邱馨瑩 副研究員

所屬單位

高雄院區 基因體暨蛋白質體核心實驗室

專長領域

分子細胞生物學、疾病動物模式、腫瘤、脂肪、神經、肺等系統慢性發炎

電子郵件信箱

chiouhy@cgmh.org.tw

聯絡電話

(07)731-7123#8186

RESEARCH INTERESTS
Metabolic diseases including type 2 diabetes mellitus (T2DM) and obesity are increasingly cause severe economic and health burdens. Adipose tissue is critical for health energy homeostasis, and also has neuroendocrine and immune functions. In pathological conditions, the adipose tissues undergo compositional and functional remodeling, causing alternations in cytokine expressions, adipose tissue resident immune cell populations, and extracellular matrix composition. These changes profoundly induce consequences for systemic inflammation and insulin resistance, which is considered the leading cause of diabetes. Environmental factors, including diet and pollutants, are believed critical for the pathogenesis of metabolic diseases. My research goal is to explore the pathophysiology of adipose tissue dysfunction upon environmental factors exposure. The approaches include molecular biology, cell culture, transgenic mice, disease model, and -omics. Using these platforms, we   have explored a novel role of Endo180 on regulating diet-induced obesity, EMT and microenvironment regulation of gastric cancer. 

Research Topics
1. Environmental factors on genes and diseases
2. Cancer and tumor microenvironment

Selected Publications
1. Wang CW#, Chiou HY Clair# (co-first author), Chen SC, Wu DW, Lin HH, Chen HC, Liao WT, Lin MH*, Hung CH*, Kuo CH*
2. Chiou HY Clair#; Wang CW#; Chen SC; Tsai ML; Lin MH; Hung CH, Kuo CH (2023 Feb) Copper Exposure Induces Epithelial-Mesenchymal Transition-Related Fibrotic Change via Autophagy and Increase Risk of Lung Fibrosis in Human. Antioxidants 2023, 12(2), 532.
3. 3. Lin MH, Cheng PC, Hsiao PJ, Chen SC, Hung CH, Kuo CH, Huang SK, Chiou HY Clair*. The GLP-1 Receptor Agonist Exenatide Ameliorates Neuroinflammation, Locomotor Activity, and Anxiety-like Behavior in Mice with Diet-induced Obesity Through the Modulation of Microglia M2 Polarization and Downregulation of SR-A4. International Immunopharmacology. 2023;115:109653.
4. Chen HC, Chiou HY Clair, Tsai ML, Chen SC, Lin MH, Chuang TC, Hung CH, and Kuo CH. Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells. Frontiers in Pharmacology, 2022, 13:877125, PHARMACOLOGY & PHARMACY 2021 IF=5.988, R/C=50/279 (17.74% )
5. Chiu KJ#, Chiou HY Clair#(co-first author), Huang CH, Lu PC, Kuo HR, Wang JW, and Lin MH. Natural Compounds Targeting Cancer-Associated Fibroblasts against Digestive System Tumor Progression: Therapeutic Insights Biomedicines, 2022, 10 (3): 713
6. Chiou HY Clair, Huang SH, Hung CH, Tsai SM, Kuo HR, Huang YR, Wang JW, Chen SC, Kuo CH, Wu DC, Huang SK, Hsu SH and Lin MH*(2021, Aug) Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-CSF Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions Biomedicines 2021, 9(8), 943
7. Li CH#, Chiou HY Clair#(co-first author), Lin MH, Kuo CH, Lin YC*, Hung CH*, Kuo CH*(2021 Aug) Immunological Map in COVID-19 Journal of Microbiology, Immunology and Infection 2021;54(4):547-556.
8. Chiou HY Clair, Jiang HJ, Yang SF, Kuo KK, Lin PC, Hsiao PJ* (2020, Apr) Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study
9. Chiou HY Clair, Lin MW, Hsiao PJ, Chen CL, Chiao S, Chen YC, Lin TY, Wu DC, Lin MH* (2019, Mar). Dulaglutide modulates the development of tissue-infiltrating Th1/Th17 cells and the pathogenicity of encephalitogenic Th1 cells in the central nervous system. Int. J. Mol. Sci. 2019, 20(7), 1584
10. Hsiao PJ, Chiou HY Clair, Jiang HJ, Lee MY, Hsieh TJ, Kuo KK* (2017, Aug). Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis. Scientific Reports, 7(1):9030.

曾恩絨研究助理

Education
1999-2003  B.S. Department of Life Science, National Chung Hsing University, Taiwan
2003-2005  M.S. Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taiwan
2006-2014  Ph.D. Graduate Institute of Life Science, National Defense Medical Center, Taiwan

Professional affiliations
2014-2016  Postdoctoral Fellow, Department of Neurosurgery, Tri-Service General Hospital, Taiwan
2016-2019  Assistant Medical Investigator, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Taiwan
2019-2023  Assistant Medical Investigator, Teaching and Research Center, Siaogang Municipal Hospital, Taiwan

Academic Appointment
2019~Now  Adjunct Assistant Professor, Department of Applied Chemistry, National Chi-Nan University, Taiwan

Honors
2020 The award of outstanding Research, Tsai Ruei-Shiung Cultural and Educational Foundation, Taiwan
2019 Poster Award (Diabetes), Endocrinology and Diabetes Society, Taiwan
2018 Poster Award (Diabetes), Endocrinology and Diabetes Society, Taiwan
2018 Poster Award (Endocrine), Endocrinology and Diabetes Society, Taiwan
2014 Poster Award, The Chinese Society of Cell and Molecular Biology, Taiwan
2003 YIN,HSUN-JO Excellent Academic performance and thesis, Yang-Ming University, Taiwan

Research Support/Funding
NSC 112-2314-B-037 -066 (co-PI)
NSC 112-2314-B-037 -093 (co-PI)
NSC 111-2314-B-037-048-MY3 (co-PI)
NSC 110-2314-B-182A-160-MY3 (PI)
NSC 109-2314-B-037-034-MY3 (co-PI)
NSC 108-2320-B-037-003-MY2 (co-PI)
NSC 107-2314-B-650-015-MY3 (co-PI)