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羅淑芬 醫師

過敏病學、免疫學、風濕病學、內科學

教職 : 教授

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語言

  • 國語,英語,閩南語

現職

  • 主治醫師
  • 臨床組教授

學歷

  • 台灣大學醫學系

經歷

  • 臺大醫院住院醫師
  • 長庚紀念醫院學術組教授
  • 臺大醫院住院總醫師
  • 長庚紀念醫院臨床組教授
  • 長庚紀念醫院風濕過敏免疫科主任
  • 臺大醫院住院主治醫師
  • 紐約西奈山醫院研究員
  • 長庚紀念醫院風濕過敏免疫科主任
  • 長庚紀念醫院主治醫師

學會與認證

  • Chinese License NO.醫字第006194號, 北市衛醫執字3650號
  • 中華民國骨質疏鬆症醫學會華骨鬆(福)證第013號
  • Certified Physician Investigator
  • 中免專醫字第046號
  • 中僂專醫字019號
  • 內專醫字第1554號
  • 中華民國風濕病醫學會理事長 (曾任)
  • 中華民國風濕病醫學會秘書長 (曾任)
  • 中華民國風濕病雜誌總編輯(曾任)
  • 亞太風濕病醫學會副理事長 (曾任)
  • 中華民國免疫學會理事(現任)
  • 中華民國骨質疏鬆症學會理事 (現任)
  • 中華民國風濕病醫學會理事(現任)

