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陳瓊美 醫師

巴金森氏症、小腦萎縮、亨丁頓舞蹈症、動作障礙疾病、遺傳性神經性疾病

教職 : 教授

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語言

  • 國語,英語

現職

  • 林口長庚紀念醫院神經內科教授級主治醫師

學歷

  • 台北醫學院醫學系學士
  • 英國格拉斯哥大學醫學博士

經歷

  • 林口長庚紀念醫院神經內科主治醫師
  • 林口長庚紀念醫院神經內科住院醫師

學會與認證

  • 台灣神經學學會
  • 台灣動作障礙學會
  • 神經科專科醫師證書
  • 神經重症專科醫師證書

論文及期刊發表

  • Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan.
  • Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation.
  • X-linked adrenoleukodystrophy caused by a novel mutation presenting with various phenotypes in a Taiwanese family.
  • Clin Chim Acta. 2021 Jan 8;514:100-106. doi: 10.1016/j.cca.2020.12.017. Online ahead of print.
  • Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
  • Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
  • Differences in Clinical Presentation of Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease According to Sex and Education Level.
  • Rare VPS35 A320V Variant in Taiwanese Parkinson's Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology.
  • Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.
  • Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
  • Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
  • The Role of Oxidative Stress in Parkinson's Disease.
  • Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus.
  • Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
  • New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models.
  • Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease.
  • Association of genetic variants within HLA-DR region with Parkinson's disease in Taiwan.
  • Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment.
  • Association of RIT2 and RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and a meta-analysis in Asian populations.
  • Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
  • Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons.
  • Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
  • Generation of induced pluripotent stem cells from a young-onset Parkinson'sdisease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations.
  • Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model.
  • Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease.
  • Modeling Alzheimer's Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation.
  • Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
  • Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
  • Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
  • Persistence and adherence to rivastigmine in patients with dementia: Results from a noninterventional, retrospective study using the National Health Insurance research database of Taiwan.
  • Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
  • Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.
  • Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
  • Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.
  • Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.
  • Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
  • Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
  • Lipophilic antioxidants in neurodegenerative diseases.
  • Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease.
  • The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
  • Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
  • DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.
  • Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy.
  • Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
  • Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
  • Non-alcoholic Wernicke's encephalopathy with cortical involvement and polyneuropathy following gastrectomy.
  • Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome.
  • Alterations of plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre syndrome.
  • Patterns of False Memory in Patients with Huntington's Disease.
  • Genome-wide association study of Parkinson's disease in East Asians.
  • Targeting ENT1 and adenosine tone for the treatment of Huntington's disease. Hum Mol Genet.
  • Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
  • Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression.
  • Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barre syndrome.
  • Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model.
  • Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels.
  • Metabolic disturbances in plasma as biomarkers for Huntington's disease.
  • The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease.
  • Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease.
  • Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan.
  • Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan.
  • Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.
  • Polymorphisms in the Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population.
  • STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan.
  • Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese.
  • Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.
  • Protein Kinase Cη Polymorphism and the Susceptibility to Ischemic Stroke in the Taiwan Population.
  • High Protein Diet and Huntington's Disease.
  • The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.
  • Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population.
  • Biomarkers for neuromyelitis optica.
  • Plasma Inflammatory biomarkers for Huntington's disease patients and mouse model.
  • Role of High Mobility Group Box 1 (HMGB1) in SCA17 Pathogenesis.
  • The potential of indole and a synthetic derivative for polyQ aggregationreduction by enhancement of the chaperone and autophagy systems.
  • Deactivation of TBP contributes to SCA17 pathogenesis.
  • FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease
  • Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease
  • Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
  • Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function
  • Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3.
  • Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17.
  • HTRA2 variations in Taiwanese Parkinson's disease.
  • Genetic variants of LRRK2 in Taiwanese Parkinson's disease
  • Association between PARK16 and Parkinson's disease in the Han Chinese population: a meta-analysis
  • Internal Ribosome Entry Segment Activity of ATXN8 Opposite Strand RNA.
  • SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population.
  • Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study
  • A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome
  • Identification of a novel risk variant in the FUS gene in essential tremor
  • Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population
  • Mutations of proline-rich transmembrane protein-2 and paroxysmal kinesigenic dyskinesia in Taiwan
  • Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
  • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-aquaporin 4 antibodies
  • Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis
  • Genetic analysis of NFE2L2 promoter variation in Taiwanese Parkinson's disease
  • ATXN8 -62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease
  • Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients
  • Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population
  • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies. Mult Scler
  • LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations
  • Role of the CCAAT-Binding Protein NFY in SCA17 Pathogenesis
  • Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease
  • LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan
  • Identification of Gene Networks and Pathways Associated with Guillain-Barre Syndrome.
  • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies