研究成果(2017~2024)

Zong-Sheng Wu, Wei-Chia Lee, Michael B Chancellor, Hung-Jen Wang, Chao-Cheng Huang, Yao-Chi Chuang. Extracorporeal shock wave therapy modulates miRNA expression, reduces inflammation, and improves liposome retention in a rat model of cyclophosphamide induced cystitis-experimental studies. Int J Surg. 2024 Jul 22;110(11):6869-6872. doi: 10.1097/JS9.0000000000001961.

Wen-Yi Chou, Kuan-Ting Wu, Po-Cheng Chen, Shun-Wun Jhan, Chia-Feng Wu, Jai-Hong Cheng. Clinical, sonographic and molecular changes in calcific tendinitis of the shoulder following extracorporeal shockwave therapy: a prospective case-control study. Int J Surg. 2024 Sep 6. doi: 10.1097/JS9.0000000000002078.

Hsu, Chieh-Cheng; Wu, Kay LH; Peng, Jei-Ming; Wu, Yi-No; Chen, Hou-Tsung; Lee, Meng-Shiou; Cheng, Jai-Hong. Low-Energy extracorporeal shockwave therapy improves locomotor functions, tissue regeneration and modulating the inflammation induced FGF1 and FGF2 signaling to protect damaged tissue in spinal cord injury of rat model: An experimental animal study. Int J Surg. 2024 Oct 24. doi: 10.1097/JS9.0000000000002128.

Jih-Yang Ko, Chung-Cheng Huang, Po-Hua Huang, Jeng-Wei Chen, Chin-Yi Liao, Shu-Jui Kuo. Effects of supplementing extracorporeal shockwave therapy (ESWT) to hyaluronic acid (HA) injection among patients with rotator cuff lesions without complete tear: A prospective double-blinded randomized study. Int J Surg. 2024 Aug 22. doi:10.1097/JS9.0000000000002063.

Jai-Hong Cheng, Shun-Wun Jhan, Po-Cheng Chen, Shan-Ling Hsu, Ching-Jen Wang, Daniel Moya, Yi-No Wu, Chien-Yiu Huang, Wen-Yi Chou, Kuan-Ting Wu. Enhancement of hyaline cartilage and subchondral bone regeneration in a rat osteochondral defect model through focused extracorporeal shockwave therapy modulation of transforming growth factor-beta and bone morphogenetic proteins-2, -3, -4, -5, and -7 expression. Bone Joint Res. 2024 Jul 9;13(7):342-352. doi: 10.1302/2046-3758.137.BJR-2023-0264.R2

Kuan-Ting Wu, Jai-Hong Cheng, Shun-Wun Jhan, Po-Cheng Chen, Ching-Jen Wang, Wen-Yi Chou. Prognostic factors of extracorporeal shockwave therapy in the treatment of nonunion in long bones: a retrospective study. Int J Surg . 2024 Jun 24. doi: 10.1097/JS9.0000000000001848. Online ahead of print.

Yin-Hua Cheng, Ching-Wei Huang, Hao-Ting Lien, Yu-Yang Hsiao, Pei-Ling Weng, Yung-Chiao Chang, Jai-Hong Cheng, Kuo-Chung Lan. A Preliminary Investigation of the Roles of Endometrial Cells in Endometriosis Development via In Vitro and In Vivo Analyses. Int J Mol Sci. 2024 Mar 30;25(7):3873. doi: 10.3390/ijms25073873.

Wen-Yi Chou, Jai-Hong Cheng, Yu-Jui Lien, Tian-Hsiang Huang, Wen-Hsien Ho, Paul Pei-Hsi Chou. Treatment Algorithm for the Resorption of Calcific Tendinitis Using Extracorporeal Shockwave Therapy: A Data Mining Study. Orthop J Sports Med . 2024 Mar 5;12(3):23259671241231609. doi: 10.1177/23259671241231609. eCollection 2024 Mar.