論文及期刊發表

  • Separation and Purification of Myeloma Proteins.
  • Hyperthyroid and hypothyroid status was strongly associated with gout and weakly associated with hyperuricaemia.
  • Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.
  • Epidemiology and management of gout in Taiwan: a nationwide population study.
  • Survival impact of serum uric acid levels in children and adolescents .
  • Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial.
  • Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA).
  • Survival impact of serum uric acid levels in children and adolescents .
  • Discontinuation of anti-TNF-α therapy in a Chinese cohort of patients with rheumatoid arthritis.
  • Increased risk of cancer among gout patients: A nationwide population study.
  • Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality.
  • Risk of myocardial infarction among patients with gout: a nationwide population-based study.
  • Elevated risk of mortality among gout patients: A comparison with the National Population in Taiwan .
  • Survival analysis of patients with dermatomyositis and polymyositis : Analysis of 192 Chinese cases.
  • CSE1L, a novel microvesicle membrane protein, mediates Ras-triggered microvesicle generation and metastasis of tumor cells.
  • Major Adverse Cardiovascular Events and Mortality in Systemic Lupus Erythematosus Patients After Successful Delivery: A Population-Based Study.
  • Risk of end-stage renal disease associated with gout: a nationwide population study.
  • Rheumatoid arthritis prevalence, incidence, and mortality rates: a nationwide population study in Taiwan.
  • Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB.
  • Cancer risk among patients with systemic sclerosis: a nationwide population study in Taiwan.
  • Genetic variations in the C epsilon mX domain of human membrane-bound IgE.
  • Antinuclear antibody status and risk of death in children and adolescents.
  • Incidence, cancer risk and mortality of dermatomyositis and polymyositis in Taiwan: a nationwide population study.
  • Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1β via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-κB activity in human rheumatoid arthritis synovial fibroblasts.
  • Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells.
  • TLR4-dependent induction of vascular adhesion molecule-1 in rheumatoid arthritis synovial fibroblasts Roles of cytosolic phospholipase A(2)alphacyclooxygenase-2.
  • Hyperuricaemia and accelerated reduction in renal function.
  • Epidemiology and mortality of systemic sclerosis: a nationwide population study in Taiwan.
  • Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells.
  • Differential involvement of PKC-dependent MAPKs activation in lipopolysaccharide-induced AP-1 expression in human tracheal smooth muscle cells.
  • Infections in polymyositis and dermatomyositis: analysis of 192 cases.
  • Better short-term clinical response to etanercept in Chinese than Caucasian patients with active ankylosing spondylitis.
  • Role of uric acid in the link between arterial stiffness and cardiac hypertrophy: a cross-sectional study.
  • Impending Cardiac Tamponade as the Initial Presentation of Thymoma In a Systemic Lupus Erythematosus Patient.
  • Gout and risk of non-alcoholic fatty liver disease.
  • Predictors of disability in Taiwanese patients with rheumatoid arthritis.
  • Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress.
  • IL-1beta induces urokinse-plasminogen activator expression and cell migration through PKCalpha, JNK1/2, and NF-kappaB in A549 cells.
  • Gout: an independent risk factor for all-cause and cardiovascular mortality.
  • Involvement of MAPKs and NF-κB in TNF-α-Induced VCAM-1 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.
  • Acetylsalicylic acid regulates MMP-2 activity and inhibits colorectal invasion of murine B16F0 melanoma cells in C57BL/6J mice: effects of prostaglandin F(2)alpha.
  • Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells.
  • Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.
  • Interstitial lung disease in polymyositis and dermatomyositis.
  • Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells.
  • Vascular response of Raynaud's phenomenon to nifedipine or herbal medication (duhuo-tisheng tang with danggui-sini tang): a preliminary study.
  • Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation.
  • Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis.
  • Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells.
  • Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
  • Synergic CSE1L/CAS, TNFR-1, and p53 apoptotic pathways in combined interferon-gamma/adriamycin-induced apoptosis of Hep G2 hepatoma cells.
  • Right subclavian vein thrombosis associated with Rofecoxib treatment in a patient with progressive systemic sclerosis.
  • Coexisting ankylosing spondylitis and gouty arthritis.
  • The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE.
  • Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients.
  • Interleukin-1b Induces MMP-9 Expression Via p42/p44 MAPK, p38 MAPK, JNK, and Nuclear Factor-kB Signaling Pathways in Human Tracheal Smooth Muscle Cells.
  • Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells.
  • Successful preventive treatment of congenital heart block during pregnancy in a woman with systemic lupus erythematosus and anti-Sjogren's syndrome A/Ro antibody.
  • Involvement of p42/p44 MAPK, p38 MAPK, JNK and NF-κ B in Interleukin-1β-induced VCAM-1 Expression in Human Tracheal Smooth Muscle Cells.
  • Transactivation of Src, PDGF receptor, and Akt is involved in IL-1β-induced ICAM-1 expression in A549 cells.
  • TNF-{alpha} induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-{kappa}B/p300 binding in human tracheal smooth muscle cells.
  • Elevated serum homocysteine levels for gouty patients.
  • Involvement of p42/p44 MAPK, JNK, and NF-kappa B in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells.
  • Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients.
  • Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappa B pathways.
  • Intermittent elevation of serum urate and 24-hour urinary uric acid excretion.
  • Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappa B pathways.
  • Gout complicated with necrotizing fasciitis--report of 15 cases.
  • Fcgamma receptor IIa, IIIa, and IIIb polymorphisms of systemic lupus erythematosus in Taiwan.
