33. Kuan-Chih Chung, Kuen-Lin Wu, Yu-Li Su, Kung-Chuan Cheng, Chien-En Tang, Ling-Chiao Song, Hong-Hwa Chen, Ko-Chao Lee* Outcomes of robot-assisted versus laparoscopic surgery for colorectal cancer in adults > 75 years old: a propensity score matched analysis of the US Nationwide Inpatient Sample. Dis Colon Rectum. 2024 Sep 1;67(9):1121-1130. doi: 10.1097 / DCR.
32. Ko-Chao Lee, Kuan-Chih Chung*, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song. Potential beneficial effects of long-term aspirin use on the prevalence of colorectal cancer: a population-based study of the US Nationwide Inpatient Sample. Cancer Causes Control. 2024 Mar;35(3):477-486. doi: 10.1007/s10552-023-01803-x. Epub 2023 Oct 19
31. Sin-Ei, Juang, Kuan-Chih Chung, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song, Chien-En Tang, Hong-Hwa Chen, Ko-Chao Lee* Outcomes of robot-assisted versus laparoscopic surgery for colorectal cancer in morbidly obese patients: a propensity score-matched analysis of the U.S. Nationwide Inpatient Sample. J Gastroenterol Hepatol. 2023 Sep;38(9):1510-1519. doi: 10.1111/jgh.16212. Epub 2023 May 16.
30. Ko-Chao Lee, Hong-Hwa Chen, Kung-Chuan Cheng, Ting-Ting Liu, Kam-Fai Lee, Chih-Chuan Teng, Cheng-Yi Huang, Meng-Chiao Hsieh, Hsing-Chun Kuo* Use of iTRAQ-based quantitative proteomic identification of Chromogranin-A and Ubiquitin carboxyl-terminal hydrolase isozyme L1 correlated with lymph node metastasis in colorectal carcinoma J Cell Mol Med. 2023
29. Chien-En Tang, Kung-Chuan Chen, Kuen-Lin Wu, Hong-Hwa Chen, Ko-Chao Lee* Radiofrequency ablation in treatment of chronic radiation proctitis: Clinical experience and long-term follow-up. Life (Basel). 2023, Feb 17 ;13(2):566 doi:10.3390/life13020566
28. Kuan-Chih Chung, Sin-Ei, Juang , Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song, Ko-Chao Lee* Association between metabolic syndrome and colorectal cancer incidence and all-cause mortality: a hospital-based observational study BMC Gastroenterol. 2022 Nov 11;22(1):453. doi: 10.1186/s12876-022-02505-5
27. Ko-Chao Lee, Kuen-Lin Wu, Shun-Fu Chang, Hsin-I Chang , Cheng-Nan Chen*, Yih-Yuan Chen* Fermented ginger extract in natural deep eutectic solvent enhances cytotoxicity by inhibiting NF-kB mediated CXC chemokine receptor 4 expression in oxaliplatin-resistant human colorectal cancer cells Antioxidants (basel). 2022 Oct 19;11(10):2057. doi: 10.3390/antiox11102057
26. Ling-Chiao Song, Kung-Chuan Cheng, Kuen-Lin Wu, Hong-Hwa Chen, Ko-Chao Lee* Risk factors of delayed hemorrhage after LigaSure hemorrhoidectomy BMC Surg. 2022 Oct 13;22(1):361. doi: 10.1186/s12893-022-01802-w.
