粒線體醫學研究中心
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粒線體醫學研究中心成立宗旨在於積極開發粒線體相關疾病分子診斷及移植療法，以達成治療粒線體相關之神經肌肉退化、免疫代謝異常、癌症、心血管疾病之精準且個人化醫學。
最新消息
2023年11月27日 特別演講公告
時間: 2023年11月27日PM12:00
地點:高雄長庚兒童醫院8樓學生教室（二）
主講者: 陽明交通大學藥理學研究所 李新城教授
主題：粒線體異常於人類癌症惡化進展的角色
時間: 2023年11月27日PM12:00
地點:高雄長庚兒童醫院8樓學生教室（二）
主講者: 陽明交通大學藥理學研究所 李新城教授
主題：粒線體異常於人類癌症惡化進展的角色
2023.10.28
中心成員林郁涵博士參加2023臺灣粒線體醫學暨研究學會 學術研討會暨年會壁報論文競賽，榮獲第三名佳績。
中心成員林郁涵博士參加2023臺灣粒線體醫學暨研究學會 學術研討會暨年會壁報論文競賽，榮獲第三名佳績。
2023.4.8 舉辦學術研討會
主題: 2023年高雄長庚粒線體與退化性疾病研討會
時間: 2023年4月8日 9:00-17:30
地點: 高雄長庚紀念醫院兒童醫院六樓紅廳
議程:近期公布
報名網址:近期公布
主題: 2023年高雄長庚粒線體與退化性疾病研討會
時間: 2023年4月8日 9:00-17:30
地點: 高雄長庚紀念醫院兒童醫院六樓紅廳
議程:近期公布
報名網址:近期公布
2023年4月8日舉辦學術研討會
主題: 2023年高雄長庚粒線體與退化性疾病研討會
時間: 2023年4月8日 9:30-17:00
地點: 高雄長庚紀念醫院兒童醫院六樓紅廳
報名網址:https://www.surveycake.com/s/09ozZ
議程:https://reurl.cc/mlRMpl
歡迎院內同仁報名參加！
2023.3.13 特別演講公告
時間: 2023年3月13日PM12:00
地點:Webex線上演講
主講者: 國立成功大學生物科技與產業科學系黃玲惠教授
主題: 膠原蛋白及透明質酸之生醫應用及在細胞治療應用的前景
會議網址: https://cgmh.webex.com/cgmh/j.php?MTID=m1c28b6a3e895885ef2c37ac254bb652b
簽到網址: https://www.surveycake.com/s/DPg6Y
主題: 2023年高雄長庚粒線體與退化性疾病研討會
時間: 2023年4月8日 9:30-17:00
地點: 高雄長庚紀念醫院兒童醫院六樓紅廳
報名網址:https://www.surveycake.com/s/09ozZ
議程:https://reurl.cc/mlRMpl
歡迎院內同仁報名參加！
2023.3.13 特別演講公告
時間: 2023年3月13日PM12:00
地點:Webex線上演講
主講者: 國立成功大學生物科技與產業科學系黃玲惠教授
主題: 膠原蛋白及透明質酸之生醫應用及在細胞治療應用的前景
會議網址: https://cgmh.webex.com/cgmh/j.php?MTID=m1c28b6a3e895885ef2c37ac254bb652b
簽到網址: https://www.surveycake.com/s/DPg6Y
2022.10.15
中心成員林祖功教授、沈峰志助理教授受邀於2022臺灣粒線體醫學暨研究學會學術研討會暨年會發表演說
中心成員林祖功教授、沈峰志助理教授受邀於2022臺灣粒線體醫學暨研究學會學術研討會暨年會發表演說
2022.10.15
恭喜王曉雯研究助理獲得2022臺灣粒線體醫學暨研究學會學術研討會暨年會海報論文競賽獲獎
恭喜王曉雯研究助理獲得2022臺灣粒線體醫學暨研究學會學術研討會暨年會海報論文競賽獲獎
2022.11.27
恭喜中心主任林祖功教授受邀於6th Taiwan International Conference of Parkinson’s Disease and Movement Disorder發表演講
2022.11.27
恭喜劉嘉為醫師團隊粒線體轉移在巴金森細胞粒線體轉移模型在台灣動障國際會議獲得海報銀獎
恭喜中心主任林祖功教授受邀於6th Taiwan International Conference of Parkinson’s Disease and Movement Disorder發表演講
2022.11.27
恭喜劉嘉為醫師團隊粒線體轉移在巴金森細胞粒線體轉移模型在台灣動障國際會議獲得海報銀獎
團隊成員
林祖功 主任
分機 407-2286
Ｅ-mail tklin@cloud.cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組及中心研究方向規劃
王逢興 副主任
分機 407-6406
Ｅ-mail wangfs@cgmh.org.tw
工作職掌 粒線體醫學研究中心相關研究方向規劃
李志宏 副主任
分機 407-2299
Ｅ-mail zieben@cgmh.org.tw
工作職掌 先天免疫疾病防治學組總主持人及中心研究方向規劃
劉嘉為
分機 407-2285
Ｅ-mail cwliou@cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組計畫主持人