Shan-Ling Hsu, Shun-Wun Jhan, Chieh-Cheng Hsu, Yi-No Wu, Kay L H Wu, Chun-En Aurea Kuo, Hung-Wen Chiu, Jai-Hong Cheng. Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head. Biomed J. 2023 Dec;46(6):100571. doi: 10.1016/j.bj.2022.11.004. Epub 2022 Nov 26.

Wu ZS, Luo HL, Chuang YC, Lee WC, Wang HJ, Chancellor MB. Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway. Biomedicines. 2023 Mar 17;11(3):935.

Lin KC, Fang WF, Sung PH, Huang KT, Chiang JY, Chen YL, Huang CR, Li YC, Lee MS, Yip HK. Early and Dose-Dependent Xenogeneic Mesenchymal Stem Cell Therapy Improved Outcomes in Acute Respiratory Distress Syndrome Rodent Through Ameliorating Inflammation, Oxidative Stress, and Immune Reaction. Cell Transplant. 2023 Jan-Dec;32:9636897231190178.

Yang CC, Chuang FC, Chang CL, Huang CR, Chen HH, Yip HK, Chen YT. Melatonin-Assisted Cisplatin Suppresses Urinary Bladder Cancer Cell Proliferation and Growth through Inhibiting PrPC-Regulated Cell Stress and Cell Proliferation Signaling. Int J Mol Sci. 2023 Feb 8;24(4):3353.

Yang CC, Chen YL, Sung PH, Chiang JY, Chen CH, Li YC, Yip HK. Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat. Biomed J. 2023 Jun 22:100613.

Shan-Ling Hsu,a,b Shun-Wun Jhan,a,b Chieh-Cheng Hsu,a,b Yi-No Wu,c Kay L.H. Wu,d Chun-En Aurea Kuo,e,g Hung-Wen Chiu,a,f and Jai-Hong Cheng. Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral. Biomed J. 2023 Dec; 46(6): 100571.

Shen YC, Chen CH, Chancellor MB, Chuang YC*. Prospective, Randomized, Double-blind, Placebo-controlled, Pilot Study of Extracorporeal Shock Wave Therapy for Detrusor Underactivity/Underactive Bladder. Eur Urol Focus . 2023 May;9(3):524-530. doi: 10.1016/j.euf.2022.11.011.

Wu ZS, Wang HJ, Lee WC, Luo HL, Lin TK, Chuang YC*. Low-Energy Shock Wave Suppresses Prostatic Pain and Inflammation by Modulating Mitochondrial Dynamics Regulators on a Carrageenan-Induced Prostatitis Model in Rats. Int J Mol Sci . 2023 Feb 15;24(4):3898. doi: 10.3390/ijms24043898.

Chen PY, Cheng JH, Wu ZS, Chuang YC. New Frontiers of Extracorporeal Shock Wave Medicine in Urology from Bench to Clinical Studies. Biomedicines. 2022 Mar 15;10(3):675. doi: 10.3390/biomedicines10030675.

Lo WS, Sheen JM, Chen YC, Wu KT, Wang LY, Lau YC, Hsiao CC, Ko JY. The Application of Focused Medium-Energy Extracorporeal Shockwave Therapy in Hemophilic A Arthropathy. Healthcare (Basel). 2022 Feb 11;10(2):352. doi: 10.3390/healthcare10020352.

Sung PH, Yin TC, Chai HT, Chiang JY, Chen CH, Huang CR, Yip HK. Extracorporeal Shock Wave Therapy Salvages Critical Limb Ischemia in B6 Mice through Upregulating Cell Proliferation Signaling and Angiogenesis. Biomedicines. 2022 Jan 6;10(1):117. doi: 10.3390/biomedicines10010117.

Wang HJ, Su CH, Chen YM, Yu CC, Chuang YC. Molecular Effects of Low-Intensity Shock Wave Therapy on L6 Dorsal Root Ganglion/Spinal Cord and Blood Oxygenation Level-Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Changes in Capsaicin-Induced Prostatitis Rat Models. Int J Mol Sci. 2022 Apr 25;23(9):4716. doi: 10.3390/ijms23094716.

