Center for Mitochondrial Research and Medicine

                                                                                                           LANGUAGE:CHINESE

About US

Director: Professor Tsu-Kung Lin

Our Goals: The purpose of the Center for Mitochondrial Research and Medicine is to actively develop molecular diagnosis and transplantation therapy for mitochondrial-related diseases, so as to achieve precise and personalized medicine for the treatment of mitochondrial-related neuromuscular degeneration, abnormal immune metabolism, cancer, and cardiovascular diseases.

Members

Director: Professor Tsu-Kung Lin

Deputy Director: Professor Feng-Sheng Wang

First group: Molecular Diagnosis and Therapeutics Platforms for Mitochondrial Disease

Members: Chia-Wei Liou、Kuo-Chung Lan、Tsu-Kung Lin、Feng-Sheng Wang、Tzu-Jou Wang、Jong-Jer Lee、Wei-Shiung Lian、Kai-Lieh Lin

Second group: Interplay of Mitochondria and Innate Immunity in Human Diseases

Members: Pei-Wen Wang、Feng-Chih Shen、Yu-Jih Su、Jiin-Haur Chuang、Hui-Ching Chuang、Yen-Hsiang Chang

PhD Scientists: Yu-Han Lin、Yin-Hua Cheng

News

Latest News

Seminars

Publication List

2020年

1. Hung-Yu Lin, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Wei-Shiung Lian, Ching-Hua Hsieh, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Chia-Shiang Chang, Ching-Yi Lin, Yu-Jih Su, Pei-Wen Wang 2020 Jul 10;33(2):66-86. doi: 10.1089/ars.2019.7737. Epub 2020 Feb 18. Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue. Antioxid Redox Signal.
2. Yen-Hsiang Chang, Hung-Yu Lin, Feng-Chih Shen, Yu-Jih Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Ching-Yi Lin, Shao-Wen Weng, Pei-Wen Wang 2020 Jul 29;11:445. doi: 10.3389/fendo.2020.00445. eCollection 2020. The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes. Front Endocrinol (Lausanne).
3. Feng-Chih Shen, Ben-Chung Cheng, Jung-Fu Chen 2020 Jul-Aug;14(4):345-349. doi: 10.1016/j.orcp.2020.06.006. Epub 2020 Jul 9. Peri-renal fat thickness is positively associated with the urine albumin excretion rate in patients with type 2 diabetes. Obes Res Clin Pract.
4. Hung-Yu Lin, Jiin-Haur Chuang, Pei-Wen Wang, Tsu-Kung Lin, Min-Tsui Wu, Wen-Ming Hsu, Hui-Ching Chuang 2020 Aug 19;9(9):1920. doi: 10.3390/cells9091920. 5-aza-2'-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma Cells.
5. Meng-Han Tsai, Chung-Wen Kuo, Tsu-Kung Lin, Chen-Jui Ho, Pei-Wen Wang, Jiin-Haur Chuang, Chia-Wei Liou 2020 Aug 11;9(8):1885. doi: 10.3390/cells9081885. Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population. Cells.
6. Feng-Sheng Wang, Chung-Wen Kuo, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Huei-Jing Ke, Pei-Chen Kuo, Chin-Huei Lee, Jian-Ching Wu, Wen-Bin Lu, Ming-Hong Tai, Holger Jahr, Wei-Shiung Lian 2020 Sep 1;9(9):810. doi: 10.3390/antiox9090810. Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy. Antioxidants (Basel).
7. Tsu-Kung Lin, Shang-Der Chen, Kai-Jung Lin, Yao-Chung Chuang 2020 Oct 22;9(11):1029. doi: 10.3390/antiox9111029. Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial? Antioxidants (Basel).
8. Shih-Hsuan Chen, Chung-Wen Kuo, Tsu-Kung Lin, Meng-Han Tsai, Chia-Wei Liou 2020 Nov 20;9(11):1159. doi: 10.3390/antiox9111159. Dopamine Therapy and the Regulation of Oxidative Stress and Mitochondrial DNA Copy Number in Patients with Parkinson's Disease. Antioxidants (Basel).
9. Tsu-Kung Lin, Kai-Jung Lin, Kai-Lieh Lin, Chia-Wei Liou, Shang-Der Chen, Yao-Chung Chuang, Pei-Wen Wang, Jiin-Haur Chuang, Tzu-Jou Wang 2020 Nov 30;8:607392. doi: 10.3389/fcell.2020.607392. eCollection 2020. When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease. Front Cell Dev Biol.

