王逢興 研究員

所屬單位

高雄院區 醫學研究部

專長領域

表觀基因(Epigenetics); 細胞代謝、 骨骼關節細胞生物醫學、 間質幹細胞生理學、  多體學(multi-omics)、基因修飾動物、疾病模式

電子郵件

wangfs@cgmh.org.tw; wangfs@ms33.hine.net; wangfs6672@gmail.com

連絡電話

(07)731-7123 #6672

Research interest
I immerse myself in studying the epigenetic control and metabolomic regulation of degenerative skeletal disorders, especially osteoporosis and osteoarthritis. My collective findings shed light onto microRNA functions, DNA methylation, and histone modification, including post-translational acetylation, methylation, and cronylation of lysine and arginine residues for chromatin remodeling, which affects epigenome, microRNAome, and transcriptome, and secretome landscapes during mesenchymal stem cells turn out to be bone-, cartilage, and adipose-forming cells or hematopoietic progenitor cells shift into bone-resorbing cells. Currently, I center on generating novel tissue specific double/triple gene knockout mouse models, conveying productive insight into how mitochondrial metabolites, like TCA cycle and beta-oxidation change epigenetic histone lysine/arginine demethylase function and histone reading bromodomain-containing protein pathways during tissue homeostasis and deterioration. Arrays of findings prompt my team to work out plenty of novel disease modifying options using biochemical or electrophysical, or nanoparticle ways, which have been patented or collaborated with physicians. 

Research topics 
Histone lysine/arginine methylation in osteoporosis development
Histone lysine methylation in bone-resorbing cells during osteoarthritis
Mitochondrial metabolism dysregulation in post-translational modification of histone

Selected Publications
1.    Lian WS, Wu RW, Ko JY, Chen YS, Wang SY, Jahr H, Wang FS*. Inhibition of histone lysine demethylase 6A mitigates chondrocyte dysfunction and delays osteoarthritis through H3K27me3 repression of Wnt10a. The International Journal of Biochemistry & Cell Biology 2023;158:106394. 
2.    Wen SW, Wu JC, Shen FC, Chang YH, Su YJ, Lian WS, Tai MH, Su CH, Chung JH, Lin TK, Liou CW, Chu TH, Kao YH, Wang FS*, Wang PW*. Chaperonin counteracts diet-induced nonalcoholic fatty liver disease (NAFLD) through escorting SIRT3 control of fatty acid oxidation. Diabetologia 2023;66:913-930.
3.    Lian WS, Wu RW, Ko JY, Chen YS, Wang SY, Yu CP, Jahr H, Wang FS*. UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. Cell Death and Disease 2022;13:538.
4.    Lian WS, Wu RW, Chen YS, Ko JY, Wang SY, Jahr H, Wang FS*. MicroRNA-29a mitigates osteoblast senescence and counteracts bone loss through oxidation resistance-1 control of FoxO3 methylation. Antioxidants 2021;10:1248
5.    Lian WS, Kuo CW, Ko HY, Ke HJ, Chen YS, Wang SY, Kuo PC, Tai MH, Jahr H, Wang FS*. Irisin represses oxidative stress and mitigates osteoarthritis development through regulating mitochondrial function and autophagy. Antioxidant 2020;9:E810.
6.    Lian WS, Ko JY, Chen YS, Ke HJ, Hiseh CK, Kuo CW, Wang SY, Huang BW, Tseng JG, Wang FS*. MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12. Cell Death & Disease 2019;10:705
7.    Lian WS, Ko JY, Wu RW, Sun YC, Chen YS, Wu SL, Weng LH, Jahr H, Wang FS*. MicroRNA-128 repressed chondrocyte autophagy exacerbates knee osteoarthritis by disrupting Atg12. Cell Death & Disease 2018;9:919
8.    Lian WS, Ko JY, Chen YS, Ke HJ, Wu SL, Kuo CW, Wang FS*. Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR. Cell Death & Disease 2018;9:938.
9.    Wang FS, Wu RW, Lain WS, Tsai TC, Chen YS, Sun YC, Ke HJ, Li JC, Hwang JL, Ko JY. Sclerostin vaccination mitigates estrogen deficiency induction of bone mass loss and microstructure deterioration. Bone 2018;112:24-34.
10.    Wang FS, Lian WS, Weng WT, Chen YS, Sun YC, Wu SL, Ko JY. Histone Demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and –independent pathways. Journal Molecule Medicine 2017;95:499-512
11.    Ko JY, Sun YC, Li WC, Wang FS*. Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis. Journal of Molecular Medicine 2016;94:755-769.
12.    Ko JY, Chuang PC, Su WH, Ke HC, Chen YS, Sun YC, Wang FS*. MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation. Bone 2015;81:80-88
13.    Lin CL, Lee PH, Lei CC, Hsu YC, Wang JY, Huang YT, Wang SY, Wang FS*. Cannabinoid receptor 1 disturbance of PPARγ2 augments hyperglycermia induction of mesangial inflammation and fibrosis in renal glomeruli. Journal of Molecular Medicine 2014 2014;92:779-792.
14.    Lin CL, Lee PH, Hsu YC, Lei CC, Ko JY, Chuang PC, Huang YT, Wang SY, Chen YS, Chiang WC, Reiser J, Wang FS*. MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. Journal of the American Society of Nephrology 2014;25:1698-1709.
15.    Wang FS, Lin CL, Chen MW, Ke, HC, Chang YH, Ko JY. MicroRNA miR-29a protects from glucocorticoid-induced bone loss and fragility by orchestrating bone acquisition and resorption. Arthritis and Rheumatism 2013;65:1530-1540.
16.    Weng LH, Ko JY, Wang CJ, Sun YC, Wang FS*. Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints. Arthritis & Rheumatism 2012;64:3267-3277.
17.    Ko JY, Wu RW, Kuo SJ, Chen MW, Yeh DW, Ke HC Wu SL, Wang FS*. Cannabinoid receptor 1 mediates glucocorticoid-induced bone loss in rats by perturbing bone mineral acquisition and marrow adipogenesis. Arthritis & Rheumatism 2012;64:1094-1104.