Jhan SW, Wang CJ, Wu KT, Siu KK, Ko JY, Huang WC, Chou WY, Cheng JH. Comparison of Extracorporeal Shockwave Therapy with Non-Steroid Anti-Inflammatory Drugs and Intra-Articular Hyaluronic Acid Injection for Early Osteoarthritis of the Knees. Biomedicines. 2022 Jan 18;10(2):202. doi: 10.3390/biomedicines10020202.

Cheng JH, Chou WY, Wang CJ, Siu KK, Peng JM, Wu YN, Lee MS, Huang CY, Ko JY, Jhan SW . Pathological, Morphometric and Correlation Analysis of the Modified Mankin Score, Tidemark Roughness and Calcified Cartilage Thickness in Rat Knee Osteoarthritis after Extracorporeal Shockwave Therapy. Int J Med Sci. 2022 Jan 1;19(2):242-256. doi: 10.7150/ijms.67741. eCollection 2022.

Wang HJ, Tyagi P, Lin TK, Huang CC, Lee WC, Chancellor MB, Chuang YC. Low Energy Shock Wave Therapy Attenuates Mitochondrial Dysfunction and Improves Bladder Function in HCl induced Cystitis in Rats. Biomed J. 2021 Jul 2:S2319-4170(21)00072-X; https://doi.org/10.1016/j.bj.2021.06.006.

Shen YC, Tyagi P, Lee WC, Chancellor M, Chuang YC. Improves symptoms and urinary biomarkers in refractory interstitial cystitis/bladder pain syndrome patients randomized to extracorporeal shock wave therapy versus placebo. Sci Rep. 2021 Apr 6;11(1):7558. doi: 10.1038/s41598-021-87040-1.

Luo HL, Liu HY, Chang YL, Su YL, Huang CC, Lin XJ, Chuang YC. Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model. Cancers. 2021; 13(18):4558.

Cheng JH, Yen KT, Chou WY, Jhan SW, Hsu SL, Ko JY, Wang CJ, Kuo CA, Wu SY, Hsu TC, Hsu CC. Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint. Pharmaceuticals (Basel). 2021 Apr 1;14(4):318. doi: 10.3390/ph14040318.

Cheng JH, Jhan SW, Hsu CC, Chiu HW, Hsu SL. Extracorporeal Shockwave Therapy Modulates the Expressions of Proinflammatory Cytokines IL33 and IL17A, and Their Receptors ST2 and IL17RA, within the Articular Cartilage in Early Avascular Necrosis of the Femoral Head in a Rat Model. Mediators Inflamm. 2021 Jul 9;2021:9915877. doi: 10.1155/2021/9915877.

JH Cheng, CC Hsu, SL Hsu, WY Chou, YN Wu, CE Aurea Kuo, TC Hsu, LY Shiu, SW Jhan. Adipose-Derived Mesenchymal Stem Cells-Conditioned Medium Modulates the Expression of Inflammation Induced Bone Morphogenetic Protein-2, -5 and -6 as Well as Compared with Shockwave Therapy on Rat Knee Osteoarthritis. Biomedicines 2021, 9(10), 1399; https://doi.org/10.3390/biomedicines9101399.

Chang CL, Chen KH, Sung PH, Chiang JY, Huang CR, Chen HH, Yip HK. Combined high energy of extracorporeal shock wave and 5-FU effectively suppressed the proliferation and growth of tongue squamous cell carcinoma. Biomed Pharmacother. 2021 Oct;142:112036. doi: 10.1016/j.biopha.2021.112036.

PH Sung, Mel S. Lee, HT Chai, John Y. Chiang, YC Li, YC Chu, CR Huang, HK Yip. Extracorporeal Shock Wave Enhanced Exogenous Mitochondria into Adipose-Derived Mesenchymal Stem Cells and Further Preserved Heart Function in Rat Dilated Cardiomyopathy. Biomedicines 2021, 9(10), 1362; https://doi.org/10.3390/biomedicines9101362.

