PACTRIMS (Pan-Asian Committee for Treatment and Research in Multiple Sclerosis) 教育委員
台灣神經學學會理事
台灣神經免疫醫學會常務理事暨學術主任委員
台灣神經罕見疾病學會理事
林口長庚紀念醫院出院準備委員會主席
北區健保署醫藥審查專家
國健署罕病審查專家
學歷
倫敦帝國理工學院醫學博士 (主修幹細胞生物學)
台北醫學大學醫學系醫學士
經歷
台灣動作障礙學會秘書長
英國倫敦Hammersmith hospital 研究員
學會與認證
台灣神經學學會
台灣神經免疫醫學會
台灣神經罕見疾病學會
台灣動作障礙學會
神經科專科醫師證書
神經重症專科醫師證書
論文及期刊發表
Identification of blood metabolic biomarkers associated with diabetic distal symmetric sensorimotor polyneuropathy in patients with type 2 diabetes mellitus.
A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment.
Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.
Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease.
Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington's Disease.
Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer's Disease Treatment Strategy.
Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein.
Establishment of a new classification system for chronic inflammatory demyelinating polyneuropathy based on unsupervised machine learning.
Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis.
Isorhamnetin Attenuated the Release of Interleukin-6 from β- Amyloid-Activated Microglia and Mitigated Interleukin-6- Mediated Neurotoxicity.
Evaluating the Different Stages of Parkinson's Disease Using Electroencephalography With Holo-Hilbert Spectral Analysis.
Major Bleeding Risk in Atrial Fibrillation Patients Co-Medicated With Non-Vitamin K Oral Anticoagulants and Antipsychotics.
Biomarker of Neuroinflammation in Parkinson's Disease.
Major Bleeding Risk in Patients With Non-valvular Atrial Fibrillation Concurrently Taking Direct Oral Anticoagulants and Antidepressants.
Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson's Disease.
Altered Metabolic Profiles of the Plasma of Patients with Amyotrophic Lateral Sclerosis.
Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson's Disease.
Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against A Toxicity.
Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4- (Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2- One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer's Disease.
Assessing Plasma Levels of α-Synuclein and Neurofilament Light Chain by Different Blood Preparation Methods.
In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells?derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.�
Reaction-inhibited interfacial coating between PEDOT:PSS sensing membrane and ITO electrode for highly-reliable piezoresistive pressure sensing applications.
Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement.
Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome.
Correlations among disability, anti-AQP4 antibody status and prognosis in the spinal cord involved patients with NMOSD.
Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan.
Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation.
Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
Differences in Clinical Presentation of Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease According to Sex and Education Level.
Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.
Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
The Role of Oxidative Stress in Parkinson's Disease.
Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models.
Association of genetic variants within HLA-DR region with Parkinson's disease in Taiwan
Computed Tomography Angiography in Acute Stroke Patients Receiving Recombinant Tissue Plasminogen Activator: Outcome and Safety Evaluations in an Asian Population.
Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons.
Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
Generation of induced pluripotent stem cells from a young-onset Parkinson'sdisease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations.
Clinical and cytokine profile of adult acute necrotizing encephalopathy.
Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation.
Gulllain-Barre Syndrome After Trivalent Influenza Vaccination in Adults.
A prospective, observational study on conversion of clinically isolated syndrome to multiple sclerosis during 4-year period (MS NEO study) in Taiwan.
A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies.
Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
Association of Multiple Sclerosis with Psoriasis: A Systematic Review and Meta-Analysis of Observational Studies.
Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.
Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.
Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
Lipophilic antioxidants in neurodegenerative diseases.
Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease.
The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.
Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy.
Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy.
Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome.
The Potential of Indole/Indolylquinoline Compounds for Tau Misfolding Reduction by Enhancement of HSPB1
Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan
Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barre syndrome
Correlations of clinical, neuroimaging, and electrophysiological features in Hirayama disease
Functional properties of LRRK2 mutations in Taiwanese Parkinson's disease
Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays
Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease
Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan
The aqueous extract of Glycyrrhiza inflata can up-regulate UPR-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease
Metabolic disturbances in plasma as biomarkers for Huntington's disease
Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese
Efficacy and safety of topiramate for essential tremor: a meta-analysis of randomized controlled trials
STK39, but not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated with Han-Chinese Parkinson's disease in Taiwan
The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
The use of human amniotic fluid mesenchymal stem cells as the feeder layer to establish human embryonic stem cell lines
Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population
Wegener's granulomatosis with nervous system involvement: a hospital-based study
Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis
Genome-wide gene expression profiling of ischemia-reperfusion injury in rat kidney, intestine and skeletal muscle implicate a common involvement of MAPK signaling pathway
Plasma Inflammatory biomarkers for Huntington's disease patients and mouse model
Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients
Biomarkers for neuromyelitis optica
Effect of coexistent carpal tunnel abnormality on sensory conduction findings in polyneuropathy
The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems
Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica
Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3
Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3
Painful ophthalmoplegia with normal cranial imaging
Motor conduction findings in Fisher syndrome
Genetic variants of LRRK2 in Taiwanese Parkinson's disease
Rapid progression and brain atrophy in anti-AMPA receptor encephalitis
Sensory Conduction Study in Fisher Syndrome: Patterns of Abnormalities and Their Clinical Correlation
Association between PARK16 and Parkinson's disease in the Han-Chinese population: a meta-analysis
A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome
Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
Association between GRN rs5848 polymorphism and Parkinson’s disease in Taiwanese population
Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis
Clonal Isolation of an Intermediate Pluripotent State
Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies
Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients
Effect of pre-diabetes on future risk of stroke: meta-analysis
Features of varicella zoster virus myelitis and dependence on immune status
ATXN8-62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease
Identification of Gene Networks and Pathways Associated with Guillain-Barre Syndrome