傅睦惠
分機
Ｅ-mail k8601085@cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組計畫主持人
黃泰霖
分機 56056
Ｅ-mail victor99@cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組計畫主持人
沈峰志
分機 407-8302
Ｅ-mail carcinom@cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
李隆志
分機 407-8306
Ｅ-mail r5239@cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
莊錦豪
分機 407-8811
Ｅ-mail jhchuang@cloud.cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
莊蕙青
分機 56513
Ｅ-mail entjulia@cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
分機 407-2286
Ｅ-mail tklin@cloud.cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組及中心研究方向規劃
王逢興 副主任
分機 407-6406
Ｅ-mail wangfs@cgmh.org.tw
工作職掌 粒線體醫學研究中心相關研究方向規劃
李志宏 副主任
分機 407-2299
Ｅ-mail zieben@cgmh.org.tw
工作職掌 先天免疫疾病防治學組總主持人及中心研究方向規劃
劉嘉為
分機 407-2285
Ｅ-mail cwliou@cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組計畫主持人
傅睦惠
分機
Ｅ-mail k8601085@cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組計畫主持人
黃泰霖
分機 56056
Ｅ-mail victor99@cgmh.org.tw
工作職掌 粒線體疾病分子診斷及治療學組計畫主持人
沈峰志
分機 407-8302
Ｅ-mail carcinom@cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
李隆志
分機 407-8306
Ｅ-mail r5239@cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
莊錦豪
分機 407-8811
Ｅ-mail jhchuang@cloud.cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
莊蕙青
分機 56513
Ｅ-mail entjulia@cgmh.org.tw
工作職掌 先天免疫疾病防治學組計畫主持人
研究成果
2023年
Ya-Ling Yang, Ying-Hsien Huang, Feng-Sheng Wang, Ming-Chao Tsai, Chien-Hung Chen, Wei-Shiung Lian. 2023 Jul;67(13):e2200348. doi: 10.1002/mnfr.202200348. MicroRNA-29a Compromises Hepatic Adiposis and Gut Dysbiosis in High Fat Diet-Fed Mice via Downregulating Inflammation. Mol Nutr Food Res.
Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang. 2023 May;158:106394. doi: 10.1016/j.biocel.2023.106394. Inhibition of histone lysine demethylase 6A promotes chondrocytic activity and attenuates osteoarthritis development through repressing H3K27me3 enhancement of Wnt10a. Int J Biochem Cell Biol.
Shao-Wen Weng , Jian-Ching Wu, Feng-Chih Shen, Yen-Hsiang Chang, Yu-Jih Su, Wei-Shiung Lian, Ming-Hong Tai, Chia-Hao Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Tian-Huei Chu, Ying-Hsien Kao, Feng-Sheng Wang, Pei-Wen Wang. 2023 May;66(5):913-930. doi: 10.1007/s00125-023-05869-9. Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation. Diabetologia.
