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張德生 醫師

肝癌超音波介入性治療及藥物治療、B、C型肝炎、消化道內視鏡診療

教職 : 副教授

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語言

  • 國語,英語,閩南語

現職

  • 雲林長庚醫院 胃腸肝膽科 主任
  • 嘉義長庚醫院 胃腸肝膽科 主任
  • 長庚大學中醫系 專任助理教授
  • 嘉義長庚醫院胃腸肝膽科 副教授級主治醫師

學歷

  • 高雄醫學院 醫學系 學士
  • 長庚大學 臨床醫學研究所 博士

經歷

  • 嘉義長庚醫院胃腸肝膽科主治醫師
  • 林口長庚醫院內科部住院醫師
  • 林口長庚醫院胃腸肝膽科系住院醫師

學會與認證

  • 台灣內科醫學會專科醫師及指導醫師
  • 台灣消化系醫學會專科醫師及指導醫師
  • 台灣消化系內視鏡醫學會專科醫師
  • 中華民國醫用超音波學會專科醫師
  • 台灣醫學教育學會一般醫學師資
  • 美國癌症研究學會(American Association for Cancer Research) 會員

論文及期刊發表

  • Effectiveness and safety of 8-week glecaprevir/pibrentasvir in HCV treatment-naive patients with compensated cirrhosis: real-world experience from Taiwan nationwide HCV registry.
  • Above-standard survival of hepatocellular carcinoma as the final outcome of comprehensive hepatology care programs in a remote HCV-endemic area.
  • Niclosamide enhances sorafenib sensitivity through IGF-1R and metabolic changes in hepatocellular carcinoma.
  • Factors associated with large renal function decline in patients with chronic hepatitis C successfully treated with direct-acting antiviral therapy.
  • Direct-acting antivirals reduce the de novo development of esophageal varices in patients with hepatitis C related liver cirrhosis.
  • Changes in in renal function in chronic hepatitis C patients treated with sofosbuvir/velpatasvir.
  • Comparison of 8- versus 12-weeks of glecaprevir/pibrentasvir for Taiwanese patients with hepatitis C and compensated cirrhosis in a real-world setting.
  • Non-B, non-C hepatocellular carcinoma in an HBV- and HCV-endemic area: A community-based prospective longitudinal study.
  • Targeting galectin-1 inhibits hepatoma progression by inducing ADAM17-mediated TNFR1 shedding in carcinoma-associated fibroblasts.
  • The novel finding of dynamic change of eGFR to one year after end-of-treatment in HCV-infected patients receiving sofosbuvir and velpatasvir.
  • Factors associated with significant platelet count improvement in thrombocytopenic chronic hepatitis C patients receiving direct-acting antivirals.
  • Ledipasvir/sofosbuvir for HCV genotype 1, 2, 4-6 infection: Real-world evidence from a nationwide registry in Taiwan.
  • Community-based screening for hepatitis B and C virus activity using two quantitative antigens to identify endemic townships.
  • Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan.
  • Fusobacterium nucleatum infection is associated with decreased survival of Helicobacter pylori-positive gastric cancer patients.
  • A Yes-associated protein (YAP) and insulin-like growth factor 1 receptor (IGF-1R) signaling loop is involved in sorafenib resistance in hepatocellular carcinoma.
  • Village-to-village screening for hepatitis B and C using quantitative HBsAg and anti-HCV reflex HCV antigen tests in the remote communities of a resource-rich setting: a population-based prospective cohort study.
  • Real-world efficacy and safety of pangenotypic direct-acting antivirals against hepatitis C virus infection in Taiwan.
  • Pangenotypic direct-acting antiviral agents for mixed genotype hepatitis C infection: a real-world effectiveness analysis.
  • Sofosbuvir/velpatasvir is an effective treatment for patients with hepatitis C and advanced fibrosis or cirrhosis in a real-world setting in Taiwan.
  • The role of IGF/IGF-1R signaling in hepatocellular carcinomas: Stemness-related properties and drug resistance.
  • Immuno-metabolism: The role of cancer niche in immune checkpoint inhibitor resistance.
  • Epigenetic silencing of STAT3-targeted miR-193a, by constitutive activation of JAK/STAT signaling, leads to tumor progression through overexpression of YWHAZ in gastric cancer.
  • Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B.
  • Usefulness of quantitative hepatitis B surface antigen testing in hepatitis B community-based screening.
  • Challenges of transferring rural adults with chronic HCV infection for further HCVRNA confirmation and free DAAs treatment: a success story of interdisciplinary collaboration approach.
  • High viral load predicts virological failure in chronic genotype 2 hepatitis C virus-infected patients receiving glecaprevir/pibrentasvir therapy.
  • 2,4-diamino-quinazoline, a Wnt signaling inhibitor, suppresses gastric cancer progression and metastasis.
