跳到主要內容
:::

張東杰

林口長庚醫院放射腫瘤科主治醫師

放射腫瘤科

鼻咽癌治療及研究、頭頸部腫瘤治療及研究、上消化道腫瘤治療及研究、顱外放射手術、臨床放射腫瘤學、癌症病患生活品質之研究、醫療經濟及醫療成本效益之研究、放射腫瘤近接治療、腫瘤生物學、自由基和癌症生成與預後之關係、乳癌腫瘤治療及研究

教職 : 教授

醫師網路掛號

※直接點選進入醫師網路掛號畫面※

語言

  • 國語,英語,閩南語

現職

  • 林口長庚醫院放射腫瘤科主治醫師
  • 長庚大學教授

學歷

  • 台北醫學院醫學系畢業
  • 長庚大學醫務管理研究所畢業

經歷

  • 長庚醫院林口醫學中心 教授、主治醫師
  • 長庚大學醫學院 兼任教授

學會與認證

  • 中華民國放射腫瘤學會
  • 中華民國放射線醫學會
  • 中華民國臨床腫瘤學會
  • 中華民國癌症醫學會
  • 中華民國放射物理學會
  • 台灣醫學會
  • 美國放射腫瘤學會
  • 美國癌症研究學會
  • 歐洲放射腫瘤學會

