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張凱評 醫師

口腔癌手術、腮腺及唾液腺腫瘤治療、鼻咽癌與顱底手術治療、喉癌與下咽癌外科治療、其他頭頸部腫瘤手術

教職 : 教授

醫師網路掛號

※直接點選進入醫師網路掛號畫面※

語言

  • 國語,英語,閩南語

現職

  • 林口總院耳鼻喉部 頭頸腫瘤外科 教授級主治醫師
  • 長庚大學 醫學系 教授
  • 國際知名期刊 Head & Neck 副總編

學歷

  • 長庚大學醫學系醫學士
  • 長庚大學醫學博士
  • 美國醫師資格ECFMG證書

經歷

  • 林口總院 耳鼻喉科部 頭頸部腫瘤科科主任
  • 長庚林口總院耳鼻喉部總醫師
  • 長庚林口總院耳鼻喉部主治醫師
  • 美國德州休士頓安德生癌症中心臨床研究員

學會與認證

  • 美國耳鼻喉頭頸外科學院(AAOHNS), 美國癌症研究協會(AACR)會員
  • 台灣耳鼻喉頭頸外科 專科醫師
  • 台灣顱底外科醫學會創始會員
  • 台灣臨床腫瘤專科醫師
  • 台灣頭頸部腫瘤醫學會理事