Jian-Ching Wu, Chao-Cheng Huang, Pei-Wen Wang, Ting-Ya Chen, Wen-Ming Hsu, Jiin-Haur Chuang, Hui-Ching Chuang. 2023 Jan 13;24(2):1649. doi: 10.3390/ijms24021649. ONC201 Suppresses Neuroblastoma Growth by Interrupting Mitochondrial Function and Reactivating Nuclear ATRX Expression While Decreasing MYCN. Int J Mol Sci.
2022年
Hui-Ching Chuang, Ming-Hsien Tsai, Yu-Tsai Lin, Ming-Huei Chou, Kun-Lin Yang, Chih-Yen Chien. 2022 Jan-Dec;21:15330338221146870. doi: 10.1177/15330338221146870. Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer. Technol Cancer Res Treat.
Kai-Jung Lin, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin. 2022 Nov 29;11(23):3829. doi: 10.3390/cells11233829. Iron Brain Menace: The Involvement of Ferroptosis in Parkinson Disease. Cells.
Kun-Siang Huang, Chun-Yu Chen, Chiao-Yin Sun, Yu-Jih Su 2022 Oct 1;85(10):993-999. doi: 10.1097/JCMA.0000000000000802. Serum parabens and its correlations with immunologic and cellular markers in Southern Taiwan industrialized city systemic lupus erythematosus patients. J Chin Med Assoc.
Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang 2022 Oct 24;11(21):3350. doi: 10.3390/cells11213350. A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics. Cells.
Yu-Jih Su, Jing-Yang Huang, Cong-Qiu Chu, James Cheng-Chung Wei 2022 Jul 27;9:934184. doi: 10.3389/fmed.2022.934184. eCollection 2022. Sulfonylureas or biguanides is associated with a lower risk of rheumatoid arthritis in patients with diabetes: A nationwide cohort study. Front Med (Lausanne).
Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang 2022 Jun 8;13(6):538. doi: 10.1038/s41419-022-04985-5. Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. Cell Death Dis.
Shao-Wen Weng, Wen-Chieh Chen, Feng-Chih Shen, Pei-Wen Wang, Jung-Fu Chen, Chia-Wei Liou 2022 May 27;11(11):3033. doi: 10.3390/jcm11113033. Circulating Growth Differentiation Factor 15 Is Associated with Diabetic Neuropathy. J Clin Med.
Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko 2022 Apr 6;10(4):860. doi: 10.3390/biomedicines10040860. Gut Microbiota Ecosystem Governance of Host Inflammation, Mitochondrial Respiration and Skeletal Homeostasis. Biomedicines.
Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin 2022 Feb 23;2022:1792894. doi: 10.1155/2022/1792894. eCollection 2022. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. Oxid Med Cell Longev.
Feng-Chih Shen, Shao-Wen Weng, Meng-Han Tsai, Yu-Jih Su, Sung-Chou Li, Shun-Jen Chang, Jung-Fu Chen, Yen-Hsiang Chang, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Ching-Yi Lin, Pei-Wen Wang 2022 Jan;13(1):201-208. doi: 10.1111/jdi.13629. Epub 2021 Aug 2. Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals. J Diabetes Investig.
Nai-Ching Chen, Chien-Liang Chen, Feng-Chih Shen 2022 Jan 7;12(1):67. doi: 10.3390/jpm12010067. The Risk Factors of Severe Hypoglycemia in Older Patients with Dementia and Type 2 Diabetes Mellitus. J Pers Med.
2021年
Kai-Jung Lin, Tzu-Jou Wang, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Jiin-Haur Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin 2021 Dec 2;10(12):1935. doi: 10.3390/antiox10121935. Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease-Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors. Antioxidants (Basel).
Chia-Wei Liou, Shih-Hsuan Chen, Tsu-Kung Lin, Meng-Han Tsai, Chiung-Chih Chang 2021 Dec 10;10(12):1971. doi: 10.3390/antiox10121971. Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated with APOE4 Allele and Cholinesterase Inhibitor Therapy in Patients with Alzheimer's Disease. Antioxidants (Basel).
Feng-Sheng Wang, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, Wei-Shiung Lian 2021 Aug 30;10(9):1394. doi: 10.3390/antiox10091394. Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics. Antioxidants (Basel).
Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang 2021 Aug 24;22(17):9135. doi: 10.3390/ijms22179135. MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin. Int J Mol Sci.
Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang 2021 Aug 4;10(8):1248. doi: 10.3390/antiox10081248. MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation. Antioxidants (Basel).
Heng-Chung Kung, Kai-Jung Lin, Chia-Te Kung, Tsu-Kung Lin 2021 Jul 30;9(8):918. doi: 10.3390/biomedicines9080918.Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson's Disease. Biomedicines.
Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee 2021 Jul 21;11(8):689. doi: 10.3390/jpm11080689. Multiple Single Nucleotide Polymorphism Testing Improves the Prediction of Diabetic Retinopathy Risk with Type 2 Diabetes Mellitus J Pers Med.
Tsu-Kung Lin, Kai-Jung Lin, Hung-Yu Lin, Kai-Lieh Lin, Min-Yu Lan, Pei-Wen Wang, Tzu-Jou Wang, Feng-Sheng Wang, Po-Chin Tsai, Chia-Wei Liou, Jiin-Haur Chuang 2021 Jul 7;14:697440. doi: 10.3389/fnmol.2021.697440. eCollection 2021. Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing α-Synuclein and Oxidative Stress. Front Mol Neurosci.
Chun-Yu Lin, Chun-Hsin Wu, Chung-Yuan Hsu, Tien-Hsing Chen, Ming-Shyan Lin, Yu-Sheng Lin, Yu-Jih Su 2021 Apr 23;12:641635. doi: 10.3389/fendo.2021.641635. eCollection 2021. Reduced Mortality Associated With the Use of Metformin Among Patients With Autoimmune Diseases. Front Endocrinol (Lausanne).
Yu-Jih Su, Pei-Wen Wang, Shao-Wen Weng 2021 Mar 6;22(5):2668. doi: 10.3390/ijms22052668. The Role of Mitochondria in Immune-Cell-Mediated Tissue Regeneration and Ageing. Int J Mol Sci.
Kai-Lieh Lin, Shang-Der Chen, Kai-Jung Lin, Chia-Wei Liou, Yao-Chung Chuang, Pei-Wen Wang, Jiin-Haur Chuang, Tsu-Kung Lin 2021 Mar 22;9:636295. doi: 10.3389/fcell.2021.636295. eCollection 2021.Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease. Front Cell Dev Biol.
2020年
Tsu-Kung Lin, Kai-Jung Lin, Kai-Lieh Lin, Chia-Wei Liou, Shang-Der Chen, Yao-Chung Chuang, Pei-Wen Wang, Jiin-Haur Chuang, Tzu-Jou Wang 2020 Nov 30;8:607392. doi: 10.3389/fcell.2020.607392. eCollection 2020. When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease. Front Cell Dev Biol.
Shih-Hsuan Chen, Chung-Wen Kuo, Tsu-Kung Lin, Meng-Han Tsai, Chia-Wei Liou 2020 Nov 20;9(11):1159. doi: 10.3390/antiox9111159. Dopamine Therapy and the Regulation of Oxidative Stress and Mitochondrial DNA Copy Number in Patients with Parkinson's Disease. Antioxidants (Basel).
Tsu-Kung Lin, Shang-Der Chen, Kai-Jung Lin, Yao-Chung Chuang 2020 Oct 22;9(11):1029. doi: 10.3390/antiox9111029. Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial? Antioxidants (Basel).
Feng-Sheng Wang, Chung-Wen Kuo, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Huei-Jing Ke, Pei-Chen Kuo, Chin-Huei Lee, Jian-Ching Wu, Wen-Bin Lu, Ming-Hong Tai, Holger Jahr, Wei-Shiung Lian 2020 Sep 1;9(9):810. doi: 10.3390/antiox9090810. Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy. Antioxidants (Basel).
Meng-Han Tsai, Chung-Wen Kuo, Tsu-Kung Lin, Chen-Jui Ho, Pei-Wen Wang, Jiin-Haur Chuang, Chia-Wei Liou 2020 Aug 11;9(8):1885. doi: 10.3390/cells9081885. Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population. Cells.
