鄭再宏 副研究員

所屬單位

高雄院區 震波醫學與組織再造研究中心

專長領域

震波醫學、運動醫學、再生醫學、轉譯醫學、細胞生物學

電子郵件

cjh1106@cgmh.org.tw

連絡電話

(07)731-7123 #6422

RESEARCH INTERESTS
Our team primarily focuses on researching the principles and mechanisms of extracorporeal shockwave therapy (ESWT) to promotion of tissue regeneration. ESWT is a type of physical acoustic wave that can deliver energy to cell, tissue, and organ exerting reparative effects on injured tissues. The known theoretical foundations of ESWT include promoting angiogenesis, anti-inflammatory responses, regulating immune cell activity, and activating stem cells, among others. In addition, our team conducts experiments in the field of stem cell regenerative medicine, integrating ESWT to treat musculoskeletal-related disorders. Currently, our laboratory employs several rat disease models, such as osteoarthritis, osteonecrosis of femoral head, osteoporosis, and spinal cord injury.

Research Topics
震波醫學、運動醫學、再生醫學、轉譯醫學、細胞生物學

Licensers                                                                        
105年度中華民國專利”衍生自雞貧血病毒(CAV) VP2蛋白質的細胞核定位信號胜肽以及它們的應用”。專利證書號碼及發明人: I515203/李孟修, 鄭再宏, 連一洋。專利期限: 2016/1/1~2032/7/22。

Selected Publications
1. Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head. Hsu SL, Jhan SW, Hsu CC, Wu YN, Wu KLH, Kuo CA, Chiu HW, Cheng JH*. Biomed J. 2023. Volume 46, Issue 6, December 2023, 100571. 指導作者。
2. Genetic Authentication of the Medicinal Plant Portulaca oleracea Using a Quick, Precise, and Sensitive Isothermal DNA Amplification Assay. Xu MR, Sun FC, Yang BC, Chen HJ, Lin CH, Cheng JH, Lee MS. Int J Mol Sci. 2023 Jun 27;24(13):10730.
3. A novel therapeutic approach for endometriosis using adipose-derived stem cell-derived conditioned medium- A new hope for endometriotic patients in improving fertility. Huang SJ, Huang CY, Huang YH, Cheng JH, Yu YC, Lai JC, Hung YP, Chang CC, Shiu LY. Front Endocrinol (Lausanne). 2023 May 24;14:1158527.
4. Effects of platelet-rich plasma glue placement at the prostatectomy site on erectile function restoration and cavernous nerve preservation in a nerve-sparing prostatectomy rat model. Liao CH, Chang CJ, Chen KC, Rajneesh CP, Tseng XW, Cheng JH, Chiang HS, Wu YN. Biomed Pharmacother. 2023 May;161:114499.
5. Development of a specific and sensitive diagnostic PCR for rapid molecular authentication of the medicinal plant Portulaca oleracea. Xu MR, Lee MS, Yang BC, Chang HC, Kuo CL, Lin CH, Chen HJ, Cheng JH, Sun FC. Mol Cell Probes. 2023 Feb;67:101890.
6. Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling. Peng JM, Chiu CF, Cheng JH, Liu HY, Chang YL, Luo JW, Weng YT, Luo HL. Front Immunol. 2022 Aug 11;13:883178.
7. Chang CC, Wu SY, Lai YR, Hung YC, Hsu CY, Chen HJ, Chu CC, Cheng JH, Hu WL, Kuo CA. The Utilization of Chinese Herbal Products for Hyperthyroidism in National Health Insurance System (NHIRD) of Taiwan: A Population-Based Study. Evid Based Complement Alternat Med. 2022 Mar 19;2022:5500604.
8. Liao CH, Lee KH, Chung SD, Chen KC, Praveen Rajneesh C, Chen BH, Cheng JH, Lin WY, Chiang HS, Wu YN. Intracavernous Injection of Platelet-Rich Plasma Therapy Enhances Erectile Function and Decreases the Mortality Rate in Streptozotocin-Induced Diabetic Rats. Int J Mol Sci. 2022 Mar 10;23(6):3017.
9. Chen PY, Cheng JH, Wu ZS, Chuang YC. New Frontiers of Extracorporeal Shock Wave Medicine in Urology from Bench to Clinical Studies. Biomedicines. 2022 Mar 15;10(3):675. 共同第一作者
10. Chung SD, Praveen Rajneesh C, Chen KC, Tai HC, Chang ML, Tseng XW, Cheng JH, Tsai WK, Chiang HS, Wu YN. Specific Impacts of Ketamine on Bladder Dysfunction and Associated Histological Alterations in Rats-A Time Course Validation through Transmission Electron Microscopy. Int J Mol Sci. 2022 Feb 16;23(4):2194.
11. Cheng YH, Tsai NC, Chen YJ, Weng PL, Chang YC, Cheng JH, Ko JY, Kang HY, Lan KC. Extracorporeal Shock Wave Therapy Combined with Platelet-Rich Plasma during Preventive and Therapeutic Stages of Intrauterine Adhesion in a Rat Model. Biomedicines. 2022 Feb 17;10(2):476.
12. Jhan SW, Wang CJ, Wu KT, Siu KK, Ko JY, Huang WC, Chou WY*, Cheng JH*. Comparison of Extracorporeal Shockwave Therapy with Non-Steroid Anti-Inflammatory Drugs and Intra-Articular Hyaluronic Acid Injection for Early Osteoarthritis of the Knees. Biomedicines. 2022 Jan 18;10(2):202. *correspondence
13. Jai-Hong Cheng, Wen-Yi Chou, Ching-Jen Wang, Ka-Kit Siu, Jei-Ming Peng, Yi-No Wu, Meng-Shiou Lee, Chien-Yiu Huang, Jih-Yang Ko, Shun-Wun Jhan. Pathological, Morphometric and Correlation Analysis of the Modified Mankin Score, Tidemark Roughness and Calcified Cartilage Thickness in Rat Knee Osteoarthritis after Extracorporeal Shockwave Therapy. Int. J. Med. Sci. 2022; 19(2): 242-256. doi:10.7150/ijms.67741. (SCIE; Impact Factor: 3.738, MEDICINE, GENERAL & INTERNAL, Rank: 45/154, 29%).第一作者。
14. Peng JM, Chen WY, Cheng JH, Luo JW, Tzeng HT. Dysregulation of Cytoskeleton Remodeling Drives Invasive Leading Cells Detachment. Cancers (Basel). 2021 Nov 11;13(22):5648.
15. Cheng JH, Hsu CC, Hsu SL, Chou WY, Wu YN, Kuo CA, Hsu TC, Shiu LY, Jhan SW. Adipose-Derived Mesenchymal Stem Cells-Conditioned Medium Modulates the Expression of Inflammation Induced Bone Morphogenetic Protein-2, -5 and -6 as Well as Compared with Shockwave Therapy on Rat Knee Osteoarthritis. Biomedicines. 2021 Oct 5;9(10):1399.第一作者。
16. Cheng JH, Jhan SW, Hsu CC, Chiu HW, Hsu SL. Extracorporeal Shockwave Therapy Modulates the Expressions of Proinflammatory Cytokines IL33 and IL17A, and Their Receptors ST2 and IL17RA, within the Articular Cartilage in Early Avascular Necrosis of the Femoral Head in a Rat Model. Mediators Inflamm. 2021 Jul 9;2021:9915877. 第一作者。
17. Peng JM, Hsieh SY, Cheng JH, Luo JW, Su YL, Luo HL. Confirming whether KLHL23 deficiency potentiates migration in urothelial carcinoma. Chin J Physiol. 2021 May-Jun;64(3):142-149. (70/81=86%)
18. Cheng JH, Yen KT, Chou WY, Jhan SW, Hsu SL, Ko JY, Wang CJ, Kuo CA, Wu SY, Hsu TC, Hsu CC. Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint. Pharmaceuticals (Basel). 2021 Apr 1;14(4):318.第一作者。

