莊佩錦研究員

所屬單位

高雄院區 醫學研究部

專長領域

輻射生物學、輻射阻抗性機制研究、訊息傳遞學

電子郵件

stemcorelab@cgmh.org.tw

連絡電話

(07)731-7123 #8090

Research Interests:

   My research theme in the past five years are including two parts. The first part is primarily focused on mechanistic study of controlling the development and propagation of hormone-related disease such as endometriosis. The Second part is extended to elucidate associated cellular and molecular mechanisms of radioresistance and  radioresistance-associated organ specific metastatic potential among gynecological cancers (Focused on human cervical, endometrial and ovarian cancers).

Research Topics:

1. Radioresistance Study in Gynecological Cancers  2. Endometrosis Study 

Selected Publications

1.Chu CH, Chuang PC, Chen JS, Su CH, Chan YL, Yang YJ, Chiang YT, Su YY, Gean PW, Sun HS. TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior. FASEB J. 2020 Feb;34(2):3267-3288. (SCI Impact Factor: 5.391, Biology 9/93=9.7%) 
2.Chan YL, Lai WC, Chuang PC, Chen JS, Tseng JT, Jou J, Lee CT, Sun HS. TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis. Cancers (Basel). 2020 Jul 8;12(7):1844. (SCI Impact factor: 6.639; Oncology= 37/244=15%) 
3.Wang FS, Lian WS, Lee MS, Weng WT, Huang YH, Chen YS, Sun YC, Wu SL, Chuang PC#, Ko JY#. Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and -independent pathways. J Mol Med (Berl). 2017 May;95(5):499-512. (SCI Impact Factor: 6.029, Medicine, Research & Experimental 18/128=14.0%)# equal correspondent author 
4.Chuang JI, Huang JY, Chuang PC, Tsai SJ, Sun HS, Yang SH, Huang BM, Ching CH. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med. 2015 Sep 28;89:274-286. (SCI: impact factor: 7.376, Endocrino & Meta 16/143=11.1%) 
5.Ko JY, Chuang PC, Ke HJ, Chen YS, Sun YC, Wang FS. MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation. Bone. 2015 Jul 2;81:80-88. (SCI: impact factor: 4.417, Endocrinology& Metabolism 36/143=25.1%, citation=40)     
6.Lin CL, Lee PH, Hsu YC, Ko JY, Chuang PC, Huang YT, Wang SY, Wu SL, Chen YS, Chiang WC, Reiser J, Wang FS. MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. J Am Soc Nephrol. 2014 Aug;25(8):1698-709. (SCI: impact factor: 10.121, Urology& Nephrology 2/77=2.6%) 
7.Yang JL, Lin YT, Chuang PC, Bohr VA, Mattson MP. BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1. Neuromolecular Med. 2014 Mar;16(1):161-74. (SCI: impact factor: 3.885, Neurosciences, 77/252=30.6%) 
8.Wang FS*, Chuang PC*, Lin CL, Chen MW, Ke HC, Chang YH, Chen YS, Wu SL, Ko JY MicroRNA miR-29a Protects from Glucocorticoid-induced Bone Loss and Fragility by Orchestrating Bone Acquisition and Resorption. Arthritis & Rheumatism 2013 Jun;65(6):1530-40. (SCI: impact factor: 10.995, Rheumatology, 3/32=9.3 %) * Equal contribution of first -author 
9.Ko JY*, Chuang PC*, Chen MW, Ke HC, Wu SL, Chang YH, Chen YS, Wang FS. MicroRNA-29a ameliorates glucocorticoid-induced suppression of osteoblast differentiation by regulating β-catenin acetylation. Bone. 2013 Dec;57(2):468-75. (SCI: impact factor: 4.147, Endocrinology& Metabolism 36/143=25%) * Equal contribution of first -author 
10.Chuang PC, Wu MH, Lin YJ, Tsai SJ. Suppression of annexin A2 by prostaglandin E2 impairs  phagocytic ability of peritoneal macrophages in women with endometriosis. Hum Reprod. 2013 Apr;28(4):1045-53. (SCI: impact factor: 6.918, Obstetric & Gynecology 4/82=4.8%)  * Equal contribution of first -author 
11.Wu KL, Huang EY, Jhu EW, Huang YH, Chuang PC, Su WH, Yang KD. Overexpression of galectin-3 enhances migration migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway. J Gastroenterol. 2013 Mar;48(3):350-9. (SCI: impact factor: 6.132, Gastroenterology &Hepatology 14/74=18.9%) 
12.Huang EY, Chen YF, Chen YM, Lin IH, Wang CC, Su WH, Chuang PC, Yang KD. A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells. Cell Death Dis. 2013 Jan 12;3(1):e251. (SCI: impact factor:8.469; Biochem & Mol Biol 44/297=14.9%) 
13.Chuang PC, Su WH, Huang EY, Yang KD. Radiation-induced increase in cell migration and metastatic potential of cervical cancer cells operates via the K-Ras pathway.  Am J Pathol. 2012  Feb;180  (2):862-71.  (SCI; impact factor: 5.220, Pathology 7/77=9.09%)  
14.Wu MH , Lu CW, Chuang PC, Tsai S. J. Prostaglandin E2: the master of endometriosis? Experimental  Biology and Medicine (mini review). Experimental Biology and Medicine. 2010 Jun;235: 668–677. (SCI; impact factor: 2.635, Medicine, Research and Experimental 34/93=36.5%) 
15.Chuang PC, Lin YJ, Wu MH, Wing LC, Shoji Y, Tsai S. J; Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol. 2010 Feb;176(2):850-60. (SCI; impact factor: 5.220, Pathology 7/77=9.09%) 
16.Chuang PC, Wu MH, Shoji Y, Tsai SJ. Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. J Pathol. 2009 Oct;219(2):232-41. (SCI; impact factor: 7.966, Pathology, 3/75=4%) 
17.Chuang PC, Sun HS, Chen TM, Tsai SJ. Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase C delta and Elk-1 signaling. Mol Cell Biol. 2009 Nov;26(22):8281-92. (SCI; impact factor: 6.342; Biochem & Mol Biol 50/290=17.2%)  

