, Yen TC, Fan WL*, Hsieh JC*. Whole-exome sequencing identifies biosignatures that predict adverse survival outcomes in surgically treated patients with oral cavity squamous cell carcinoma. Oral Oncol. 2021 Nov;122:105547. Epub 2021 Oct 23.

10.SLC11A1 predicts the overall survival of patients with colorectal cancer. Hsu HC, Lee YS, Imbang TI, Liu TC, Hung SI. Am J Cancer Res. 2024 Jun 15;14(6):2839-2851. eCollection 2024.

(update: 01/16/2025)