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Xevo G2-XS QTof Mass Spectrometry

LC-MS 2023.06.29
For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.

1. Maximum robustness with no compromise in performance
2. Class-leading real-world quantitative sensitivity
3. Highest quality, most comprehensive qualitative information
4. Flexibility to adapt to changing needs
5. Accessible to experts and non-experts alike

The trend for increasing complexity of both samples and studies can result in difficulty obtaining high quality data for every component of interest while maintaining optimum performance throughout the analysis.

The Xevo® G2-XS QTof combines StepWaveTM ion optics with the XS Collision Cell, providing a significant increase in sensitivity with no reduction in selectivity. During long analyses, critical hardware components stay clean for longer, so results are more reproducible and the laboratory stays productive.

Meaningful information is obtained for a greater number of components across a larger population of samples than ever before, giving a more complete picture for improved understanding and more confident decision making.

Class-leading real-world quantitative sensitivity
In targeted quantitative analysis, the greatest challenge is to detect and quantify components of interest down to the lowest possible levels, often in the presence of interferences from complex matrix. Large variation in the concentrations of different components further adds to this challenge.

The Xevo G2-XS QTof combines sensitivity and selectivity with the mass accuracy, dynamic range and speed provided by QuanTofTM technology and the enhanced quantitative capability of Tof-MRM data acquisition. The end result is class-leading quantitative performance in real everyday laboratory conditions, demonstrated by limits of detection and quantification superior to anything achieved before with high resolution MS.


Robust results you can trust with the most demanding sample matrices
The routine challenges of complex matrices are overcome by the Xevo TQ-XS which provides reproducible results injection after injection despite difficult sample matrices. In a study involving 2,000 injections of protein-precipitated plasma and analyzing sulphadimethoxine, there was little variation in peak area over the entire injection series with <3% RSD. This study aimed to reproduce the challenging conditions found in many analytical laboratories by also using a short dwell time of only 5 ms.

Tool –free probe optimization and maintenance
Redefine the way that you operate your instrument with the new atmospheric pressure ionization probes available on the Xevo TQ-XS. You don’t need to worry about time-consuming optimization steps with any tools. Even changing the probe assembly including the capillary is entirely tool-free. Ensure that you get the same results no matter who operates and maintains the instrument probes, for improved reproducibility over much longer periods of time.