YT Chen, KH Huang, John Y. Chiang, PH Sung, CR Huang, YC Chu, FC Chuang, HK Yip. Extracorporeal Shock Wave Therapy Protected the Functional and Architectural Integrity of Rodent Urinary Bladder against Ketamine-Induced Damage. Biomedicines 2021, 9(10), 1391; https://doi.org/10.3390/biomedicines9101391.

Hsiao CC, Hou YS, Liu YH, Ko JY, Lee CT. Combined Melatonin and Extracorporeal Shock Wave Therapy Enhances Podocyte Protection and Ameliorates Kidney Function in a Diabetic Nephropathy Rat Model. Antioxidants (Basel). 2021 May 6;10(5):733; https://doi.org/10.3390/antiox10050733.

Chen YT, Yang CC, Sung PH, Lin KC, Chiang JY, Huang CR, Huang KH, Chuang FC, Chu YC, Huang EY, Yip HK. Long-term effect of extracorporeal shock wave therapy on attenuating radiation-induced chronic cystitis in rat. Am J Transl Res. 2020 Mar 15;12(3):999-1015.

Hsu CC, Cheng JH, Wang CJ, Ko JY, Hsu SL, Hsu TC. Shockwave Therapy Combined with Autologous Adipose-Derived Mesenchymal Stem Cells Is Better than with Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells on Knee Osteoarthritis. Int J Mol Sci. 2020 Feb 12;21(4):1217.

SL Hsu, WY Chou, CC Hsu, JY Ko, SW Jhan, CJ Wang, MS Lee, TC Hsu, JH Cheng. Shockwave Therapy Modulates the Expression of BMP2 for Prevention of Bone and Cartilage Loss in the Lower Limbs of Postmenopausal Osteoporosis Rat Model. Biomedicines 2020, 8(12), 614.

JJ Sheu, PH Sung, Christopher Glenn Wallace, CC Yang, KH Chen, PL Shao, YC Chu, CR Huang, YL Chen, SF Ko, Mel S Lee, HK Yip. Intravenous administration of iPS-MSC SPIONs mobilized into CKD parenchyma and effectively preserved residual renal function in CKD rat. J Cell Mol Med. 2020 Mar;24(6):3593-3610.

PH Sung, HJ Chiang, YC Li, John Y Chiang, CH Chu, PL Shao, FY Lee , Mel S Lee, HK Yip. Baseline factors identified for the prediction of good responders in patients with end-stage diffuse coronary artery disease undergoing intracoronary CD34+ cell therapy. Stem Cell Res Ther. 2020 Jul 29;11(1):324. doi: 10.1186/s13287-020-01835-z.

HK Yip, WF Fang, YC Li, FY Lee, CH Lee, SN Pei, MC Ma, KH Chen, PH Sung, Mel S Lee. Human Umbilical Cord-Derived Mesenchymal Stem Cells for Acute Respiratory Distress Syndrome. Crit Care Med. 2020 May;48(5):e391-e399.

Chuang YC, Meng E, Chancellor M, Kuo HC. Pain reduction realized with extracorporeal shock wave therapy for the treatment of symptoms associated with interstitial cystitis/bladder pain syndrome-A prospective, multicenter, randomized, double-blind, placebo-controlled study. Neurourol Urodyn. 2020 Jun;39(5):1505-1514.

JY Ko, KK Siu, FS Wang, CJ Wang, WY Chou, CC Huang, SJ Kuo. The Therapeutic Effects of Extracorporeal Shock Wave Therapy (ESWT) on the Rotator Cuff Lesions with Shoulder Stiffness: A Prospective Randomized Study. Biomed Res Int. Volume 2020 |Article ID 6501714.

Wu KT, Chou WY, Wang CJ, Chen CY, Ko JY, Chen PC, Cheng JH, Yang YJ. Efficacy of Extracorporeal Shockwave Therapy on Calcified and Noncalcified Shoulder Tendinosis: A Propensity Score Matched Analysis. Biomed Res Int. 2019 Mar 14;2019:2958251.