論文及期刊發表

  • Proteomics Analysis Reveals Involvement of Krt17 in Areca Nut-Induced Oral Carcinogenesis.
  • Outcomes and prognostic factors for surgery followed by modern radiation therapy in parotid gland carcinomas.
  • Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells.
  • Induction chemotherapy with dose-modified docetaxel, cisplatin, and 5-fluorouracil in Asian patients with borderline resectable or unresectable head and neck cancer.
  • Preoperative SCC Antigen, CRP Serum Levels, and Lymph Node Density in Oral Squamous Cell Carcinoma.
  • miR-196, an emerging cancer biomarker for digestive tract cancers.
  • Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study.
  • RGD-K5 PET/CT in patients with advanced head and neck cancer treated with concurrent chemoradiotherapy: Results from a pilot study.
  • Dynamic contrast-enhanced MRI, diffusion-weighted MRI and 18F-FDG PET/CT for the prediction of survival in oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiation.
  • Overweight and obesity predict better overall survival rates in cancer patients with distant metastases.
  • Heterogeneity of (18) F-FDG PET combined with expression of EGFR may improve the prognostic stratification of advanced oropharyngeal carcinoma.
  • Human Papillomavirus Infections are Common and Predict Mortality in a Retrospective Cohort Study of Taiwanese Patients With Oral Cavity Cancer.
  • Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies.
  • Fascin is a circulating tumor marker for head and neck cancer as determined by a proteomic analysis of interstitial fluid from the tumor microenvironment.
  • Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma.
  • Changes and predictors of radiation-induced oral mucositis in patients with oral cavity cancer during active treatment.
  • Zone-size nonuniformity of 18F-FDG PET regional textural features predicts survival in patients with oropharyngeal cancer.
  • Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer.
  • The role of elective neck dissection in early stage buccal cancer.
  • Clinical Utility of Multimodality Imaging with Dynamic Contrast-Enhanced MRI, Diffusion-Weighted MRI, and 18F-FDG PET/CT for the Prediction of Neck Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiation.
  • Human papillomavirus 16/18 E7 viral loads predict distant metastasis in oral cavity squamous cell carcinoma.
  • OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway.
  • Concurrent chemoradiotherapy using cisplatin, tegafur, and leucovorin for advanced squamous cell carcinoma of the hypopharynx and oropharynx.
  • Unmet supportive care needs and characteristics of family caregivers of patients with oral cancer after surgery.
  • Prognostic value of prepontine cistern invasion in nasopharyngeal carcinoma treated by intensity-modulated radiotherapy.
  • Postoperative concomitant chemoradiotherapy improved treatment outcomes of patients with oral cavity cancer with multiple-node metastases but no other major risk factors.
  • Refining the role of preoperative C-reactive protein by neutrophil/lymphocyte ratio in oral cavity squamous cell carcinoma.
  • Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype.
  • Prognostic implications of post-therapy 18F-FDG PET in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.
  • Textural features of pretreatment 18F-FDG PET/CT images: prognostic significance in patients with advanced T-stage oropharyngeal squamous cell carcinoma.
  • Cisplatin, tegafur-uracil and leucovorin plus mitomycin C: an acceptably effective and toxic regimen for patients with recurrent or metastatic nasopharyngeal carcinoma.
  • Dynamic Contrast-Enhanced MR Imaging Predicts Local Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiotherapy.
  • Supportive care needs in newly diagnosed oral cavity cancer patients receiving radiation therapy.
  • DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway.
  • An International Collaboration to Harmonize the Quantitative Plasma Epstein-Barr Virus (EBV) DNA Assay for Future Biomarker-Guided Trials in Nasopharyngeal Carcinoma.
  • Pretreatment (18)F-FDG PET standardized uptake value of primary tumor and neck lymph nodes as a predictor of distant metastasis for patients with nasopharyngeal carcinoma.
  • Postoperative radiotherapy of intracranial ependymoma.
  • Radiation retinopathy following radiation therapy in nasopharyngeal tumor patients.
  • The role of brachytherapy in early stage nasopharyngeal carcinoma.
  • Intraoperative high dose rate brachytherapy.
  • Acute toxicities and feasibility of altered fractionated radiotherapy in nasopharyngeal carcinoma.
  • Nasopharyngeal carcinoma: MR and CT evaluation.
  • Inguinal lymph node radiotherapy for female patients.
  • Diagnostic efficacy of a monoclonal antibody-based sandwich enzyme linked immunosorbent assay procedure for quantitation of prostatic acid phosphatase.
  • Endocrine dysfunction in patients with nasopharyngeal carcinoma after radiotherapy – a prospective study with 10 years follow-up.
  • MRI of nasopharyngeal carcinoma with emphasis on relationship to radiotherapy.
  • Telomerase activity in benign and malignant human thyroid tissues.
  • Early stage nasopharyngeal carcinoma: radiotherapy dose and time factors in tumor control.
  • The prognostic significance of pre- and post- treatment SCC level in patients with squamous cell carcinoma of the cervix treated by irradiation.
  • Posoperative Radiotherapy for adult intracranial low-grade astrocytoms.
  • Postoperative radiotherapy of adult supratentorial high-grade astrocytoma.
  • Polymerase chain reaction-based enzyme immunoassay for quantitation of telomerase activity: application to colorectal cancers.
  • The prognostic factors for patients with early cervical cancer treated by radical hysterectomy and postoperative radiotherapy.
  • MRI in recurrent nasopharyngeal carcinoma.
  • Locally recurrent nasopharyngeal carcinoma.
  • Randomized Trial of Neoadjuvant Cisplatin, Vincristine, Bleomycin, and Radical Hystectomy Versus Radiation Therapy for Bulky Stage Ib and IIa Cervical Cancer.