  • Induction of cyclooxygenase-2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-B pathways.
  • Gout in systemic lupus erythematosus and overlap syndrome – a hospital-based study.
  • Concomitant septic and gouty arthritis--an analysis of 30 cases.
  • Younger age of onset of gout in Taiwan.
  • Ankylosing Spondylitis with severe Chondrocalcinosis: Case Report.
  • Hypothyroid Myopathy: A case report.
  • Systemic lupus erythematosus associated with idiopathic hypoparathyroidism.
  • Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial.
  • Inhibitory Effect of Phorbol Ester on Bradykinin-induced Phosphoinositide Hydrolysis and Calcium Mobilization in Cultured Canine Tracheal Smooth Muscle Cells.
  • The morbidity and mortality associated with childhood onset systemic lupus erythematosus.
  • Substance P-induced activation of p42/44 mitogen-activated protein kinase associated with cell proliferation in human tracheal smooth muscle cells.
  • Interleukin-1beta-induced cyclooxygenase-2 expression is mediated through activation of p42/44 and p38 MAPKS, and NF-kappaB pathways in canine tracheal smooth muscle cells.
  • Bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine cultrued tracheal epithelial cell.
  • Salmonella Septic Arthritis in Systemic Lupus Erythematosus and Other Systemic Diseases.
  • Correlation of acoustic velocity of synovial fluid with markers of inflammaties in arihritic patients.
  • Tumour necrosis factor-alpha enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells.
  • Pharmacological Characterization of Bradykinin Receptors in CanineCultured Tracheal Smooth Muscle Cells
  • Ruptured Cerebral Aneurysm in a Patient with Overlap Syndrome and Positive Antiphospholipid Antibody--- A Case Report.
  • Interleukin-1beta enhances bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine tracheal smooth-muscle cells: involvement of the Ras/Raf/mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway.
  • Lipopolysaccharide enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells.
  • Uncoupling of bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization by phorbol ester in canine sultured tracheal epithelial cells.
  • Unusual Coronary artery Ectasia and Stenosis in a Patient with Systemic Lupus Erythematosus and Acute Myocardial Infarction.
  • Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
  • P2Y2 receptor-mediated proliferation of C6 glioma cells via activation of Ras/Raf/MEK/MAPK pathway.
  • Coexistence of Spinal Arteriovenous Malformation and Ankylosing Spondylitis--- Are They Related?
  • Cloning of the American cockroach Cr-PII allergens: Evidence for the existence of cross-reactive allergens between species.
  • The clinical features and prognosis of lupus with disease onset at age 65 and older.
  • The Effect of Cyclic AMP Elevating Agents on Bradykinin- and Carbachol-induced Signal Transduction in Canine Cultured Tracheal Smooth Muscle Cells.
  • A Comparative Evaluationof Tenoxicam and Piroxicam in the Treatment of Osteoarthritis.
  • Total Hip Artroplasty in Salmonella coxitis: Four cases Report.
  • Purinoceptor-stimulated Phosphoinositide Hydrolysis in Madin-Darby Canine Kidney (MDCK) Cells.
  • Effect of Phorbol Ester on Phosphoinositide Hydrolysis and Calcium Mobilization in Cultured Canine Tracheal Smooth Muscle Cells.
  • Acoustic Microscopy of Synovial Fluid with CPPD Crystals.
  • Analysis of cross-reactive allergens from American and German cockroaches by human IgE.
  • Sequencing and Immunochemical Characterization of the American Cockroach Per a 3(Cr-PI) Isoallergenic Variants.
  • Systemic Lupus Erythematosus and Pheochromocytoma.
  • Bradykinin-stimulated Calcium Mobilization in Cultured Canine Tracheal Smooth Muscle Cells.
  • Effect of Forskolin on Bradykinin-Induced Calcium Mobilization in Cultured Canine Tracheal Smooth Muscle Cells.
  • Systemic Lupus Erythematosus and Pheochromocytoma.
  • Bradykinin-stimulated Phospho-inositide Metabolism in Cultured Canine Tracheal Smooth Muscle Cells.
  • Clinical Significance of Synovial Fluid Rice Bodies--- A Case Report and Review of Literature.
  • Rheumatoid Arthritis Complicated with Mononeuritis Multiplex—A report of Two Cases.
  • Psoriatic Arthritis: A Clinical Analysis of One Hundred and Thirty Three Patients.
  • Synovial Fluid Lactate Measurement in Patients of Various Arthritis.
  • Escherichia coli Septic Arthritis-Clinical Analysis.
  • Sequencing Analysis of cDNA Clones Encoding the AmericanCockroach Cr-PI Allergens.
  • Pharmacological and Functional Characterization of Bradykinin Receptors in Canine Cultured Tracheal Epithelial Cells.
  • Retrospective Analysis of 822 Gout Patients.
  • Expression of Cytolytic Mediators by Synovial Fluid Lymphocytes in Rheumatoid Arthritis.
  • Identification of Low Molecular Weight Allergens of American Cockroach and Production of Monoclonal Antibodies.
  • Brachial Artery Aneurysm Rupture in a Patient with Behcet's Disease: Report of a Case.
  • Studies on Structural Units of Human MonoclonalImmunoglobulins.
  • Simultaneous Studies of Serum and Urinary Proteins for Evaluation and Diagnosis of Glomerular Damages in Proteinuric Patients.
  • Metastatic Adenocarcinoma of Synovium Presenting as a Chronic Monoarthritis of Knee: a Case Report and Review of Literature.
  • Ankylosing Spondylitis Complicated with Various Degree Atrioventricular Block: Report of a Case.
  • Effect of Ethanol on Natural Killer Cell Activity in Vitro.
  • The POEMS Syndrome among Chinese: Association with Castleman's Disease and Some Immunological Abnormalities.
  • Separation and Purification of Myeloma Proteins.
  • Neonatal Lupus Erythematosus: Report of a Case.
  • Association of Ankylosing Spondylitis and IgA-Multiple Myeloma: Report of a Case and Pathogenetic Considerations.
  • Immunoelectrophoresis.
  • Double Diffusion.
  • Mosquito Bite Allergy Terminating as HemophagocyticHistiocytosis: Report of a Case.
  • Reiter's Syndrome in Uremia: Report of a Case.
  • Sjogren's Syndrome--20 Studied Cases.
  • Depressed Natural Killer Activity in Graves' Disease and During Antithyroid Medication.
  • Pyomyositis-Report of a Case.
  • Significance of NailfoldCapilloscopy in Patients with Raynaud's Phenomenon.
  • Severe Diphenylhydantoin Hypersensitivity: Analysis of 11 Cases.
  • Natural Killer Cell Activity in Normal Chinese.
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