Conference Papers and Presentations:                                                                                                                                                              1.Chuang PC. 2021 T-cell lymphoma invasion and metastasis 2S expedited endometriosis Progression. The Ninth Asian Conference on Endometriosis (ACE IV), Colombo, Sri Lanka. ( Video conference)  
2.Chuang PC. 2020 TIAM2S involving in local-to central inflammation to ameliorate endometriosis progression. The 14th World Congress on Endometriosis, Shanghai, China (Invited Speaker; Video conference) 
3.Chuang PC. 2019 11th Translational circulatory and stem cell research. KCGMH, Kaohsiung, Taiwan. (Invited Moderator)  
4.Chuang PC. 2018 Frontiers in Translational Medicine, Kaohsiung, Taiwan (Invited Moderator). 
5.Chuang PC. 2018 Mutifaced roles of TIAM2S on accelerating endometriosis progression. The Seventh Asian Conference on Endometriosis (ACE VII), Taipei, Taiwan. (Invited Speaker & Moderator) 
6.Chuang PC. 2016 Mechanistic Study of Endometriosis (Growth and Immune dysfunction) KMU, Kaohsiung, Taiwan. (Invited Speaker) 
7.Chuang PC. 2016 Employing Selective Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibitor Ameliorates Endometriosis. The Fifth Asian Conference on Endometriosis (ACE IV), Osaka, Japan (Invited Speaker & Oral Presentation Section Chairman)  
8.Chuang PC et al. 2015 Extracorporeal shock wave combined umbilical cord mesenchymal stem cell therapy attenuated skeletal muscle injury via microRNA-29a/MGC93704. Asia Pacific Summit in Shockwave Medicine, Kaohsiung, Taiwan. (Invited Speaker) 
9.Chuang PC. 2015 Targeting fibroblast growth factor 9-augmentated angiogenesis mitigates    endometriosis. Taiwan Association for Minimally Invasive Gynecology, Tainan, Taiwan (Invited  Keynote Speaker) 
10.Chuang PC. 2015 Radiation-augmented Cervical Cancer Metastasis through Galectin/K-Ras/c-Raf/p38 Pathway. 63 rd Association of University Radiologists (AUR) Annual Meeting. New Orleans, Louisana, USA. (Oral Presentation) 
11.Chuang PC. 2014 From Endometriosis Study to Cancer Stem Cell Study. Chia-Yi Chang-Gung Memorial Hospital, Taiwan (Invited Speaker)  
12.Chuang PC. 2014 Targeting prostaglandin E2/fibroblast growth factor 9-augmentated angiogenesis mitigates endometriosis. The Second Asian Conference on Endometriosis (ACE III), Seoul, Korea (Invited Keynote Speaker) 
13.Chuang PC, 2014 Mechanistic Studies of miRNAs in Endometrial and Cervical Cancer Stem Cells.  Frontiers in Translational Medicine, Kaohsiung, Taiwan (Invited Speaker)  
14.Chuang PC, 2013 Mechanistic Studies of miRNAs contribute to ovarian and cervical Cancer stem cells. The Society for the Study of Reproduction. Montréal, Québec, Canada (Invited Oral Presentation) 
15.Chuang PC. 2013 Pleiotropic Effects of Prostaglandin E2 Contribute to The Development of Endometriosis. Frontiers in Translational Medicine, Kaohsiung, Taiwan (Invited Speaker) 
16.Chuang PC. 2013 The role of peritoneal macrophages in pathogenesis of endometriosis.  The Second Asian Conference on Endometriosis (ACE II), Tainan, Taiwan. (Invited Speaker)  
17. Chuang PC 2013 Regulation of fibroblast growth factor-9 and Annexin-2 by aberrant production of prostaglandin in human endometrial cancers. 2013 Symposium on Recent Advances in Stem Cells.  (Invited Oral Presentation)
18.Chuang PC. 2012 Radiation-induced increase in cell migration and metastatic potential of cervical  cancer cells operates via the K-Ras pathway. Taiwan-Hong Kong Physiology Symposium. Hong Kong. (Invited Young Scientists Oral Presentation) 
19.Chuang PC. 2011 Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to  the development of endometriosis. 7th FAOPS Congress. Taipei, Taiwan. (Invited Oral Presentation in section OR3-02-03) 
20.Chuang PC. 2011 Immunosuppressive roles of prostaglandin E2 contributes to the development of endometriosis. Taiwan-Hong Kong Physiology Symposium, Chia-Yi, Taiwan. (Invited Oral Presentation)  
21.Chuang PC. 2010 Prostaglandin E2 inhibits phagocytosis of macrophages via downregulation of CD36 in endometriosis. The First Asian Conference on Endometriosis (ACE I), Shanghai, China.   (Invited Oral Presentation)  