Books
1.    Wang FS, Lian SW, Kuo CW 2019 Heat shock protein 60 regulation of skeletal tissue integrity. Asea AAA, Kaur P, Springer Nature. 
2.    Wang FS, Shu KY, Lin WC, Cheng YK. 2018 Laboratory Animal Facility Management (Chinese).

Patents and intellectual Property
1.    王逢興、郭繼陽、黃柏文、曾仲葛、巫瑞文、林政宏、連韋雄、謝進貴。無線攜帶式可調控低頻振波骨細胞增生系統。中華民國專利證書新型第M563251號。
2.    王逢興、郭繼陽、黃柏文、曾仲葛、陳品任、邱煜憲。可調控低頻振波骨細胞增生儀。中華民國專利證書新型第M487051號
3.    Wang FS. 2020. FVB/N-Tg(PGK-Cnr1)Wfs/Narl. Rodent Model Resource Center, Taiwan
4.    Wang FS. 2019. FVB/N-Tg(PGK-miR29a )Wfs/Narl. Rodent Model Resource Center, Taiwan
5.    Wang FS. 2018. FVB/N-Tg(PGK-HSPD1)Wfs/Narl. Rodent Model Resource Center. Taiwan

Conference Papers and Presentations
1.    Wang FS. New insights into osteoporosis development. Symposium for Sarcopenia. The 8th Asian Federation of Osteoporosis Societies Congress & The 26th Taiwan Osteoporosis Association Scientific Conference. 14 October 2023, Linko, Taiwan. 
2.    Wang FS. Novel insights from the gut-joint axis: the contribution of gut microflora and metabolites to cartilage homeostasis. Symposium for Novel Insights into Osteoarthritis and Cartilage Regeneration. The 31st Annual Meeting of European Orthopedic Research Society, 27-29 September 2023, Porto, Portugal.
3.    Wang FS. To be or not to be methylated. The dilemma over the histone H3K27 action to osteoporosis development. 2023 Biomedical Research Symposium of National Health Research Institutes, 9-10 August 2023, Miaoli, Taiwan.
4.    Wang FS. Mitochondrial bioenergetics and metabolism in chondrocyte function and osteoarthritis development. Mouse Molecular Genetics (MMG) Symposium 2022. 30 September 2022, Taipei, Taiwan. 
5.    Wang FS. Gut microbiota-derived metabolites regulate obesity-induced bone and joint tissue damage. Workshop for New Focus Area in Osteoarthritis Research. World Congress of Orthopaedic Research, 7-9 September 2022, Edinburg, UK. 
6.    Wang FS. The role of bio-active molecules in bone and cartilage pathobiology (Virtual presentation). Symposium of Bone and Cartilage-Pathophysiological Microenvironmental Cues. The 29th Annual Meeting of European Orthopedic Research Society, 15-17 September 2021, Rome, Italy.
7.    Wang FS. Irisin is a senolytic agent in chondrocytes and osteoarthritis. Symposium of The Role of Adipomyokines in Musculoskeletal Diseases. Symposium of Bone and Cartilage-Pathophysiological Microenvironmental Cues. The 29th Annual Meeting of European Orthopedic Research Society, 15-17 September 2021, Rome, Italy.
8.    Wang FS. Exercise myokine counteracts chondrocyte senescence and osteoarthritis development through mitochondrial metabolism reprogramming. World Conference of Osteoarthritis Research Society International (OARSI)-Webinar Presentation, 28-29 April 2021.
9.    Wang FS. Epigenetic control of bone and fat metabolism. The 42nd Annual Meeting of the Endocrine Society and the Diabetes Association of the ROC (Taiwan), 27-28 March 2021, Taipei, Taiwan.
10.    Wang FS. Metabolite regulation of subcellular organelle function to chondrocyte activity and osteoarthritis development. Special Symposium of metabolic insights into chondrocyte function and osteoarthritis therapies. The 28th Annual Congress of European Orthopaedic Research Society (EORS)-Virtual Congress, 17 -18 September 2020.   
11.    Wang FS. Epigenetic control and therapeutic potential of osteoporosis and osteoarthritis. The 5th Annual Meeting of Taiwan Bone Muscle Joint Total Care Association, 14 September 2020, Taipei, Taiwan.
12.    Wang FS. MicroRNA-29a protects against chondrocyte senescence and osteoarthritis development through improving FoxO3 methylation. World Conference of Osteoarthritis Research Society International (OARSI)-Webinar Presentation, 2 September 2020.
13.    Wang FS. MicroRNA regulation of articular homeostasis and osteoarthritis. Symposium of cartilage microenvironment and OA: impact on treatment options. 27th Annual Meeting European Orthopedic Research Society, 2-4 October 2019, Masstricht, The Netherlands.
14.    Wang FS. MicroRNA control of chondrocyte fate and osteoarthritis development. ICORS Workshop-emerging molecular therapeutic potentials for treating osteoarthritis. The 2nd Triennial International Combined Orthopaedic Research Societies (ICORS) Meeting, 19-22 June 2019, Montreal, Canada. 
15.    Wang FS. MicroRNA-128 impairs cartilage integrity and deteriorates osteoarthritis pathogenesis through deregulating chondrocyte autophagy. 2018 Annual Meeting of American College of Rheumatology, 20-24 October 2018, Chicago, USA. 