Hung-Yu Lin, Jiin-Haur Chuang, Pei-Wen Wang, Tsu-Kung Lin, Min-Tsui Wu, Wen-Ming Hsu, Hui-Ching Chuang 2020 Aug 19;9(9):1920. doi: 10.3390/cells9091920. 5-aza-2'-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma Cells.
Feng-Chih Shen, Ben-Chung Cheng, Jung-Fu Chen 2020 Jul-Aug;14(4):345-349. doi: 10.1016/j.orcp.2020.06.006. Epub 2020 Jul 9. Peri-renal fat thickness is positively associated with the urine albumin excretion rate in patients with type 2 diabetes. Obes Res Clin Pract.
Yen-Hsiang Chang, Hung-Yu Lin, Feng-Chih Shen, Yu-Jih Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Ching-Yi Lin, Shao-Wen Weng, Pei-Wen Wang 2020 Jul 29;11:445. doi: 10.3389/fendo.2020.00445. eCollection 2020. The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes. Front Endocrinol (Lausanne).
Hung-Yu Lin, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Wei-Shiung Lian, Ching-Hua Hsieh, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Chia-Shiang Chang, Ching-Yi Lin, Yu-Jih Su, Pei-Wen Wang 2020 Jul 10;33(2):66-86. doi: 10.1089/ars.2019.7737. Epub 2020 Feb 18. Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue. Antioxid Redox Signal.
Ya-Ling Yang, Ying-Hsien Huang, Feng-Sheng Wang, Ming-Chao Tsai, Chien-Hung Chen, Wei-Shiung Lian. 2023 Jul;67(13):e2200348. doi: 10.1002/mnfr.202200348. MicroRNA-29a Compromises Hepatic Adiposis and Gut Dysbiosis in High Fat Diet-Fed Mice via Downregulating Inflammation. Mol Nutr Food Res.
Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang. 2023 May;158:106394. doi: 10.1016/j.biocel.2023.106394. Inhibition of histone lysine demethylase 6A promotes chondrocytic activity and attenuates osteoarthritis development through repressing H3K27me3 enhancement of Wnt10a. Int J Biochem Cell Biol.
Shao-Wen Weng , Jian-Ching Wu, Feng-Chih Shen, Yen-Hsiang Chang, Yu-Jih Su, Wei-Shiung Lian, Ming-Hong Tai, Chia-Hao Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Tian-Huei Chu, Ying-Hsien Kao, Feng-Sheng Wang, Pei-Wen Wang. 2023 May;66(5):913-930. doi: 10.1007/s00125-023-05869-9. Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation. Diabetologia.
Jian-Ching Wu, Chao-Cheng Huang, Pei-Wen Wang, Ting-Ya Chen, Wen-Ming Hsu, Jiin-Haur Chuang, Hui-Ching Chuang. 2023 Jan 13;24(2):1649. doi: 10.3390/ijms24021649. ONC201 Suppresses Neuroblastoma Growth by Interrupting Mitochondrial Function and Reactivating Nuclear ATRX Expression While Decreasing MYCN. Int J Mol Sci.
2022年
Hui-Ching Chuang, Ming-Hsien Tsai, Yu-Tsai Lin, Ming-Huei Chou, Kun-Lin Yang, Chih-Yen Chien. 2022 Jan-Dec;21:15330338221146870. doi: 10.1177/15330338221146870. Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer. Technol Cancer Res Treat.
Kai-Jung Lin, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin. 2022 Nov 29;11(23):3829. doi: 10.3390/cells11233829. Iron Brain Menace: The Involvement of Ferroptosis in Parkinson Disease. Cells.
Kun-Siang Huang, Chun-Yu Chen, Chiao-Yin Sun, Yu-Jih Su 2022 Oct 1;85(10):993-999. doi: 10.1097/JCMA.0000000000000802. Serum parabens and its correlations with immunologic and cellular markers in Southern Taiwan industrialized city systemic lupus erythematosus patients. J Chin Med Assoc.
Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang 2022 Oct 24;11(21):3350. doi: 10.3390/cells11213350. A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics. Cells.