放射腫瘤科
黃英彥醫師
一般外科
謝青華醫師
血液腫瘤科
陳彥豪醫師
蘇祐立醫師

高雄長庚智慧醫療產學聯盟計畫研究團隊

Education 

1998/09-2020/06 M.S.  Department of Physiology, Medical College, National Cheng Kung University, Tainan, Taiwan 
2002/09-2006/12 Ph.D. The Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan 
 
Professional Experience
2007/01-2009/01 Postdoctoral Fellow, Department of Physiology, National Cheng Kung University, Tainan, Taiwan                                                     
2009/02-2012/07 Assistant Research Fellow, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan 
2012/08-2021/07 Associate Research Fellow, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan 
2021/08-present  Research Fellow, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Academic Appointment: 
2012/09- present Biosafety Committee Member of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2015/02--present Reviewer of National Science and Technology Council Research Fund, Taiwan
2015/09- present Committee Member of the Institute of Basic Medical Sciences PhD Program and the International Doctoral Degree Program, Medical College, National Cheng Kung University, Tainan, Taiwan
2018/08-present Associate Professor (joint appointment), Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
2020-present Committee Member of the Chang Gung Medical Research Fund, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Honors and Awards:
2006 Award of Excellence in Ph.D. Dissertation, The institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan    
2006 Second Place Award Winner in International Symposium on Cell Signaling and Gene Regulation, Taipei, Taiwan 
2007 First Place Award Winner in Reward of 15th Symposium on Recent Advances in Cellular and Molecular Biology; Dr. Chieh-Tein Hsu’s Award Presentation, Taipei, Taiwan  
2012 Award of  Distinguished Young Scientists Oral Presentation Taiwan-Hong Kong Physiology Symposium, Hong Kong
2015 Award of  Best Oral Presentation in 63 rd Association of University Radiologists  Annual Meeting. New Orleans, Louisana, USA 
2021 Award of  Best Oral Presentation in the 9th Asian Conference on Endometriosis (ACE IV), Colombo, Sri Lanka (Video Conference)
2022 Outstanding Young Alumni Award of the 90th National Cheng Kung University, Tainan, Taiwan