  • Telomerase activity is frequently found in metastatic and malignant nasopharyngeal tissues.
  • The effect of nodal status on determinants of initial treatment response and patterns of relapse-free survival in nasopharyngeal carcinoma.
  • Junction Techniques for pharynx and neck treatment.
  • Comparison of treatment plans for nasopharyngeal carcinoma: bil-lateral opposing, 3D conformal and intensity modulated radiotherapy.
  • Treatment of nasopharyngeal carcinoma with unusual histological features.
  • Poor prognosis in nasopharyngeal cancer patients with low level of glucose-6-phosphate dehydrogenase.
  • Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese.
  • Isolated paraaortic lymph node recurrence after definitive irradiation for cervical carcinoma.
  • Intracavity Brachytherapy for nasopharyngeal carcinoma with Rotterdam Nasopharyngeal Applicator.
  • Prediction of Supraclavicular Lymph Node Metastasis in Breast Cancer.
  • Cisplatin, Tegafur, and Leucovorin, A moderately effective and minimally toxic putpatient neoadjuvant chemotherapy for locally advanced squamous cell carcinoma of the head and neck.
  • Differential Regulation of telomerase activity by six telomerase subunits.
  • Quantitative analysis of multidrug-resistance mdr1 gene expression in head and neck cancer by real-time RT-PCR.
  • A reverse transcription comparative real-time PCR method for quantitative detection of angiogenic growth factors in head and neck cancer patients.
  • The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas.
  • Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. )
  • Lack correlation of betel nut, tobacco smoking or alcohol consumption with telomerase activity and the severity of oral cancer.
  • Radiotherapy of early-stage glottic cancer: analysis of factors affecting prognosis.
  • Surgical treatment of oral verrucous carcinoma.
  • Symptom distress, catastrophic thinking, and hope in nasopharyngeal carcinoma patients.
  • Linear accelerator-based radiosurgery in the management of skull base meningiomas.
  • False positive fluorine-18 fluorodeoxy-D-glucose positron emission tomography finding caused by osteoradionecrosis in a nasopharyngeal carcinoma patient.
  • Contemporary management of penile cancer including surgery and adjuvant radiotherapy: an experience in Taiwan.
  • Fluoroscopically guided percutaneous gastrostomy with modified gastropexy and a large-bore balloon-retained catheter in patients with head and neck tumors.
  • Telomerase as an independent prognostic factor in head and neck squamous cell carcinoma.
  • Recent advances in the treatment of nasopharyngeal carcinoma.
  • Enzyme immunoassay for serum autoantibody to survivin and its findings in head and neck cancer patients.
  • Nodal metastases of nasopharyngeal carcinoma: patterns of disease on MRI and FDG PET.
  • Nasopharyngeal carcinoma patients with questionable MRI findings for recurrence.
  • Biweekly Pacitaxel, Cisplatin, Tegafur and Lwucovorin as Neoadjuvant Chemotherapy for unresectable squamous cell carcinoma of the head and neck.
  • Are dual-phase (18)F-FDG PET scans necessary in nasopharyngeal carcinoma to assess the primary tumour and loco-regional nodes?
  • p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan.
  • False-positive findings on F-18 fluoro-2-deoxy-D-glucose positron emission tomography in a patient with nasopharyngeal carcinoma and extensive sinusitis.
  • The value of 18F-FDG PET in the detection of stage M0 carcinoma of the nasopharynx.
  • Phase II trial of cisplatin, tegafur plus uracil and leucovorin as neoadjuvant chemotherapy in patients with squamous cell carcinoma of the oropharynx and hypopharynx.
  • Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: comparison with head and neck CT/MRI and histopathology.
  • Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): over-expression of NPM, CDK1, NDRG1 and under-expression of CHES1.
  • Nasopharyngeal carcinoma staging PDG PET.
  • 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation.
  • Upstream stimulatory factor (USF) as a transcriptional suppressor of human telomerase reverse transcriptase (hTERT) in oral cancer cells.
  • Nasopharyngeal carcinoma with cranial palsy: the importance of MRI for radiotherapy.
  • Oral Cancer Plasma Tumor Marker Identified with Bead-Based Affinity Fractionated Proteomic Technology.
  • [18F]fluorodeoxyglucose positron emission tomography is more sensitive than skeletal scintigraphy for detecting bone metastasis in endemic nasopharyngeal carcinoma at initial staging.
  • T-fastener gastropexy and percutaneous gastrostomy under CT-fluoroscopic guidance in a patient with partial gastrectomy.
  • hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells.
  • Advantages and pitfalls of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography in detecting locally residual or recurrent nasopharyngeal carcinoma: comparison with magnetic resonance imaging.
  • Surgical outcome of T4a and resected T4b oral cavity cancer.
  • T4b oral cavity cancer below the mandibular notch is resectable with a favorable outcome.
  • Higher distant failure in young age tongue cancer patients.
  • (18)F-FDG-PET for evaluation of the response to concurrent chemoradiation therapy with intensity-modulated radiation technique for Stage T4 nasopharyngeal carcinoma.
  • Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan.
  • Differential Roles of 18F-FDG PET in Patients with Locoregional Advanced Nasopharyngeal Carcinoma After Primary Curative Therapy: Response Evaluation and Impact on Management.
  • Prospective study of [18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck.
  • Increase diagnostic efficacy by combined use of fingerprint markers in mass spectrometry-Plasma peptidomes from nasopharyngeal cancer patients for example.
  • DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis.
  • Combined-modality treatment for advanced oral tongue squamous cell carcinoma.
