Research Interests
    I am a dedicated researcher in the field of translational medicine, in the field of translational medicine, with a rich history of research experience and remarkable achievements. My mission, at the helm of my dynamic research team, is to delve into various research domains, encompassing immunology, rejuvenation, and drug discovery. My relentless pursuit of scientific excellence has yielded remarkable results, including the successful market introduction of our pharmaceutical product, with several others currently undergoing clinical trials in collaboration with esteemed pharmaceutical partners.

    My primary research focus orbits around the intricate interplay between immunity, anti-aging, and rejuvenation. In the relentless quest for the age-old dream of "eternal youth," nations worldwide are heavily investing in anti-aging and longevity research. Recently, my team at Keelung Chang Gung Hospital's Community Medicine Research Center achieved a groundbreaking milestone in anti-aging research. This transformative work was made possible through the development of a unique and patented longevity animal model, the Klf1K74R/K74R mouse. Employing precise genetic engineering, we altered the 74th amino acid of the hematopoietic stem cell regulator KLF1, replacing it with arginine (KLF1 K74R). Consequently, these mice exhibited significant extensions in lifespan, with the most exceptional individuals experiencing a remarkable 30% increase in longevity compared to ordinary mice.

    Furthermore, an in-depth analysis of specific immune cell populations in these genetically modified mice unveiled enhanced tumor infiltration by CD8+ T cells and natural killer T cells. This groundbreaking discovery prompted us to explore the potential of using lymphocytes from these engineered mice in cellular therapies for cancer, resulting in remarkable enhancements in both cancer resistance and overall survival. What adds to the intrigue of our research is the preservation of youthful physiology in these genetically modified mice as they age. Moreover, we have harnessed gene-modified cell therapy to achieve lifespan extension, treat solid cancers, and even realize rejuvenation effects. Our pioneering research has garnered multiple national patents.

    Turning to drug discovery and clinical research, another pivotal focus of my laboratory is to develop novel therapeutics for diseases such as hepatocellular carcinoma (HCC), immune-related disorders, Huntington's disease, and sepsis. We employ high-throughput screening methods, medical data analysis, and animal models to expedite the drug development process.

    In addition, I am responsible for planning and executing the recruitment for the Northeastern Taiwan Community Medicine Research Cohort (NTCMRC), registered with the identification number NCT04839796 on ClinicalTrials.gov. This comprehensive study on disease prevention and health promotion in the northeastern region of Taiwan, initiated in August 2013, aims to bridge the gap between clinical and basic research. My laboratory plays a crucial role in managing biological samples, questionnaire data, and medical records, thereby facilitating comprehensive and integrated research on disease prevention and community health.

    The integration of clinical and basic research is the hallmark of my endeavors. My commitment is to bridge the gap between these realms, drive scientific progress, and elevate healthcare quality. With a diverse array of research interests and an unwavering commitment to advancing medical knowledge and formulating innovative treatment approaches, my research team employs innovative and interdisciplinary approaches to explore the frontiers of medical science.

    As we forge ahead, we eagerly anticipate further breakthroughs, pushing the boundaries of scientific exploration. My research has earned international recognition and multiple patents, underscoring the transformative impact of my work in the fields of anti-aging and immunology. My unwavering dedication remains focused on advancing medical knowledge and improving healthcare for the betterment of society. With a deep-seated commitment to advancing healthcare, my laboratory stands at the forefront of translational medicine, bridging the gap between scientific discovery and real-world applications. My aspirations center around realizing healthier and longer lives for all.
Research Topics
1.長壽回春動物模型與其分子調控機制研究。
2.健康老化和東北角世代醫學研究。
3.藥物開發研究。
Research Technology
CyTOF質譜流式細胞分析技術、共軛焦顯微鏡 (Confocal microscopy)、Flow Cytometry、電子顯微鏡…等貴儀操作技術。醫學巨資料庫與實證醫學分析能力。實驗動物模型建立…等。

Selected Publications

1.Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice.
2.Tight Regulation of a Timed Nuclear Import Wave of EKLF by PKC theta and FOE during Pro-E to Baso-E Transition.
3.Chromatin-binding in vivo of the erythroid kruppel-like factor, EKLF, in the murine globin loci.
4.JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.
5.Prevalence rates of youths diagnosed with and medicated for ADHD in a nationwide survey in Taiwan from 2000 to 2011.