  • Real world effectiveness of glecaprevir/pibrentasvir and ledipasvir/sofosbuvir for mixed genotype hepatitis C infection: a multicenter pooled analysis in Taiwan.
  • Clinical utility of hepatitis C virus core antigen assay in the monitoring of direct-acting antivirals for chronic hepatitis C.
  • Liver health literacy and health status among adults with hepatitis C: implications for the nursing profession as part of the 2030 global elimination goal.
  • Limited effects of antibiotic prophylaxis in patients with Child–Pugh class A/B cirrhosis and upper gastrointestinal bleeding.
  • Incidence, risk factors and impact on virological response of anemia in chronic genotype 2 hepatitis C receiving sofosbuvir plus ribavirin.
  • DNMT3b/OCT4 expression confers poor prognosis and sorafenib sensitivity of hepatocellular carcinoma trough IL-6/STAT-3 regulation.
  • Esophageal perforation caused by a central venous catheter: a case report and literature review.
  • An investigation of the side effects, patient feedback, and physiological changes associated with direct-acting antiviral therapy for hepatitis C.
  • Prevalence and predictive value of high rheumatoid factor and anti-citrullinated protein antibody levels in nonarthritic patients with chronic hepatitis C infection.
  • Pretreatment inflammation-based markers predict survival outcomes in patients with early stage hepatocellular carcinoma after radiofrequency ablation.
  • The clinical roles of rheumatic factor in the treatment of chronic hepatitis C infection.
  • Inhibition of CCAR1, a coactivator of β-catenin, suppresses the proliferation and migration of gastric cancer cells
  • Transpapillary biliary biopsy for malignant biliary strictures: comparison between cholangiocarcinoma and pancreatic cancer.
  • Inflammation promotes expression of stemness-related properties in HBV-related hepatocellular carcinoma.
  • Hepatoprotective effect of esveratrol against ethanol-induced oxidative stress through induction of superoxide dimutase in vivo and in vitro.
  • Distribution of fatal Vibrio vulnificus necrotizing skin and soft-tissue infections: a systematic review and meta-analysis.
  • TGF-βI regulates cell migration through pluripotent transcription factor OCT4 in endometriosis.
  • Response to Braillon Hepatocellular carcinoma surveillance: A strategy that merits moving forward.
  • Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis.
  • Bupivacaine induces apoptosis through caspase-dependent and -independent pathways in canine mammary tumor cells.
  • Activation of IL6/IGF-IR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
  • Outcomes of endoscopic submucosal dissection for early gastric cancer and precancer lesion: Experience from a center in Southern Taiwan.
  • Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NFκB signaling pathway in gastric cancer cells.
  • Routine blood tests to predict liver fibrosis in chronic hepatitis C.
  • Serum HCV RNA level is not associated with the presence of insulin resistance and metabolic syndrome in chronic hepatitis C patients with genotype 1 or 2 infection.
  • Antibiotic strategy for pyogenic liver abscess: one medical center experience in Taiwan.
  • Paraesophageal hernia complicated with mediastinal abscess: Report of a case.
  • FibroQ: an easy and useful noninvasive test for predicting liver fibrosis in patients with chronic viral hepatitis.
  • Clinical features and outcome of chronic viral hepatitis with acute exacerbation in patients with concurrent infections of hepatitis B and C virus.
  • Endoscopic submucosal dissection for early gastric cancers: experience from a new endoscopic center in Taiwan.
  • Stapled hemorrhoidopexy for prolapsed hemorrhoids in patients with liver cirrhosis; a preliminary outcome for 8-case experience.
  • Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.
  • Successful treatment of pancreatic ascites by endoscopic pancreatic duct stenting: Report of a case.
  • Strangulated obturator hernia- a rare cause of small bowel obstruction: Report of a case.
  • Hepatitis C virus infection facilitates gallstone formation.
  • Application of lugol chromoendoscopy on the diagnosis of early esophageal cancer.
  • Gingival metastasis from gallbladder cancer, a case report.
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