Yu-Jih Su, Jing-Yang Huang, Cong-Qiu Chu, James Cheng-Chung Wei 2022 Jul 27;9:934184. doi: 10.3389/fmed.2022.934184. eCollection 2022. Sulfonylureas or biguanides is associated with a lower risk of rheumatoid arthritis in patients with diabetes: A nationwide cohort study. Front Med (Lausanne).
Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang 2022 Jun 8;13(6):538. doi: 10.1038/s41419-022-04985-5. Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. Cell Death Dis.
Shao-Wen Weng, Wen-Chieh Chen, Feng-Chih Shen, Pei-Wen Wang, Jung-Fu Chen, Chia-Wei Liou 2022 May 27;11(11):3033. doi: 10.3390/jcm11113033. Circulating Growth Differentiation Factor 15 Is Associated with Diabetic Neuropathy. J Clin Med.
Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko 2022 Apr 6;10(4):860. doi: 10.3390/biomedicines10040860. Gut Microbiota Ecosystem Governance of Host Inflammation, Mitochondrial Respiration and Skeletal Homeostasis. Biomedicines.
Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin 2022 Feb 23;2022:1792894. doi: 10.1155/2022/1792894. eCollection 2022. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. Oxid Med Cell Longev.
Feng-Chih Shen, Shao-Wen Weng, Meng-Han Tsai, Yu-Jih Su, Sung-Chou Li, Shun-Jen Chang, Jung-Fu Chen, Yen-Hsiang Chang, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Ching-Yi Lin, Pei-Wen Wang 2022 Jan;13(1):201-208. doi: 10.1111/jdi.13629. Epub 2021 Aug 2. Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals. J Diabetes Investig.
Nai-Ching Chen, Chien-Liang Chen, Feng-Chih Shen 2022 Jan 7;12(1):67. doi: 10.3390/jpm12010067. The Risk Factors of Severe Hypoglycemia in Older Patients with Dementia and Type 2 Diabetes Mellitus. J Pers Med.
2021年
Kai-Jung Lin, Tzu-Jou Wang, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Jiin-Haur Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin 2021 Dec 2;10(12):1935. doi: 10.3390/antiox10121935. Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease-Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors. Antioxidants (Basel).
Chia-Wei Liou, Shih-Hsuan Chen, Tsu-Kung Lin, Meng-Han Tsai, Chiung-Chih Chang 2021 Dec 10;10(12):1971. doi: 10.3390/antiox10121971. Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated with APOE4 Allele and Cholinesterase Inhibitor Therapy in Patients with Alzheimer's Disease. Antioxidants (Basel).
Feng-Sheng Wang, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, Wei-Shiung Lian 2021 Aug 30;10(9):1394. doi: 10.3390/antiox10091394. Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics. Antioxidants (Basel).
Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang 2021 Aug 24;22(17):9135. doi: 10.3390/ijms22179135. MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin. Int J Mol Sci.
Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang 2021 Aug 4;10(8):1248. doi: 10.3390/antiox10081248. MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation. Antioxidants (Basel).
Heng-Chung Kung, Kai-Jung Lin, Chia-Te Kung, Tsu-Kung Lin 2021 Jul 30;9(8):918. doi: 10.3390/biomedicines9080918.Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson's Disease. Biomedicines.
Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee 2021 Jul 21;11(8):689. doi: 10.3390/jpm11080689. Multiple Single Nucleotide Polymorphism Testing Improves the Prediction of Diabetic Retinopathy Risk with Type 2 Diabetes Mellitus J Pers Med.
Tsu-Kung Lin, Kai-Jung Lin, Hung-Yu Lin, Kai-Lieh Lin, Min-Yu Lan, Pei-Wen Wang, Tzu-Jou Wang, Feng-Sheng Wang, Po-Chin Tsai, Chia-Wei Liou, Jiin-Haur Chuang 2021 Jul 7;14:697440. doi: 10.3389/fnmol.2021.697440. eCollection 2021. Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing α-Synuclein and Oxidative Stress. Front Mol Neurosci.