論文及期刊發表

  • Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinom.
  • Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression.
  • Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma.
  • The Prognostic Value of Lymph Node Burden in Oral Cavity Cancer: Systematic Review and Meta-Analysis.Laryngoscope.
  • Characterization of Recurrent Relevant Genes Reveals a Novel Role of RPL36A in Radioresistant Oral Squamous Cell Carcinoma
  • Aesthetic single-stage vermilion reconstruction using facial artery musculomucosal flap and radial forearm free flap following cancer resection: A case report.
  • Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells.
  • Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma.
  • A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy.
  • High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma.
  • Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer.
  • The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma.
  • Ito R, Huang JJ, Hsieh WC, Kao HK, Lao WW, Fang KH, Huang Y, Chang YL, Cheng MH, Chang KP*. Identification of predisposing factors for osteonecrosis of the jaw after marginal mandibulectomy in the surgical management of oral squamous cell carcinoma. J Surg Oncol. 2018; 117(4): 781-787. doi: 10.1002/jso.24913 (SCI, IF=2.993; Surgery 43/197) (Correspondence Author)
  • Branchial cleft cyst: An unusual site for the cervical metastasis of nasopharyngeal carcinoma.
  • Branchial cleft cyst: An unusual site for the cervical metastasis of nasopharyngeal carcinoma.
  • Cavernous sinus involvement is not a risk factor for the primary tumor site treatment outcome of Sinonasal adenoid cystic carcinoma.
  • Third Repeat Microvascular Reconstruction in Head and Neck Cancer Patients Aged 65 Years and Older: A Longitudinal and Sequential Analysis.
  • APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.
  • Branchial cleft cyst: An unusual site for the cervical metastasis of nasopharyngeal carcinoma.
  • Multiple concomitant oral cavity cancers: Incidence, management, and outcomes.
  • Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma.
  • Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma.
  • Offodile AC 2nd, Chang KP, Chen HH, Loesch E, Hung SY, Kao HK. Feasibility and Outcomes of the Third or More Episodes of Sequential Microvascular Reconstruction for Recurrent or Second Primary Oral Cancer. Ann Surg Oncol. 2016; 23(11): 3765-72. (SCI, IF=3.655; Surgery 16/199) (Equal contribution)
  • Clinical Outcomes of Taiwanese Patients with cT4 Oral Cavity Squamous Cell Carcinoma: Toward the Identification of the Optimal Initial Treatment Approach for cT4b Patients.
  • ASC contributes to metastasis of oral cavity squamous cell carcinoma.
  • Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: a case report.
  • Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population.
  • Evaluation of Lymphatic and Vascular Invasion in Relation to Clinicopathological Factors and Treatment Outcome in Oral Cavity Squamous Cell Carcinoma.
  • Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma.
  • Low-molecular-mass secretome profiling identifies HMGA2 and MIF as prognostic biomarkers for oral cavity squamous cell carcinomas.
  • Plate exposure after anterolateral thigh free flap reconstruction in head and neck patients with composite mandibular defects.
  • Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma.
  • Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer.
  • Nasopharyngeal hemartoma.
  • Serum CXCL9 levels are associated with tumor progression and treatment outcome in patients with nasopharyngeal carcinoma.
  • Overexpression of caldesmon is associated with nodal metastasis and poorer prognosis in oral cavity squamous cell carcinomas.
  • Chang KP, Wu CC, Fang KH, Tsai CY, Chang YL, Liu SC, Kao HK*. Serum levels of chemokine (C-X-C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral cavity squamous cell carcinoma. Oral Oncol. 2013; August; 49(8): 802-807. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89) (NSC99-2314-B-182A-051-MY3)
  • Pretreatment of interleukin-6 serum levels are associated with patient survival for oral cavity squamous cell carcinoma.
  • Sphenoethmoidal inverted papilloma causing ipsilateral abducens nerve palsy.
  • The Roles of Albumin Levels in Head and Neck Cancer Patients with Liver Cirrhosis Undergoing Tumor Ablation and Microsurgical Free Tissue Transfer.
  • Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Oral Squamous Cell Carcinoma.
  • Tuberculous arthritis of the temporomandibular joint.
  • Pathology Quiz: Osteolipoma of the buccal space.
  • Prognostic significant of 18F-FDG PET parameters and plasma EBV DNA load in patients with nasopharyngeal carcinoma.
  • Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology.
  • Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis.
  • Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival.
  • Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead-based profiling.
  • Kao HK, Guo LF, Cheng MH, Chen IH, Liao CT, Fang KH, Yu JS, Chang KP*. Predicting Postoperative Morbidity and Mortality by MELD Score for Patients with Head and Neck Cancer and Liver Cirrhosis. Head Neck. 2011; April; 33(4): 529-534. (SCI, IF=2.76 ; Otorhinolaryngology 3/43) (Correspondence Author)
