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張國軒 醫師

多發性硬化症與發炎性腦病變、巴金森氏病、亨丁頓氏舞蹈症、脊髓小腦萎縮症、神經退化性疾病、遺傳性神經病變、幹細胞醫學、細胞生物學

教職 : 教授

醫師網路掛號

※直接點選進入醫師網路掛號畫面※

語言

  • 國語,英語,閩南語

現職

  • 長庚大學醫學系教授
  • 林口長庚紀念醫院神經內科教授級主治醫師

學歷

  • 倫敦帝國理工學院醫學博士 (主修幹細胞生物學)
  • 台北醫學院醫學系醫學士

經歷

  • 林口長庚紀念醫院神經內科主治醫師
  • 台灣神經免疫醫學會理事
  • 台灣神經罕見疾病學會理事
  • 台灣動作障礙學會秘書長
  • 英國倫敦Hammersmith hospital 研究員

學會與認證

  • 台灣神經學學會
  • 台灣神經免疫醫學會
  • 台灣神經罕見疾病學會
  • 台灣動作障礙學會
  • 神經科專科醫師證書
  • 神經重症專科醫師證書

論文及期刊發表

  • Correlations among disability, anti-AQP4 antibody status and prognosis in the spinal cord involved patients with NMOSD.
  • Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan.
  • Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation.
  • Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
  • Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
  • Differences in Clinical Presentation of Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease According to Sex and Education Level.
  • Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.
  • Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
  • Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
  • The Role of Oxidative Stress in Parkinson's Disease.
  • Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
  • New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models.
  • Association of genetic variants within HLA-DR region with Parkinson's disease in Taiwan
  • Computed Tomography Angiography in Acute Stroke Patients Receiving Recombinant Tissue Plasminogen Activator: Outcome and Safety Evaluations in an Asian Population.
  • Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
  • Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons.
  • Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
  • Generation of induced pluripotent stem cells from a young-onset Parkinson'sdisease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations.
  • Clinical and cytokine profile of adult acute necrotizing encephalopathy.
  • Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation.
  • Gulllain-Barre Syndrome After Trivalent Influenza Vaccination in Adults.
  • A prospective, observational study on conversion of clinically isolated syndrome to multiple sclerosis during 4-year period (MS NEO study) in Taiwan.
  • Modeling Alzheimer's Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation.
  • A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies.
  • Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
  • Association of Multiple Sclerosis with Psoriasis: A Systematic Review and Meta-Analysis of Observational Studies.
  • Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
  • Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
  • Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
  • Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.
  • Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.
  • Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
  • Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
  • Lipophilic antioxidants in neurodegenerative diseases.
  • Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease.
  • The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
  • Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
  • DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.
  • Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy.
  • Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
  • Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
  • A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy.
  • Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome.
  • The Potential of Indole/Indolylquinoline Compounds for Tau Misfolding Reduction by Enhancement of HSPB1
  • Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan
  • Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barre syndrome
  • Correlations of clinical, neuroimaging, and electrophysiological features in Hirayama disease
  • Functional properties of LRRK2 mutations in Taiwanese Parkinson's disease
  • Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays
  • Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease
  • Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan
  • The aqueous extract of Glycyrrhiza inflata can up-regulate UPR-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease
  • Metabolic disturbances in plasma as biomarkers for Huntington's disease
  • Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese
  • Efficacy and safety of topiramate for essential tremor: a meta-analysis of randomized controlled trials
  • STK39, but not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated with Han-Chinese Parkinson's disease in Taiwan
  • The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
  • The use of human amniotic fluid mesenchymal stem cells as the feeder layer to establish human embryonic stem cell lines
  • Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population
  • Wegener's granulomatosis with nervous system involvement: a hospital-based study
  • Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis
  • Genome-wide gene expression profiling of ischemia-reperfusion injury in rat kidney, intestine and skeletal muscle implicate a common involvement of MAPK signaling pathway
  • Plasma Inflammatory biomarkers for Huntington's disease patients and mouse model
  • Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients
  • Biomarkers for neuromyelitis optica
  • Effect of coexistent carpal tunnel abnormality on sensory conduction findings in polyneuropathy
  • The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems
  • Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica
  • Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
  • Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3
  • Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3
  • Painful ophthalmoplegia with normal cranial imaging
  • Motor conduction findings in Fisher syndrome
  • Genetic variants of LRRK2 in Taiwanese Parkinson's disease
  • Rapid progression and brain atrophy in anti-AMPA receptor encephalitis
  • Sensory Conduction Study in Fisher Syndrome: Patterns of Abnormalities and Their Clinical Correlation
  • Association between PARK16 and Parkinson's disease in the Han-Chinese population: a meta-analysis
  • A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome
  • Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
  • Association between GRN rs5848 polymorphism and Parkinson’s disease in Taiwanese population
  • Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis
  • Clonal Isolation of an Intermediate Pluripotent State
  • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies
  • Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients
  • Effect of pre-diabetes on future risk of stroke: meta-analysis
  • Features of varicella zoster virus myelitis and dependence on immune status
  • ATXN8-62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease
  • Identification of Gene Networks and Pathways Associated with Guillain-Barre Syndrome