25. Ko-Chao Lee, Kuen-Lin Wu, Chia-Kung Yen, Shun-Fu Chang, Cheng-Nan
Chen *, Ying-Chen Lu * Inhibition of NLRP3 by Fermented Quercetin Decreases Resistin-induced Chemoresistance to 5-Fluorouracil in Human colorectal cancer Cells. Pharmaceuticals (Basel). 2022 Jun 27;15(7):798. doi: 10.3390/ph5070798
24. Ko-Chao Lee, Kuan-Chih Chung*, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song. The impact of obesity on postoperative outcomes in colorectal cancer patients: a retrospective database study. Support Care Cancer. 2022 Mar;30(3):2151-2161. doi: 10.1007/s00520-021-06626-7
23. Ko-Chao Lee, Kuen-Lin Wu, Chia-Kung Yen, Cheng-Nan Chen, Shun-Fu Chang, Wen-Shih Huang* 6-shogaol Antagonizes the Adipocyte-conditioned Medium-initiated 5-fluorouracil Resistance in Human DLD-1 Colorectal Cancer Cells through Controlling the SREBP-1 level. Life 2021, Oct 10;11(10):1067. doi:10.3390/life11101067
22. Kung-Chuan Cheng, Hsing-Chun Kuo, Meng-Chiao Hsieh, Cheng-Yi Huang, Chih-Chuan, Teng, Shui-Yi Tung, Chien-Heng Shen, Kam-Fai Lee, Ya-Ling Yang, Ko-Chao Lee*. Identification of two novel CIL-102-targeing proteins, ERP29 and FUMH, to inhibit the migration and invasiveness of colorectal cancer cells by using the proteomic approach. Biomolecules 2021, Aug 27;11(9):1280. doi:10.3390 /biom11091280
21. Kuan-Chih Chung, Ko-Chao Lee*, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song. Path analysis of the impact of obesity on postoperative outcomes in colorectal cancer patients: a population-based study. J. Clin. Med. 2021 Jun 29;10(13):2904. doi:10.3390/jcm10132904
20. Kuan-Chih Chung, Ko-Chao Lee*, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song. Differential short-term outcomes of laparoscopic resection in colon and rectal cancer patients aged 80 and older: an analysis of Nationwide Inpatient Sample. Surg Endosc. 2021 Feb;35(2):872-883. doi: 10.1007/s00464-020-07459-x. Epub 2020 Feb 18
19. Ko-Chao Lee, Chia-Kung Yen, Cheng-Nan Chen, Shun-Fu Chang, Ying-Chen Lu*, Wen-Shih Huang*. Drug Resistance of CPT-11 in Human DLD-1 Colorectal Cancer Cells through MutS 2 Homolog 2 Upregulation. Int J Med Sci. 2021 Jan 16;18(5):1269-1276. doi: 10.7150/ijms.52620. eCollection 2021
18. Ko-Chao Lee, Kuan-Chih Chung*, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao, Song, Wan-Hsiang Hu. The impact of comorbid diabetes on short-term postoperative outcomes in stage I/II colon cancer patients undergoing open colectomy. Biomed Res Int. 2020 Aug 4;2020:2716395. doi: 10.1155/2020/2716395. eCollection 2020.
17. Kung-Chuan Cheng , Sheung-Fat Ko , Ko-Chao Lee* Colonic duplication presenting as a huge abdominal mass in an adult female. Int J Colorectal Dis. 2019 Nov;34(11):1995-1998. doi: 10.1007/s00384-019-03409-9. Epub 2019 Oct 23
16. Ko-Chao Lee, Kam-Fai Lee, Chien-Heng Shen, Wen-Shih Huang, Chien-Chang Lu, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chih-Chuan Teng, Shui-Yi Tung, Meng-Chiao Hsieh, Hsing-Chun Kuo*. Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNF and Fas/Fas ligand via the JNK signaling pathway with the implications of p300-mediated histone acetylation. Front Pharmacol. 2019 Oct 15;10:1174. doi: 10.3389/fphar.2019.01174. eCollection 2019.
15. Ko-Chao Lee, Chia-Cheng Liu, Wan-Hsiang Hu, Chien-Chang Lu, Shung-Eing Lin, Hong-Hwa Chen*. Risk of delayed bleeding after hemorrhoidectomy. Int J Colorectal Dis. 2019 Feb;34(2):247-253. doi: 10.1007/s00384-018-3176-6. Epub 2018 Oct 24
14. Wen-Shih Huang, Chien-Tsong Lin, Cheng-Nan Chen, Shun-Fu Chang, Hsin-i Chang, Jing-Lan Liu, Ko-Chao Lee*. Metformin Increases the Cytotoxicity of Oxaliplatin in Human DLD-1 Colorectal Cancer Cells through Down-regulating HMGB1 Expression. J Cell Biochem. 2018 Aug;119(8):6943-6952.doi: 10.1002/jcb.26898. Epub 2018 May 8.
13. Ko-Chao Lee*, Kuan-Chih Chung, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Chien-Chang Lu. Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study. BMJ Open. 2018 Jul 17;8(7):e020511. doi: 10.1136/bmjopen-2017-020511.
12. Ko-Chao Lee, Chih-Chuan Teng, Chien-Heng Shen, Wen-Shih Huang, Chien-Chang Lu, Hsing-Chun Kuo, Shui-Yi Tung*. Protective effect of black garlic extracts on tert-Butyl hydroperoxide-induced injury in hepatocytes via a c-Jun N-terminal kinase-dependent mechanism. Exp Ther Med. 2018 Mar; 15(3) :2468-2474. doi: 10.3892/etm.2018. 5719. Epub 2018 Jan 8.