軟骨生理學、菌相生物醫學、多體學生物資訊
連韋雄博士

粒線體生物醫學、脂肪代謝
林郁涵博士

奈米、胞外體生物醫學
呂承烋博士

臨床醫學
骨科-巫瑞文醫師、郭繼陽醫師
兒童內科-洪碧蓮醫師、林宜君醫師
兒童外科-江俊宏醫師
胸腔內科-林孟志醫師、陳友木醫師
中醫-高照為醫師

跨（國）院際合作
生物醫學-戴明泓教授、溫志宏教授（國立中山大學）
醫學工程-黃柏文教授（正修大學）
生物化學-蔡美玲教授、孫珮珮教授（國立高雄科技大學）
生物材料-Dr. Holger Jahr, Department of Anatomy and Cell Biology, University Hospital RWTH Aachen, Germany
腸菌代謝醫學-Dr. Dirk Heller, Institute for Food Health ZIEL, Techische University Muchen, Germany
表觀基因醫學-Dr. Cheng-Ming Chiang（玉山學者）Department of Pharmacology, Texas Southwestern Medical Center, Dallas, USA
人工智慧-Dr. Bernd Grimm, Luxembourg Institute of Health, Luxembourg

核心技術
貴儀（顯微電腦斷層、活體代謝）、分子生物-陳于珊
基因修飾動物-王紹諭
動物型態（行為、生物力學、運動、疼痛）-陳妍伶、李金玲、楊淨雯
細胞生理-吳欣龍、蔡采臻
組織學型態-林美瑤、陳于惠
基因藥理調控-羅志恩、陳芳怡

Education
1992-1995 Ph.D. in Animal Science, National Taiwan University, Taipei
1999-2001 Postdoctoral Fellow in Stem Cell Biology, KCGMH

Professional Affiliations
2021- Deputy Chairman, Research Project Review Committee, KCGMH
2018- Deputy Chairman, Institutional Animal Care and Use Committee, KCGMH
2021- Director, Core Laboratory for Gnotobiotic Medicine, KCGMH
2015- Director, Core Laboratory for Phenomics & Diagnostics, KCGMH
2011- Full Investigator, Department of Medical Research, KCGMH
2010- Director, Center for Laboratory Animals, KCGMH

Academic Appointment
2010- Adjunct Professor, Graduate Institute of Clinical Medical Sciences, CGU
2022- Council Member, Taiwan Orthopedic Research
2021- Scientific Committee Member, ICORS
2020- Taiwan Ambassador for European Orthopedic Research Society (EORS)
2019-2021 Review Committee Member, Ministry of Science & Technology, Taiwan
2019- Scientific Committee Member, EORS
2016- Associate Editor, Clinical Orthopaedic Related Research
2008- Editorial Board Member, Acta Pharmacologica Sinica

Honors and Awards
2023, 2022, 2021, World's Top 2% Scientist-Scientific Impact & Lifelong Impact
2023- Fellow of International Combined Orthopedic Research Society (ICORS)
2023 Sigma Xi The Scientific Research Honor Society
2022 Outstanding Innovative Research Grant Award, National Health Research Institute (NHRI), Taiwan
2020 Continuation Innovative Research Grant Award, NHRI
2020 Top Award, 2020 Osteoarthritis Research Society International (OARSI)
2017, 2018, 2019 Outstanding Reviewer Award, Acta Pharmacologica Sinica
2017 Outstanding Contribution in Reviewing Award 2017, Bone
2016 Top Reviewer Award, Clinical Orthopaedic Related Research

Research Funding
2002- National Science & Technology Council (Ministry of Science & Technology; National Science Council)
2002- National Health Research Institute, Taiwan
2008- Chang Gung Memorial Hospital
2018- Taiwan Mouse Clinic and Animal Consortium-National Comprehensive Mouse Phenotyping and Drug Testing Center (Subcomponent project for core facility)