連韋雄 副研究員

所屬單位

高雄院區 型態鑑定暨病原診斷核心實驗室

專長領域

骨骼肌肉生理、表觀基因組學、分子生物學、實驗動物疾病模式

電子郵件

lianws@cgmh.org.tw

連絡電話

(07)731-7123 #6405

RESEARCH INTERESTS 

1. Epigenetic Regulation in Osteoarthritis (OA):
1-1 Investigating DNA methylation and histone modifications in OA progression.
1-2 Examining the role of microRNAs in the epigenetic control of gene expression in OA.
1-3 Identifying epigenetic markers as potential diagnostic or prognostic indicators for OA severity.

2. Epigenetic Regulation of Mitochondrial Function in Joint Diseases:
2-1 Studying how epigenetic modifications influence mitochondrial gene expression in joint tissues.
2-2 Investigating the interplay between epigenetics and mitochondrial dysfunction in OA and osteoporosis.
2-3 Identifying epigenetic interventions to modulate mitochondrial function and alleviate joint diseases.

3. Integrative Epigenomics in Musculoskeletal Disorders:
3-1 Developing comprehensive epigenomic maps for joint tissues affected by OA and osteoporosis.
3-2 Integrating multi-omics data (epigenomics, transcriptomics, and proteomics) to unravel complex molecular pathways.
3-3 Applying systems biology approaches to understand the holistic impact of epigenetic changes on mitochondrial function in musculoskeletal disorders.

Conference Papers and Presentations      

1.Lian WS (2023, Sep). The Role of Histone Modifiers and Oxidative Stress in Osteoarthritis. The virtual 31st Annual Meeting of the European Orthopaedic Research Society (EORS), Portugal/Porto. Invited speaker.
2. Lian WS (2022, Sep). The role of gut ecosystem in the development of osteoarthritis: friend or foe. The International Combined Orthopaedic Research Societies (ICORS), Edinburgh. Invited presentation.
3.Lian WS (2021, Sep) The virtual 29th Annual Meeting of the European Orthopaedic Research Society (EORS), Rome. Invited speaker/ Title: Effects of Fndc5-derived hormone-like myokines on cartilage metabolism.
3. Lian WS (2020, Sep). Systemic modulation of global epigenetic programming and the composition of metabolites in aging promotes osteoarthritis. The virtual 28th Annual Meeting of the European Orthopaedic Research Society (EORS), Izmir/Turkey. Presentation and Chair Invited.
4. Lian WS (2019, Oct). Methylated Histone Pathway Modulation of Cartilage Integrity and Osteoarthritis. 27th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS), Maastricht/Netherlands. Invited presentation.
5. Lian WS (2019, Jun). Trimethyl H3K27 Assembly Modulation of Cartilage Integrity and Osteoarthritis. 2nd International Combined Orthopaedic Research Society (ICORS), Montreal/Canada. Invited presentation.

骨骼肌肉研究團隊
巫瑞文醫師
王逢興博士
郭繼陽醫師

肝癌研究團隊
陳建宏醫師
蔡明釗醫師
郭垣宏醫師