Books
1. 專書書名: Translational Research in Biomedicine -Shockwave Medicine. Vol. 6 , 2018. Section II: Musculoskeletal Disorders, Development of Extracorporeal Shockwave Therapy for Treatment of Osteonecrosis of the Femoral Head. Cheng, J.-H.; Hsu, S.-L.; Wang, C.-J. (Kaohsiung)。
2. 鄭再宏. 竹嵌紋病毒核酸基因體3'非轉譯區在其複製過程中結構與功能分析的研究. (The Structural and Functional Characterization of the 3' Untranslated Region of Bamboo mosaic virus RNA in its replication cycle.) 2004. (博士論文)
3. 鄭再宏. 竹嵌紋病毒核酸基因體合成負股核酸啟動子的分析. (The promoter activity of bamboo mosaic potexvirus RNA for Minus-strand RNA synthesis in vitro by RNA-Dependent RNA polymerase.) 1998. (碩士論文)

震波醫學
周文毅醫師、徐山琳醫師、許傑程醫師、吳冠廷醫師、詹舜文醫師、陳政葦醫師

運動醫學
周文毅醫師、吳冠廷醫師、陳柏成醫師

中醫學
郭純恩醫師、吳思穎醫師

牙科學
蔡佳玲醫師、陳禎醫師、張鈺佳醫師

Education
Ph. D.: Graduate Institute of Biotechnology, National Chung Hsing University (1998-2004)
M.S.: Graduate Institute of Biotechnology, National Chung Hsing University (1996-1998)
B.S.: School of Medical Technology, Chung Shan Medical and Dental College (1992-1996)

PROFESSIONAL AFFILIATIONS
1. International Society for Medical Shockwave Treatment (ISMST)會員。
2. ONLAT Ibero-American Federation honorary member。
3. 中華民國生理學會。
4. 台灣骨科研究學會。
5. 台灣內耳治療學會。
6. 台灣細胞生物力學學會。
7. 中華民國生物物理學會會員。

Academic Appointment
Associate research fellow: Department of Medical Research, Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung (2020-Present)                         
                                                                                                      
HONORS                                                                                                                    
2017 ISMST Awards to the Best Original Works on ESWT Basic Research

Research Support/Funding