Chun-Yu Lin, Chun-Hsin Wu, Chung-Yuan Hsu, Tien-Hsing Chen, Ming-Shyan Lin, Yu-Sheng Lin, Yu-Jih Su 2021 Apr 23;12:641635. doi: 10.3389/fendo.2021.641635. eCollection 2021. Reduced Mortality Associated With the Use of Metformin Among Patients With Autoimmune Diseases. Front Endocrinol (Lausanne).
Yu-Jih Su, Pei-Wen Wang, Shao-Wen Weng 2021 Mar 6;22(5):2668. doi: 10.3390/ijms22052668. The Role of Mitochondria in Immune-Cell-Mediated Tissue Regeneration and Ageing. Int J Mol Sci.
Kai-Lieh Lin, Shang-Der Chen, Kai-Jung Lin, Chia-Wei Liou, Yao-Chung Chuang, Pei-Wen Wang, Jiin-Haur Chuang, Tsu-Kung Lin 2021 Mar 22;9:636295. doi: 10.3389/fcell.2021.636295. eCollection 2021.Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease. Front Cell Dev Biol.
2020年
Tsu-Kung Lin, Kai-Jung Lin, Kai-Lieh Lin, Chia-Wei Liou, Shang-Der Chen, Yao-Chung Chuang, Pei-Wen Wang, Jiin-Haur Chuang, Tzu-Jou Wang 2020 Nov 30;8:607392. doi: 10.3389/fcell.2020.607392. eCollection 2020. When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease. Front Cell Dev Biol.
Shih-Hsuan Chen, Chung-Wen Kuo, Tsu-Kung Lin, Meng-Han Tsai, Chia-Wei Liou 2020 Nov 20;9(11):1159. doi: 10.3390/antiox9111159. Dopamine Therapy and the Regulation of Oxidative Stress and Mitochondrial DNA Copy Number in Patients with Parkinson's Disease. Antioxidants (Basel).
Tsu-Kung Lin, Shang-Der Chen, Kai-Jung Lin, Yao-Chung Chuang 2020 Oct 22;9(11):1029. doi: 10.3390/antiox9111029. Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial? Antioxidants (Basel).
Feng-Sheng Wang, Chung-Wen Kuo, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Huei-Jing Ke, Pei-Chen Kuo, Chin-Huei Lee, Jian-Ching Wu, Wen-Bin Lu, Ming-Hong Tai, Holger Jahr, Wei-Shiung Lian 2020 Sep 1;9(9):810. doi: 10.3390/antiox9090810. Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy. Antioxidants (Basel).
Meng-Han Tsai, Chung-Wen Kuo, Tsu-Kung Lin, Chen-Jui Ho, Pei-Wen Wang, Jiin-Haur Chuang, Chia-Wei Liou 2020 Aug 11;9(8):1885. doi: 10.3390/cells9081885. Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population. Cells.
Hung-Yu Lin, Jiin-Haur Chuang, Pei-Wen Wang, Tsu-Kung Lin, Min-Tsui Wu, Wen-Ming Hsu, Hui-Ching Chuang 2020 Aug 19;9(9):1920. doi: 10.3390/cells9091920. 5-aza-2'-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma Cells.
Feng-Chih Shen, Ben-Chung Cheng, Jung-Fu Chen 2020 Jul-Aug;14(4):345-349. doi: 10.1016/j.orcp.2020.06.006. Epub 2020 Jul 9. Peri-renal fat thickness is positively associated with the urine albumin excretion rate in patients with type 2 diabetes. Obes Res Clin Pract.
Yen-Hsiang Chang, Hung-Yu Lin, Feng-Chih Shen, Yu-Jih Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Ching-Yi Lin, Shao-Wen Weng, Pei-Wen Wang 2020 Jul 29;11:445. doi: 10.3389/fendo.2020.00445. eCollection 2020. The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes. Front Endocrinol (Lausanne).
Hung-Yu Lin, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Wei-Shiung Lian, Ching-Hua Hsieh, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Chia-Shiang Chang, Ching-Yi Lin, Yu-Jih Su, Pei-Wen Wang 2020 Jul 10;33(2):66-86. doi: 10.1089/ars.2019.7737. Epub 2020 Feb 18. Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue. Antioxid Redox Signal.