11. Ko-Chao Lee, Kuan-Chih Chung*, Hong-Hwa Chen, Chia-Cheng Liu, Chien-Chang Lu. Prognostic factors of overall survival and cancer-specific survival in patients with resected early stage rectal adenocarcinoma: a SEER-based study. J Investig Med. 2017. Dec;65(8):1148-1154. doi: 10.1136/jim-2017-000496
10. Ko-Chao Lee, Chien-Tsong Lin, Shun-Fu Chang, Cheng-Nan Chen,
Jing-Lan Liu, Wen-Shih Huang*. Effect of AICAR and 5-Fluorouracil on X-ray Repair Cross Complementing Group 1 Expression and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells. Int J Mol Sci. 2017. 18(11), 2363; doi:10.3390/ijms18112363
9. Kuen-Lin Wu, Ko-Chao Lee*, Chia-Cheng Liu, Hong-Hwa Chen, Chien-Chang Lu. Laparoscopic versus open surgery for diverticulitis: a systematic review and meta-analysis. Dig Surg 2017; 34(3) :203-215
8. Ko-Chao Lee, Hsing-Chun Kuo, Chien-Heng Shen, Chien-Chang Lu, Wen-Shih Huang, Meng-Chiao Hsieh, Cheng-Yi Huang, Yi-Hung Kuo, Kam-Fai Lee, Chih-Chuan Teng, Li-Ya Lee, Shui-Yi Tung*. A proteomics approach to identifying novel protein targets involved in erinacine A mediated inhibition of colorectal cancer cells aggressiveness. J Cell Mol Med. 2017 Mar ;21(3): 588-599. doi: 10.1111/jcmm.13004.
7. Ko-Chao Lee, Hao Lin, Chan-Chao ChangChien, Hung-Chun Fu, Ching-Chou Tsai, Chen-Hsuan Wu, Yu-Che Ou*. Difficulty in diagnosis and different prognosis between colorectal cancer with ovarian metastasis and advanced ovarian cancer: An empirical study of different surgical adoptions. Taiwan J Obstet Gynecol. 2017 Feb;56(1):62-67.
6. Ko-Chao Lee*, Yu-Che Ou , Wan-Hsiang Hu, Chia-Cheng Liu, Hong-Hwa Chen*. Meta-analysis of outcomes of patients with stage IV colorectal cancer managed with chemotherapy/radiochemotherapy with and without primary tumor resection. Onco Targets Ther. 2016 Nov 15;9: 7059–7069
5. Wen-Shih Huang, Meng-Chiao Hsieh, Cheng-Yi Huang , Yi-Hung Kuo, Shui-Yi Tung, Chien-Heng Shen, Yung-Yu Hsieh, Chih-Chuan Teng, Kam-Fai Lee, Te-Chuan Chen, Ko-Chao Lee*, Hsing-Chun Kuo*. The Association of CXC Receptor 4 mediated signaling pathway with oxaliplatin-resistant human colorectal cancer cells. PLoS One. 2016 Sep 26;11(9):e0159927. doi: 10.1371/ journal. pone.0159927. eCollection 2016
4. Wen-Shih Huang , Jen-Tsung Yang , Chien-Chang Lu, Shun-Fu Chang, Cheng-Nan Chen, Yu-Ping Su, Ko-Chao Lee*. Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells. Int. J. Mol. Sci. 2015 Dec 9; 16(12): 29370–29382.
3. Ko-Chao Lee, Chien-Chang Lu*, Shung-Eing Lin, Chia-Lo Chang, Hong-Hwa Chen. Infiltration of local anesthesia at wound site after single-incision laparoscopic colectomy reduces postoperative pain and analgesic usage. Hepatogastroenterology. 2015 Jun;62(140):811-6.
2. Ko-Chao Lee, Chien-Chang Lu, Wang-Hseng Hu, Shung-Eing Lin, Hong-Hwa Chen*. Colonoscopic diagnosis of amebiasis: A case series and systematic review. Int J Colorectal Dis. 2015 Jan;30(1): 31-41.
1. Ko-Chao Lee, Hong-Hwa Chen, Kuan-Chih Chung, Wang-Hseng Hu, Chia-Lo Chang, Shung-Eing Lin, Kai-Lung Tsai, Chien-Chang Lu*. Meta-analysis of randomized controlled trials comparing outcomes for stapled hemorrhoidopexy versus LigaSure hemorrhoidectomy for symptomatic hemorrhoids in adults. Int J Surg. 2013; 11(9):914-8.