Chou WY, Wang CJ, Cheng JH, Chen JH, Chen CC, Kuo YR. Extended Extracorporeal Shockwave Therapy for Chronic Diabetic Foot Ulcers: A Case Series. Wounds. 2019 May;31(5):132-136.

Cheng JH, Wang CJ, Chou WY, Hsu SL, Chen JH, Hsu TC. Comparison efficacy of ESWT and Wharton‘s jelly mesenchymal stem cell in early osteoarthritis of rat knee. Am J Transl Res. 2019 Feb 15;11(2):586-598.

Chou WY, Cheng JH, Wang CJ, Hsu SL, Chen JH, Huang CY. Shockwave Targeting on Subchondral Bone Is More Suitable than Articular Cartilage for Knee Osteoarthritis. Int J Med Sci. 2019 Jan 1;16(1):156-166.

Chen RF, Chang CH, Wang CT, Yang MY, Wang CJ, Kuo YR. Modulation of vascular endothelial growth factor and mitogen-activated protein kinase-related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing. Wound Repair Regen. 2019 Jan;27(1):69-79.

Yang CH, Yip HK, Chen HF, Yin TC, Chiang JY, Sung PH, Lin KC, Tsou YH, Chen YL, Li YC, Huang TH, Huang CR, Luo CW, Chen KH. Long-term Therapeutic Effects of Extracorporeal Shock Wave-Assisted Melatonin Therapy on Mononeuropathic Pain in Rats. Neurochem Res. 2019 Apr;44(4):796-810.

Sung PH, Chen KH, Li YC, Chiang JY, Lee MS, Yip HK. Sitagliptin and shock wave-supported peripheral blood derived endothelial progenitor cell therapy effectively preserves residual renal function in chronic kidney disease in rat-role of dipeptidyl peptidase 4 inhibition. Biomed Pharmacother. 2019 Mar;111:1088-1102.

Chen KH, Hsiao HY, Glenn Wallace C, Lin KC, Li YC, Huang TH, Huang CR, Chen YL, Luo CW, Lee FY, Yip HK. Combined Adipose-Derived Mesenchymal Stem Cells and Low-Energy Extracorporeal Shock Wave Therapy Protect the Brain From Brain Death-Induced Injury in Rat. J Neuropathol Exp Neurol. 2019 Jan 1;78(1):65-77.

Yin TC, Sung PH, Chen KH, Li YC, Luo CW, Huang CR, Sheu JJ, Chiang JY, Lee MS, Yip HK. Extracorporeal shock wave-assisted adipose-derived fresh stromal vascular fraction restores the blood flow of critical limb ischemia in rat. Vascul Pharmacol. 2019 Feb;113:57-69.

Chuang YC, Tyagi P, Luo HL, Lee WC, Wang HJ, Huang CC, Chancellor MB. Long-term functional change of cryoinjury-induced detrusor underactivity and effects of extracorporeal shock wave therapy in a rat model. Int Urol Nephrol. 2019 Apr;51(4):617-626.

Wu KL, Chiu YC, Yao CC, Tsai CE, Hu ML, Kuo CM, Tai WC, Chuah SK, Hsiao CC. Effect of extracorporeal low-energy shock wave on diabetic gastroparesis in a rat model. J Gastroenterol Hepatol. 2019 Apr;34(4):720-727.

Hsiao CC, Huang WH, Cheng KH, Lee CT. Low-Energy Extracorporeal Shock Wave Therapy Ameliorates Kidney Function in Diabetic Nephropathy. Oxid Med Cell Longev. 2019 Jul 4;2019:8259645.

Wang CJ, Ko JY, Chou WY, Cheng JH, Kuo YR. Extracorporeal Shockwave Therapy for Treatment of Keloid Scars. Wound Repair and Regeneration 2018 Jan;26(1):69-76.