2021年

1. Kai-Lieh Lin, Shang-Der Chen, Kai-Jung Lin, Chia-Wei Liou, Yao-Chung Chuang, Pei-Wen Wang, Jiin-Haur Chuang, Tsu-Kung Lin 2021 Mar 22;9:636295. doi: 10.3389/fcell.2021.636295. eCollection 2021. Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease. Front Cell Dev Biol.
2. Yu-Jih Su, Pei-Wen Wang, Shao-Wen Weng 2021 Mar 6;22(5):2668. doi: 10.3390/ijms22052668. The Role of Mitochondria in Immune-Cell-Mediated Tissue Regeneration and Ageing. Int J Mol Sci.
3. Chun-Yu Lin, Chun-Hsin Wu, Chung-Yuan Hsu, Tien-Hsing Chen, Ming-Shyan Lin, Yu-Sheng Lin, Yu-Jih Su 2021 Apr 23;12:641635. doi: 10.3389/fendo.2021.641635. eCollection 2021. Reduced Mortality Associated With the Use of Metformin Among Patients With Autoimmune Diseases. Front Endocrinol (Lausanne).
4. Tsu-Kung Lin, Kai-Jung Lin, Hung-Yu Lin, Kai-Lieh Lin, Min-Yu Lan, Pei-Wen Wang, Tzu-Jou Wang, Feng-Sheng Wang, Po-Chin Tsai, Chia-Wei Liou, Jiin-Haur Chuang 2021 Jul 7;14:697440. doi: 10.3389/fnmol.2021.697440. eCollection 2021. Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing α-Synuclein and Oxidative Stress. Front Mol Neurosci.
5. Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee 2021 Jul 21;11(8):689. doi: 10.3390/jpm11080689. Multiple Single Nucleotide Polymorphism Testing Improves the Prediction of Diabetic Retinopathy Risk with Type 2 Diabetes Mellitus J Pers Med.
6. Heng-Chung Kung, Kai-Jung Lin, Chia-Te Kung, Tsu-Kung Lin 2021 Jul 30;9(8):918. doi: 10.3390/biomedicines9080918. Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to R
7. esveratrol in Parkinson's Disease. Biomedicines.Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang 2021 Aug 4;10(8):1248. doi: 10.3390/antiox10081248. MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation. Antioxidants (Basel).
8. Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang 2021 Aug 24;22(17):9135. doi: 10.3390/ijms22179135. MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin. Int J Mol Sci.
9. Feng-Sheng Wang, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, Wei-Shiung Lian 2021 Aug 30;10(9):1394. doi: 10.3390/antiox10091394. Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics. Antioxidants (Basel).
10. Chia-Wei Liou, Shih-Hsuan Chen, Tsu-Kung Lin, Meng-Han Tsai, Chiung-Chih Chang 2021 Dec 10;10(12):1971. doi: 10.3390/antiox10121971. Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated with APOE4 Allele and Cholinesterase Inhibitor Therapy in Patients with Alzheimer's Disease. Antioxidants (Basel).
11. Kai-Jung Lin, Tzu-Jou Wang, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Jiin-Haur Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin 2021 Dec 2;10(12):1935. doi: 10.3390/antiox10121935. Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease-Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors. Antioxidants (Basel).

2022年

1. Nai-Ching Chen, Chien-Liang Chen, Feng-Chih Shen 2022 Jan 7;12(1):67. doi: 10.3390/jpm12010067.
   The Risk Factors of Severe Hypoglycemia in Older Patients with Dementia and Type 2 Diabetes Mellitus. J Pers Med.
2. Feng-Chih Shen, Shao-Wen Weng, Meng-Han Tsai, Yu-Jih Su, Sung-Chou Li, Shun-Jen Chang, Jung-Fu Chen, Yen-Hsiang Chang, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Ching-Yi Lin, Pei-Wen Wang 2022 Jan;13(1):201-208. doi: 10.1111/jdi.13629. Epub 2021 Aug 2.
   Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals. J Diabetes Investig.
3. Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin 2022 Feb 23;2022:1792894. doi: 10.1155/2022/1792894. eCollection 2022. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. Oxid Med Cell Longev.
4. Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko 2022 Apr 6;10(4):860. doi: 10.3390/biomedicines10040860.
   Gut Microbiota Ecosystem Governance of Host Inflammation, Mitochondrial Respiration and Skeletal Homeostasis. Biomedicines.
5. Shao-Wen Weng, Wen-Chieh Chen, Feng-Chih Shen, Pei-Wen Wang, Jung-Fu Chen, Chia-Wei Liou 2022 May 27;11(11):3033. doi: 10.3390/jcm11113033. Circulating Growth Differentiation Factor 15 Is Associated with Diabetic Neuropathy. J Clin Med.
6. Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang 2022 Jun 8;13(6):538. doi: 10.1038/s41419-022-04985-5. Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. Cell Death Dis.
7. Yu-Jih Su, Jing-Yang Huang, Cong-Qiu Chu, James Cheng-Chung Wei 2022 Jul 27;9:934184. doi: 10.3389/fmed.2022.934184. eCollection 2022. Sulfonylureas or biguanides is associated with a lower risk of rheumatoid arthritis in patients with diabetes: A nationwide cohort study. Front Med (Lausanne).
8. Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang 2022 Oct 24;11(21):3350. doi: 10.3390/cells11213350. A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics. Cells.

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