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賴振宏

中華民國風濕病醫學會 理事

風濕過敏科

氣喘、過敏、紅斑性狼瘡、自體免疫疾病、類風濕性關節炎、僵直性脊椎炎、痛風關節炎

教職 : 教授

醫師網路掛號

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語言

  • 國語,英語,閩南語,客語

現職

  • 中華民國風濕病醫學會 理事
  • 林口長庚醫院 學術組 教授級 主治醫師

學歷

  • 國防醫學院醫學系
  • 美國醫師執照檢覈考試通過 (FMGEMS)
  • 美國德州醫學中心貝勒醫學院免疫學博士

經歷

  • 國防醫學院預防醫學研究所所長
  • 三軍總醫院風濕過敏免疫科主任醫師

學會與認證

  • Chinese Board of Allergy and Immunology
  • Chinese Board of Rheumatology
  • Chinese Board of Internal Medicine
  • FMGEMS (Foreign Medical Graduate Examination of Medical Science, compatible with VQE, USMLE), USA
  • National Board Qualification for Physicians

論文及期刊發表

  • Potential therapeutic targets beyond cytokines and Janus kinases for autoimmune arthritis,
  • Ferroptosis and Autoimmune Diseases.
  • Vitamin D Supplementation in Patients with Juvenile Idiopathic Arthritis.
  • Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  • (2021). Signals and Mechanisms Regulating Monocyte and Macrophage Activation in the Pathogenesis of Juvenile Idiopathic Arthritis.
  • Mitochondrial protein CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
  • Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.
  • From Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid Arthritis.
  • Epigallocatechin-3-gallate exhibits immunomodulatory effects in human primary T cells.
  • Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis.
  • Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis.
  • New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers.
  • Monosodium urate crystals induced ICAM-1 expression and cell-cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy.
  • A new laboratory surrogate (Monocyte Chemotactic Protein-1) for Disease Activity Score28: a favourable indicator for remission in rheumatoid arthritis.
  • Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions.
  • Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02.
  • Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis.
  • Pitavastatin Exerts Potent Anti-Inflammatory and Immunomodulatory Effects via the Suppression of AP-1 Signal Transduction in Human T Cells.
  • Useful message in choosing optimal biological agents for patients with autoimmune arthritis”
  • Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.
  • Liu FC, Lu JW, Chien CY, Huang HS, Lee CC, Lien SB, et al.Similarity with Quercetin.
  • Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells.
  • Operation of mitochondrial machinery in viral infection-induced immune responses.
  • Hydroxychloroquine and risk of cancer in patients with primary Sjogren syndrome: propensity score matched landmark analysis.
  • Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection.
  • JNK/AP-1 activation contributes to tetrandrine resistance in T-cell acute lymphoblastic leukaemia.
  • Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.
  • Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages.
  • Pharmacological intervention for dengue virus infection.
  • Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study.
  • A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-alpha-Stimulated Chondrocytes.
  • Gentiana scabra Reduces SR-A Expression and Oxidized-LDL Uptake in Human Macrophages.
  • Dengue virus infection induces interferon-lambda1 to facilitate cell migration.
  • Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers.
  • Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.
  • Protein kinase C isoforms in atherosclerosis: Pro- or anti-inflammatory?
  • Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory "Junn-Chenn-Zuou-SS".
  • Small-molecule inhibitors for autoimmune arthritis: success, failure and the future.
  • Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders.
  • PKCdelta signalling regulates SR-A and CD36 expression and foam cell formation.
  • Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.
  • A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells.
  • Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes: Potential Therapeutics for Osteoarthritis.
  • Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.
  • Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus.
  • A Benzamide-Linked Small Molecule HS-Cf Inhibits TNF-alpha-Induced Interferon Regulatory Factor-1 in Porcine Chondrocytes: A Potential Disease-Modifying Drug for Osteoarthritis Therapeutics.
  • Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes.
  • Immunosuppressive Effects and Mechanisms of Leflunomide in Dengue Virus Infection of Human Dendritic Cells.
  • Modulation of human T cells signaling transduction by lovastatin.
  • The modulatory mechanisms of fenofibrate on human primary T cells.
  • A/H1N1 influenza vaccination in patients with systemic lupus erythematosus: safety and immunity.
  • Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro.
  • A spontaneous intercostal artery hemorrhage in systemic lupus erythematosus.
  • Remitting seronegative symmetrical synovitis with pitting edema following acute intracranial hemorrhage.
  • Peripheral arthritis caused by Mycobacterium avium-intracellulare in a patient with ankylosing spondylitis.
  • Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus.
  • Significantly higher percentage of circulating CD27(high) plasma cells in systemic lupus erythematosus patients with infection than with disease flare-up.
  • Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes.
  • Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation.
  • Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure.
  • Suppression of tissue necrosis factor-alpha or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-1 signal transduction.
  • Acupuncture-associated Listeria monocytogenes arthritis in a patient with rheumatoid arthritis.
  • Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia.
  • Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.
  • Formation of numerous rice bodies: an unusual finding of adult-onset Still's disease.
  • Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.
  • Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway.
  • Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature.
  • Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report.
  • Usefulness of human leucocyte antigen-B27 subtypes in predicting ankylosing spondylitis: Taiwan experience.
  • Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.
  • Thymoma and hypogammaglobulinemia (Good's syndrome): a case report.
  • Taiwan experience with etanercept in juvenile rheumatoid arthritis.
  • Sweet's syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature.
  • Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes.
  • Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell.
  • Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature.
  • Immunosuppressive iridoids from the fruits of Gardenia jasminoides.
  • Carvedilol differentially regulates cytokine production from activated human peripheral blood mononuclear cells.
  • An unrecognized cause of oedema in a patient with lupus nephritis: protein losing enteropathy.
  • Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.
  • Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders.
  • Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.
  • Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1.
  • Pleural effusion as a manifestation of Lyme disease.
  • Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus.
  • Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: case report and review of the literature.
  • Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation.
  • Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus.
  • The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritis.
  • Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity.
  • Ruptured renal microaneurysms complicated with a retroperitoneal abscess for a patient with systemic lupus erythematosus.
  • Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis.
  • Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells.
  • Carvedilol modulates in-vitro granulocyte-macrophage colony-stimulating factor-induced interleukin-10 production in U937 cells and human monocytes.
  • Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium.
  • Prognostic factors and fetal outcomes of lupus pregnancy in Taiwan.
  • Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases.
  • Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction.
  • Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production.
  • Aspirin differentially regulates endotoxin-induced IL-12 and TNF-alpha production in human dendritic cells.
  • Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology.
  • Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells.
  • Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells.
  • Cell surface markers and circulating cytokines in graft versus host disease.
  • Effects of anti-rheumatic herbal medicines on cellular adhesion molecules.
  • RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.
  • Mechanisms of enhanced nuclear translocation of the transcription factors c-Rel and NF-kappa B by CD28 costimulation in human T lymphocytes.
  • CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.
  • Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.
  • Intercostal arteriovenous fistula due to pleural biopsy.
  • Intercostal arteriovenous fistula due to pleural biopsy.
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