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王世憲

長庚大學醫學系助理教授

小兒外科

先天性異常手術、胸腹腔鏡微創手術 腹股溝疝氣特別門診

教職 : 助理教授

醫師網路掛號

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語言

  • 國語,英語,閩南語

現職

  • 長庚大學醫學系助理教授
  • 嘉義長庚醫院小兒外科主任
  • 虎尾天主教若瑟醫院小兒外科合約醫師

學歷

  • 長庚大學臨床醫學研究所博士
  • 高雄醫學大學學士後醫學系

經歷

  • 嘉義長庚醫院小兒外科主治醫師
  • 虎尾天主教若瑟醫院小兒外科主治醫師
  • 高雄醫學大學附設醫院外科住院醫師
  • 高雄醫學大學附設醫院小兒外科主治醫師

學會與認證

  • 台灣外科醫學會會員
  • 台灣小兒外科醫學會會員
  • 台灣疝氣醫學會會員

論文及期刊發表

  • 1.Li-Yu Chen, Lee-Wen Chen, Chien-Hui Hung, Chun-Liang Lin, Shie-Shan Wang, Pey-Jium Chang (2022 Jan). Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi’s Sarcoma-Associated Herpesvirus
  • 2. Ju-Bei Yen, Lee-Wen Chen, Ling-Huei Wei, Chien-Hui Hung, Shie-Shan Wang, Chun-Liang Lin, Pey-Jium Chang (2021 Sep). Identification and Characterization of Human Norovirus NTPase Regions Required for Lipid Droplet Localization, Cellular Apoptosis, and Interaction with the Viral P22 Protein Moicrobiology Spectrum, Volume 9 Issue 1: e00422-21.
  • 3.Lee-Wen Chen, Shie-Shan Wang, Chien-Hui Hung , Ya-Hui Hung , Chun-Liang Lin and Pey-Jium Chang (2021 April). The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation. Int. J. Mol. Sci. 2021, 22, 4024. https://doi.org/10.3390/ijms22084024
  • 4.Shih HsienWang*, Ju BeiYen & Sheng Lung Hsu (2020, Oct). The application of single port laparoscopic percutaneous internal ring suture for the management of indirect inguinal hernia in female adults. Scientific Reports: 10:16244 https://doi.org/10.1038/s41598-020-73171-4. 本人為第一及通訊作者
  • 5.Li-Yu Chen, Lee-Wen Chen, Kuo-Ti Peng, Chien-Hui Hung, Pey-Jium Chang, Shie-Shan Wang (2020, Aug). Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters. Journal of Virology, 94(18):e01143-20. 本人為通訊作者
  • 6.Lee-Wen Chen, Chien-Hui Hung, Shie-Shan Wang, Ju-Bei Yen, Ann-Chi Liu, Ya-Hui Huna, Pey-Jium Chang (2018, Aug). Expression and regulation of the BKRF2, BKRF3 and BKRF4 genes of Epstein-Barr virus. Virus Research , 256 (2018) 76–89.
  • 7.Pey-Jium Chang, Lee-Wen Chen, Li-Yu Chen, Chien-Hui Hung, Ying-Ju Shih, Shie-Shan Wang (2017, Oct). Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus. Journal of Virology, October 2017 Volume 91 Issue 19 e00505-17 . 本人為通訊作者
  • 8.Pey-Jium Chang, Yao-Hsu Yang, Pau-Chung Chen, Lee-Wen Chen, Shie-Shan Wang, Ying-Ju Shih, Li-Yu Chen1, Chi-Jen Chen, Chien-Hui Hung and Chun-Liang Lin (2017, Jul). Diabetes and risk of Kaposi’s sarcoma: effects of high glucose on reactivation and infection of Kaposi’s sarcoma-associated herpesvirus. Oncotarget, 2017; 8:80595-80611.
  • 9.Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu*, Pey-Jium Chang* (2016, Oct). Regulation of the Abundance of Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2. PLOS Pathogens, PLOS Pathogens | DOI:10.1371/journal.ppat.1005918 October 3, 2016 1 / 29.
  • 10.Li-Sheng Hsu?, Ju-Bei Yen, Shie-Shan Wang, Chien-Lin Liao (2016 July). A computed tomography phantom study of foam earplugs Uncommon but potentially hazardous foreign body ingestion in children Medicine (2016) 95:35�
  • 11.Pey-Jium Chang, Chien-Hui Hung, Shie-Shan Wang, Ping-Hsin Tsai, Ying-Ju Shih, Li-Yu Chen, Hsiao-Yun Huang, Ling-Huei Wei, Ju-Bei Yen, Chun-Liang Lin, Lee-Wen Chen (2014, Sep). Identification and Characterization of Two Novel Spliced Genes Located in the orf47-orf46-orf45 Gene Locus of Kaposi’s Sarcoma-Associated Herpesvirus. Journal of Virology, 88(17): 10092-10109.
  • 12. Pey-JiumChang*, Shie-ShanWang, Li-YuChen, Chien-HuiHung, Hsiao-YunHuang, Ying-JuShih, Ju-Bei Yen, Jieh-YuanLiou, Lee-WenChen (2013, Jul). ORF50-dependent and ORF50-independent activation of the ORF45 gene of Kaposi's sarcoma-associatedherpesvirus . Virology , 442, 38-50.
  • 13. Shie-Shan Wang, Pey-Jium Chang, Lee-Wen Chen, Li-Yu Chen, Chien-Hui Hung, Jieh-Yuan Liou, Ju-Bei Yen (2012, May). Positive and negative regulation in the promoter of the ORF46 gene of Kaposi's sarcoma-associated herpesvirus. Virus Research, 165 (2012) 157-169. 本人為第一作者
  • 14. Pey-Jium Chang, Lee-Wen Chen, Yan-Chung Shih, Ping-Hsin Tsai, An-Chi Liu, Chien-Hui Hung, Jieh-Yuan Liou, Shie-shan Wang (2011, Mar). Role of the cellular transcriptional factor YY1 in the latent-lytic switch of Kaposi's sarcoma-associated herpesvirus. Virology, 413: 194-204. (SCI)
  • 15. PJ Chang, Joseph Boonsiri, SS Wang, LY Chen and George Miller* (2010, --). Binding of RBPJk (CSL) protein to the promoter of the Kaposi's sarcoma-associated Hherpesvirus ORF47 gene is a critical but not sufficient determinant of transactivation by ORF50 protein. Virology. (SCI).
  • 16. Wang SS, Chen LW, Chen LY, Tsai HH, Shih YC, Yang CT, Chang PJ* (2010, --). Transcriptional regulation of the ORF61 and ORf60 genes of Kaposi's Virology. (SCI). 本人為第一作者.
  • ● 科技部研究計畫 (110年8月~111年7月) 卡波西氏肉瘤病毒 ORF50 蛋白質其 DNA 結合能力受 DNA 結合抑制序列調控的分析 (計畫編號: MOST 111 - 2320 - B - 182 - 026 -)
  • ●長庚醫學研究計畫 (110年1月~112年12月) 卡波西氏肉瘤病毒在溶裂期造成細胞蛋白質Sp3裂解的探討 (計畫編號CMRP110.1-112.12)
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