  • Overexpression of macrophage inflammatory protein-3alpha in oral cavity squamous cell carcinoma is associated with nodal metastasis.
  • Identification of Candidate Nasopharyngeal Carcinoma Serum Biomarkers by Cancer Cell Secretome and Tissue Transcriptome Analysis: Potential Usage of Cystatin A for Predicting Nodal Stage and Poor Prognosis.
  • Overexpression of activin A in oral squamous cell carcinoma: association with poor prognosis and tumor progression.
  • Lymphoepithelial Carcinoma of the Nasolacrimal Duct.
  • Fang KH, Kao HK, Cheng MH, Chang YL, Tsang NM, Huang YC, Lee LY, Yu JS, Hao SP, Chang KP*. Histological differentiation of primary oral squamous cell carcinomas in betel quid prevalent area. Otolaryngol Head Neck Surg. 2009; December; 141(6): 743-749. (SCI, IF=2.021; Otorhinolaryngology 11/43) (Correspondence Author)
  • Hsin LJ, Fang TJ, Chang KP*, Fang KH, Tsang NM, Chen YL, Jung SM, Yeh AR, Hao SP. Transoral Endoscopic CO2 Laser Microsurgery for Early Laryngeal Cancers. Chang Gung Med J. 2009; October; 32(5): 517-25. (Correspondence Author)
  • Chang KP, Hao SP, Chang JH, Wu CC, Tsang NM, Lee YS, Hsu CL, Ueng SH, Liau SC, Liu YL, Wei PC, Liang Y, Chang YS, Yu JS*. Macrophage Inflammatory Protein-3α Is a Novel Serum Marker for Nasopharyngeal Carcinoma Detection and Prediction of Treatment Outcomes. Clin Cancer Res. 2008; November; 14(21): 6979-6987. (SCI, IF=8.738; Oncology 12/211) (NSC94-2314-B-182A-188 & NSC96-2314-B-182A-109-MY3)
  • Fu CH, Chang KP*, Ueng SH, Wu CC, Hao SP. Primary Thyroid-Like Papillary Adenocarcinoma of the Nasopharynx. Auris Nasus Larynx. 2008; December; 35(4): 579-582. (SCI, IF=1.038;Otorhinolaryngology 30/43) (Correspondence Author)
  • Chang KP, Hsu CL, Chang YL, Tsang NM, Chen CK, Lee TJ, Huang CG, Tsao KC, Chang YS, Yu JS, Hao SP*. Complementary Serum Test of Antibodies to Epstein-Barr Virus Nuclear Antigen-1 and Early Antigen: A Possible Alternative for Primary Screening of Nasopharyngeal Carcinoma. Oral Oncol. 2008; 44:784-792. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89) (NSC92-2314-B-182A-207)
  • Fu CH, Ueng SH, Shao PY, Chang KP*. Pathology Quiz: Solitary fibrous tumor (SFT) of the submandibular gland. Arch Otolaryngol Head Neck Surg. 2008; February; 134(2): 214-216 (SCI, IF=2.327; Otorhinolaryngology 6/43) (Correspondence Author)
  • Chang KP, Hao SP, Tsang NM, Chang YL, Cheng MH, Liu CT, Lee YS, Tsai CL, Lee TJ, Wang TH, Tsai CN*. Gene Expression and Promoter Polymorphisms of DNMT3B in Nasopharyngeal Carcinomas for Taiwanese people: A Case-Control Study. Oncol Rep. 2008; January; 19: 217-222 (SCI, IF=2.486; Oncology 130/211) (NSC 95-2314-B-182A -105)
  • Chang KP, Hao SP, Chiu CT, Cheng MH, Chang YL, Lee YS, Wang TH, Tsai CN*. Promoter Polymorphisms of DNMT3B and the Risk of Head and Neck Squamous Cell Carcinoma in Taiwan: A Case-Control Study. Oral Oncol. 2007; April; 43(4): 345-351. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89)
  • Chen MF, Ueng SH, Jung SM, Chen YL, Chang KP*. A Type II First Branchial Cleft Cyst Masquerading as an Infected Parotid Warthin’s Tumor. Chang Gung Med J. 2006; August; 29(4):434-8. (Correspondence Author)
  • Cheng TY, Ueng SH, Chen YL, Chen TM, Chang KP*. Oncocytic Schineiderian Papilloma Found in a Recurrent Chronic Paranasal Sinusitis - a Case Report. Chang Gung Med J. 2006; June; 29(3):336-41. (Correspondence Author)
  • Chang KP, Hao SP, Lin SY, Ueng SH, Pai PC, Tsao KC, Tseng CK, Hseuh C, Hsiesh MS, Yu JS, Tsang NM. The 30-bp Deletion of EBV LMP-1 Gene Has No Effect in Nasopharyngeal Carcinoma. Laryngoscope. 2006; April; 116(4): 541-546. (SCI, IF=2.272; Otorhinolaryngology 9/43)(NSC92-2314-B- 182A-207)
  • Chang KP, Lee LY, Yeh AR, Dai TS, Hao SP. Endoscopic CO2 Laser Surgery for an Atypical Carcinoid Tumor of the Epiglottis Masquerading as a Supraglottic Cyst. Head Neck. 2005; November; 27(11):1004-1007. (SCI, IF=2.276; Otorhinolaryngology 11/42)
  • Chang KP, Chen YL, Hao SP, Chen SM. Echo-guided closed drainage for abscesses of the head and neck. Otolaryngol Head Neck Surg. 2005; January; 132(1):119-124. (SCI, IF=2.021; Otorhinolaryngology 11/43)
  • Chang KP, Hao SP, Tsang NM, Ueng SH. Salvage surgery for locally recurrent nasopharyngeal carcinomas -A 10-year experience. Otolaryngol Head Neck Surg. 2004; October; 131(4): 497-502. (SCI, IF=2.76 ; Otorhinolaryngology 3/43)
  • Chang KP, Huang TS, Hsu HC, Su SY. Cochlear implantation in a post-irradiated patient for nasopharyngeal carcinoma. Cochlear Implants International. 2004: S1(5): 227
  • Chang KP, Hao SP, Lin SY, Tsao KC, Kuo Tt, Tsai MS, Tsang NM. A lack of association of p53 mutations and recurrent nasopharyngeal carcinoma refractory to radiotherapy. Laryngoscope. 2002; November; 112: 2015-2019. (SCI, IF=2.272; Otorhinolaryngology 9/43) (NSC 87-2314-B182A-003)
  • Treatment results of snoring and sleep apnea in children.
  • Endoscopic management of skull base osteoradionecrosis.
  • Embedded retropharyngeal foreign body- report of two cases.
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