  • Postirradiation sinus mucosa disease in nasopharyngeal carcinoma patients.
  • Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15.
  • Health-related quality of life and patient satisfaction after treatment for breast cancer in northern Taiwan.
  • Survival in squamous cell carcinoma of the oral cavity: differences between pT4 N0 and other stage IVA categories.
  • Intractable bleeding from solitary mandibular metastasis of hepatocellular carcinoma.
  • Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area.
  • Analysis of risk factors for distant metastases in squamous cell carcinoma of the oral cavity.
  • 18F-FDG PET can replace conventional work-up in primary M staging of nonkeratinizing nasopharyngeal carcinoma.
  • Salvage therapy in relapsed squamous cell carcinoma of the oral cavity: How and when?
  • High Incidence of Malignant Transformation of Laryngeal Papilloma in Taiwan.
  • Analysis of Risk Factors of Predictive Local Tumor Control in Oral Cavity Cancer.
  • Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection.
  • Treatment outcome of combined modalities for buccal cancers: unilateral or bilateral neck radiation?
  • Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion?
  • When does skin excision allow the achievement of an adequate local control rate in patients with squamous cell carcinoma involving the buccal mucosa?
  • Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis.
  • Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.
  • Internal consistency of the traditional Chinese character version of the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N).
  • Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of (18)F-FDG PET and extended-field multi-detector row CT.
  • Risk Stratification of Patients with Oral Cavity Squamous Cell Carcinoma and Contralateral Neck Recurrence Following Radical Surgery.
  • Pretreatment Primary Tumor SUVmax Measured by FDG-PET and Pathologic Tumor Depth Predict for Poor Outcomes in Patients with Oral Cavity Squamous Cell Carcinoma and Pathologically Positive Lymph Nodes.
  • Staging of untreated nasopharyngeal carcinoma with PET/CT: comparison with conventional imaging work-up.
  • Prediction for distant failure in patients with stage M0 nasopharyngeal carcinoma: The role of standardized uptake value.
  • Preoperative [18F]Fluorodeoxyglucose Positron emission tomography standardized uptake value of neck lymph nodes predicts neck cancer control and survival rates in patients with oral cavity squamous cell carcinoma and pathologically positive lymph nodes.
  • Pretreatment evaluation of distant-site status in patients with nasopharyngeal carcinoma: accuracy of whole-body MRI at 3-Tesla and FDG-PET-CT.
  • Distress and care needs in newly diagnosed oral cavity cancer patients receiving surgery.
  • Transcriptome profiling and network pathway analysis of genes associated with invasive phenotype in oral cancer.
  • Preoperative [(18)F]-fluorodeoxyglucose positron emission tomography standardized uptake value of neck lymph nodes may aid in selecting patients with oral cavity squamous cell carcinoma for salvage therapy after relapse.
  • Unmet information needs and preferences in newly diagnosed and surgically treated oral cavity cancer patients.
  • Support needs of patients with oral cancer and burden to their family caregivers.
  • Hypothyroidism after radiotherapy for nasopharyngeal cancer patients.
  • 18F-FDG PET for retropharyngeal lymph node metastasis in oropharyngeal and hypopharyngeal cancers: impact on diagnosis and prediction analysis.
  • Transdermal Fentanyl for Pain Caused by Radiotherapy in Head and Neck Cancer Patients Treated in an Outpatient Setting: a Multicenter Trial in Taiwan.
  • Influence of pathological nodal status and maximal standardized uptake value of the primary tumor and regional lymph nodes on treatment plans in patients with advanced oral cavity squamous cell carcinoma.
  • Treatment Results of Postoperative Radiotherapy on Squamous Cell Carcinoma of the Oral Cavity: Coexistence of Multiple Minor Risk Factors Results in Higher Recurrence Rates.
  • Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy.
  • Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions.
  • Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT.
  • Proteomics of the radioresistant phenotype in head-and-neck cancer: GP96 as a novel prediction marker and sensitizing target for radiotherapy.
  • Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary--an experience in Taiwan.
  • Primary tumor site as a predictor of treatment outcome for definitive radiotherapy of advanced stage oral cavity cancers.
  • Highly potent and specific siRNAs against E6 or E7 genes of HPV16- or HPV18-infected cervical cancers.
  • Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract.
  • Orofacial pain and predictors in oral squamous cell carcinoma patients receiving treatment.
  • Psychometric testing of the Chinese-version cancer needs questionnaire short form head and neck cancer-specific version in oral cavity cancer patients.
  • PET/CT and 3-T whole-body MRI in the detection of malignancy in treated oropharyngeal and hypopharyngeal carcinoma.
  • Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer.
  • GP96 is over-expressed in oral cavity cancer and is a poor prognostic indicator for patients receiving radiotherapy.
  • Clinical utility of 18F-FDG PET parameters in patients with advanced nasopharyngeal carcinoma: predictive role for different survival endpoints and impact on prognostic stratification.
  • Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling.
  • Impact of Pretreatment Body Mass Index on Patients With Head-and-Neck Cancer Treated With Radiation.
  • CD4+ T Cells Disarm or Delete Cytotoxic T Lymphocytes under IL-17-Polarizing Conditions.
  • Transoral Laser Microsurgery Elevates Fundamental Frequency in Early Glottic Cancer.
  • Prognostic value of pretreatment (18)F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma.
  • The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity.
長庚醫院智能服務 有任何問題隨時找我!