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吳逸如 醫師

巴金森氏症、肉毒桿菌素注射、遺傳型神經退化性疾病、神經肌肉疾病及動作障礙

教職 : 教授

醫師網路掛號

※直接點選進入醫師網路掛號畫面※

語言

  • 國語,英語

現職

  • 林口長庚紀念醫院神經內科部副部主任
  • 林口長庚紀念醫院神經內科教授級主治醫師

學歷

  • 中山醫學院醫學系學士

經歷

  • 亞太區動作障礙學會理事
  • 世界神經學會教育委員
  • 亞太區動作障礙學會教育委員
  • 台灣動作障礙學會理事長
  • 林口長庚紀念醫院神經內科病房主任
  • 林口長庚紀念醫院神經內科主治醫師
  • 林口長庚紀念醫院神經內科住院醫師

學會與認證

  • 台灣動作障礙學會理事長
  • 台灣神經學學會
  • 臺灣醫學會
  • 神經科專科醫師證書
  • 神經重症專科醫師證書

論文及期刊發表

  • Role of LRP10 in Parkinson's disease in a Taiwanese cohort.
  • Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan.
  • "Hot cross bun" is a potential imaging marker for the severity of cerebellar ataxia in MSA-C.
  • Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation.
  • Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
  • Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
  • Rare VPS35 A320V Variant in Taiwanese Parkinson's Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology.
  • Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.
  • Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.
  • Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
  • Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
  • Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
  • Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
  • New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models.
  • Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease.
  • Association of genetic variants within HLA-DR region with Parkinson's disease in Taiwan.
  • Association of RIT2 and RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and a meta-analysis in Asian populations.
  • Delivering patient-centered care in Parkinson's disease: Challenges and consensus from an international panel.
  • Plasma and Serum Alpha-Synuclein as a Biomarker of Diagnosis in Patients With Parkinson's Disease.
  • Does the M.D. Anderson Dysphagia Inventory correlate with dysphagia-limit and the Unified Parkinson Disease Rating Scale in early-stage Parkinson's disease?
  • Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
  • Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson's Disease.
  • Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
  • CCM1 and CCM2 variants in patients with cerebral cavernous malformation in an ethnically Chinese population in Taiwan.
  • Parkinson's disease in the Western Pacific Region.
  • Using global team science to identify genetic parkinson's disease worldwide.
  • Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease.
  • POLG R964C and GBA L444P mutations in familial Parkinson's disease: Case report and literature review.
  • Anxiety and Levodopa Equivalent Daily Dose Are Potential Predictors of Sleep Quality in Patients With Parkinson Disease in Taiwan.
  • Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
  • J Alzheimers Dis. 2019;67(2):737-756. doi: 10.3233/JAD-180643.
  • Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.
  • Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
  • Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
  • Home-Based Orolingual Exercise Improves the Coordination of Swallowing and Respiration in Early Parkinson Disease: A Quasi-Experimental Before-and-After Exercise Program Study.
  • Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease.
  • Predictive Factors for Early Initiation of Artificial Feeding in Patients With Sporadic Creutzfeldt-Jakob Disease.
  • Analysis of GWAS-linked variants in multiple system atrophy.
  • The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
  • Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
  • Catechol-O-methyltransferase (COMT) genetic variants are associated with cognitive decline in patients with Parkinson's disease.
  • DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.
  • Atypical presentation of dopa-responsive dystonia in Taiwan.
  • Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy.
  • Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
  • Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
  • Non-invasive assessment determine the swallowing and respiration dysfunction in early Parkinson's disease.
  • Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease.
  • Cross-Cultural Differences of the Non-Motor Symptoms Studied by the Traditional Chinese Version of the International Parkinson and Movement Disorder Society- Unified Parkinson's Disease Rating Scale.
  • Patterns of False Memory in Patients with Huntington's Disease.
  • Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.
  • Genome-wide association study of Parkinson's disease in East Asians.
  • Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression.
  • Positive Effects of Specific Exercise and Novel Turning-based Treadmill Training on Turning Performance in Individuals with Parkinson's disease: A Randomized Controlled Trial.
  • Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barre syndrome.
  • The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1.
  • Relationships among Depression, Anxiety, Sleep, and Quality of Life in Patients with Parkinson's Disease in Taiwan.
  • Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
  • Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays.
  • Metabolic disturbances in plasma as biomarkers for Huntington's disease.
  • The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease.
  • Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan.
  • Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan.
  • Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease.
  • Memory for gist and detail information in patients with Parkinson's disease.
  • Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese.
  • STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan.
  • Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.
  • Integrated non-invasive measurements reveal swallowing and respiration coordination recovery after unilateral stroke.
  • High Protein Diet and Huntington's Disease.
  • Protein Kinase Cη Polymorphism and the Susceptibility to Ischemic Stroke in the Taiwan Population.
  • The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.
  • Wegener's granulomatosis with nervous system involvement: a hospital-based study.
  • Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis.
  • Virtual Reality-Based Training to Improve Obstacle-Crossing Performance and Dynamic Balance in Patients With Parkinson's Disease.
  • Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients.
  • Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica.
  • High frequency of SPG4 in Taiwanese families with autosomal dominant hereditary spastic paraplegia.
  • Plasma inflammatory biomarkers for Huntington's disease patients and mouse model.
  • The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems.
  • Taiwan Severe Cutaneous Adverse Reaction Consortium; Japan Pharmacogenomics Data Science Consortium. Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.
  • FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease.
  • Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan.
  • Tract-based spatial statistics: application to mild cognitive impairment.
  • Factors influencing turning and its relationship with falls in individuals with Parkinson's disease.
  • Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.
  • Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
  • Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function. Parkinsonism Relat Disord.
  • Factors influencing obstacle crossing performance in patients with Parkinson's disease.
  • Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3.
  • Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17.
  • Genetic Variants ofLRRK2 in Taiwanese Parkinson's Disease.
  • HTRA2 variations in Taiwanese Parkinson's disease.
  • Sex dimorphism of cortical water diffusion in normal aging measured by magnetic resonance imaging.
  • The experiences of taiwanese older individuals at different stages of Parkinson disease.
  • Internal Ribosome Entry Segment Activity of ATXN8 Opposite Strand RNA.
  • SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population.
  • Genetic variations of GAK in two Chinese Parkinson's disease populations: a case-control study.
  • Identification of a novel risk variant in the FUS gene in essential tremor.
  • Long-term follow-up of spinal and bulbar muscular atrophy in Taiwan.
  • Association between PARK16 and Parkinson's disease in the Han Chinese population: a meta-analysis.
  • Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation.
  • Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.
  • Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3.
  • Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis.
  • A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome.
  • Genetic analysis of NFE2L2 promoter variation in Taiwanese Parkinson's disease.
  • Downregulation of genes involved in metabolism and oxidative stress in the peripheral leukocytes of Huntington's disease patients.
  • Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population.
  • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies.
  • LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations.
  • Effect of statin treatment on adrenomyeloneuropathy with cerebral inflammation: A revisit.
  • ATXN8 -62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease.
  • Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease.
  • Identification of gene networks and pathways associated with guillain-barre syndrome.
  • LINGO-2 polymorphism and risk of Parkinson's disease in Taiwan.
  • Are there ethnic differences in Impulsive/Compulsive behaviors in Parkinson's disease?