Yin TC, Wu RW, Sheu JJ, Sung PH, Chen KH, Chiang JY, Hsueh SK, Chung WJ, Lin PY, Hsu SL, Chen CC, Chen CY, Shao PL, Yip HK. Combined Therapy with Extracorporeal Shock Wave and Adipose-Derived Mesenchymal Stem Cells Remarkably Improved Acute Ischemia-Reperfusion Injury of Quadriceps Muscle. Oxid Med Cell Longev. 2018 Apr 2;2018:6012636. doi: 10.1155/2018/6012636.

Wu KL, Chiu YC, Yao CC, Tsai CE, Hu ML, Kuo CM, Tai WC, Chuah SK, Hsiao CC. Effect of extracorporeal low-energy shock wave on diabetic gastroparesis in a rat model. J Gastroenterol Hepatol. 2018 Jul 2. doi: 10.1111/jgh.14368.

Hsu SL, Cheng JH, Wang CJ, Ko JY, Hsu CH. Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1α,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee. Int J Med Sci. 2017 Sep 19;14(12):1220-1230.

Kuo SJ, Wang FS, Ko JY, Tang CH, Siu KK, Hsu YH, Tsai TC. Increased expression of type 1 cannabinoid (CB1) receptor among patients with rotator cuff lesions and shoulder stiffness. J Shoulder Elbow Surg. 2017 Nov 3. pii: S1058-2746(17)30589-X. doi: 10.1016/j.jse.2017.09.010.

Chen KH, Yang CH, Wallace CG, Lin CR, Liu CK, Yin TC, Huang TH, Chen YL, Sun CK, Yip HK. Combination therapy with extracorporeal shock wave and melaton in markedly attenuated neuropathic pain in rat. 2017 Oct 15;9(10):4593-4606.

Sheu JJ, Ali HEE, Cheng BC, Chiang HJ, Sung PH, Chen KH, Yang CC, Chen YT, Chiang JY, Lin PY, Chua S, Chai HT, Chung SY, Sun CK, Yip HK. Extracorporeal shock wave treatment attenuated left ventricular dysfunction and remodeling in mini-pig with cardiorenal syndrome. 2017 May 30;8(33):54747-54763.

Chai HT, Chen KH, Wallace CG, Chen CH, Sung PH, Chen YL, Yuen CM, Shao PL, Sun CK, Chang HW, Wang CJ, Lee MS, Yip HK, Ko SF. Extracorporeal shock wave therapy effectively protects brain against chronic cerebral hypo-perfusion-induced neuropathological changes. 2017 Nov 15;9(11):5074-5093.

Chou WY, Wang CJ, Wu KT, Yang YJ, Ko JY, Siu KK. Prognostic factors for the outcome of extracorporeal shockwave therapy for calcific tendinitis of the shoulder. 2017 Dec.; 99-B:1643–50.

Wang HJ, Cheng JH, Chuang YC. Potential applications of low-energy shock waves in functional urology. 2017 Aug;24(8):573-581. doi: 10.1111/iju.13403. Epub 2017 Jul 11. Review.

Wang HJ, Lee WC, Tyagi P, Huang CC, Chuang YC. Effects of low energy shock wave therapy on inflammatory moleculars, bladder pain, and bladder function in a rat cystitis model. 2017 Aug;36(6):1440-1447.

Wang CJ, Cheng JH, Chou WY, Hsu SL, Chen JH, Huang CY. Changes of articular cartilage and subchondral bone after extracorporeal shockwave therapy in osteoarthritis of the knee. 2017; 14: 213-223.

Wang CJ, Cheng JH, Huang CY, Hsu SL, FY Lee, HK Yip. Medial tibial subchondral bone is the key target for extracorporeal shockwave therapy in early osteoarthritis of the knee. 2017; 9(4): 1720-1731.
 

Chuang YC, Tyagi P, Wang HJ, Huang CC, Lin CC, Chancellor MB. Urodynamic and molecular characteristics of detrusor underactivity in a rat cryoinjury model and effects of low energy shock wave therapy. 2017 Aug 2. doi: 10.1002/nau.23381.