范文郎 副研究員
個人簡介
RESEARCH INTERESTS
Dr. Fan specializes in investigating the pathogenic genes of rare/complex diseases and identifying biomarkers for oral cancer, with a particular focus on understanding the genetic basis of disease inheritance and susceptibility, including rare diseases and cancer genetics. Their study involved mutational profiling of OCSCC tumors in 165 advanced patients, revealing frequent mutations in 10 oncogenic pathways, such as TP53, FAT1, and NOTCH1. Certain subgroups with specific alterations showed a negative impact on survival, indicating their clinical significance. The identification of multiple targetable mutations across various pathways suggests the potential for novel therapeutic approaches. Additionally, Dr. Fan explored the contribution of primary immunodeficiency disorder (PID)-associated genetic variants to childhood-onset systemic lupus erythematosus (cSLE), a condition characterized by a dysregulated immune response. Targeted sequencing identified damaging PID variants in 30.5% of cSLE patients, indicating their potential role in cSLE susceptibility. The study observed both dominant and recessive traits, along with higher mutation loads in cSLE patients compared to controls. These findings highlight the involvement of rare damaging variants in PID-related genes in the development of cSLE.
Research Topics
1. Genetic basis of human disease inheritance and susceptibility.
2. Bioinformatics.
代表著作
Selected Publications
1. Wu, C.Y., Fan, W.L., Yang, H.Y., Chu, P.S., Liao, P.C., Chen, L.C., Yao, T.C., Yeh, K.W., Ou, L.S., Lin, S.J., et al. (2023). Contribution of genetic variants associated with primary immunodeficiencies to childhood-onset systemic lupus erythematous. J Allergy Clin Immunol 151, 1123-1131.
2. Liao, C.T., Yang, L.Y., Lee, L.Y., Lin, C.Y., Wang, H.M., Ng, S.H., Yen, T.C., Fan, W.L., and Hsieh, J.C. (2021). Whole-exome sequencing identifies biosignatures that predict adverse survival outcomes in surgically treated patients with oral cavity squamous cell carcinoma. Oral oncology 122, 105547. (共同通訊)
3. Fan, W.L., Yang, L.Y., Hsieh, J.C., Lin, T.C., Lu, M.J., and Liao, C.T. (2021). Prognostic Genetic Biomarkers Based on Oncogenic Signaling Pathways for Outcome Prediction in Patients with Oral Cavity Squamous Cell Carcinoma. Cancers (Basel) 13. (第一)
4. Fan, W.L., Yeh, Y.M., Liu, T.T., Lin, W.M., Yang, T.Y., Lee, C.W., and Lin, T.C. (2021). Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression. Biomolecules 11. (第一)
5. Liao, C.T., Hsieh, C.H., Fan, W.L., Ng, S.H., Cheng, N.M., Lee, L.Y., Hsueh, C., Lin, C.Y., Fan, K.H., Wang, H.M., et al. (2020). A combined analysis of maximum standardized uptake value on FDG-PET, genetic markers, and clinicopathological risk factors in the prognostic stratification of patients with resected oral cavity squamous cell carcinoma. Eur J Nucl Med Mol Imaging 47, 84-93. (共同第一)
研究團隊
口腔癌
廖俊達醫師
謝佳訓醫師
系統性紅斑性狼瘡症
黃璟隆醫師
李文益醫師
曾敏華醫師
吳昭儀醫師
李美寰研究助理
心血管疾病
王朝永醫師
學術履歷
Education
1998-2002 B.Sc., Physics, Chung Yuan Christian University, Taoyuan, Taiwan
2002-2004 M.Sc., Physics, National Central University, Taoyuan, Taiwan
2004-2009 Ph.D., Physics, National Central University, Taoyuan, Taiwan
PROFESSIONAL AFFILIATIONS
2009-2013 Postdoctoral Research, Academia Sinica, Taipei, Taiwan
2013-2015 Manager, Innovation & Technology, Genomics bioSci & tech. Co., Ltd., New Taipei City, Taiwan
2015- 2018 Postdoctoral Research, Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital., Keelung, Taiwan
2018-2022 Assistant Research Fellow, Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital. Linkou, Taiwan.
2022-present Associate Research Fellow, Chang Gung Memorial Hospital, Kaohsiung Taiwan.